AKIRA, Shizuo

Profile

Dr. Akira graduated Osaka University Medical School in 1977 and received his Ph.D. from the same institution in 1984. He spent the period from 1985 to 1987 as a Research Fellow in the Department of Microbiology and Immunology, California University. He returned to the Institute for Molecular and Cellular Biology in Osaka University, where he remained until 1996. After working in Hyogo College of Medicine for 3 years, he served as a Professor at RIMD from 1999 to 2018. Having concurrently served as the Director for WPI Immunology Frontier Research Center (IFReC), Osaka University from 2007 to 2019, he was appointed as SA Professor at IFReC and concurrently RIMD in 2018.

Publication

  • (1) Dysregulated expression of the nuclear exosome targeting complex component Rbm7 in nonhematopoietic cells licences the development of Fibrosis. Fukushima et al. Immunity. (2020) 52(3): 542-556.
  • (2) Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response. Tanaka et al. J. Exp. Med. (2019) 216(6): 1431-1449.
  • (3) Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism. Nagahama et al. Proc Natl Acad Sci U S A. (2018) 115(43): 11036-11041
  • (4) Identification of an atypical monocyte and committed progenitor involved in fibrosis. Satoh et al. Nature. (2017) 541(7635): 96-101
  • (5) Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation. Uehata et al. Cell. (2013) 153(5):1036-1049.
  • (6) Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Matsushita et al. Nature. (2009) 458(7242):1185-1190.

Lab

Aoshi, Taiki

Endowed Chair

Department of Cellular Immunology

Arase, Hisashi

Division of Host Defense

Department of Immunochemistry

Ebina, Hirotaka

BIKEN Innovative Vaccine Research Alliance Laboratories

Virus Vaccine Group

Hara, Eiji

Division of Cellular and Molecular Biology

Department of Molecular Microbiology

Horiguchi, Yasuhiko

Division of Infectious Disease

Department of Molecular Bacteriology

Horii, Toshihiro

Endowed Chair

Department of Malaria Vaccine Development

Iida, Tetsuya

Research Center for Infectious Disease Control

Department of Bacterial Infections

Ikawa, Masahito

Genome Information Research Center

Department of Experimental Genome Research

Ishitani, Tohru

Division of Cellular and Molecular Biology

Department of Homeostatic regulation

Iwanaga, Shiroh

Research Center for Infectious Disease Control

Department of Molecular Protozoology

Iwasaki, Masaharu

International Research Center for Infectious Diseases

Laboratory of Emerging Viral Diseases

Kinoshita, Taroh

Endowed Chair

Yabumoto Department of Intractable Disease Research

Kobayashi, Takeshi

Research Center for Infectious Disease Control

Department of Virology

Maeda, Yusuke

International Research Center for Infectious Diseases

Laboratory of Viral Dynamism Research

Matsuura, Yoshiharu

Research Center for Infectious Disease Control

Laboratory of Virus Control

Miki, Hiroaki

Division of Cellular and Molecular Biology

Department of Cellular Regulation

Mimuro, Hitomi

Division of Infectious Disease

Department of Infection Microbiology

Murakami, Yoshiko

Endowed Chair

Yabumoto Department of Intractable Disease Research

Nakamura, Shota

International Research Center for Infectious Diseases

Laboratory of Pathogen Detection and Identification

Okada, Masato

Division of Cellular and Molecular Biology

Department of Oncogene Research

Okamoto, Toru

Division of Infectious Disease

Institute for Advanced Co-Creation Studies

Shioda, Tatsuo

Division of Infectious Disease

Department of Viral Infections

Standley, Daron

Genome Information Research Center

Department of Genome Informatics

Suzuki, Kazuhiro

Division of Host Defense

Department of Immune Response Dynamics

Takakura, Nobuyuki

Division of Cellular and Molecular Biology

Department of Signal Transduction

Watanabe, Tokiko

Division of Infectious Disease

Department of Molecular Virology

Yamamoto, Masahiro

Division of Infectious Disease

Department of Immunoparasitology

Yamasaki, Sho

Division of Host Defense

Department of Molecular Immunology

Yoshioka, Yasuo

BIKEN Innovative Vaccine Research Alliance Laboratories

Vaccine Creation Group