Ishitani, Tohru

Profile

Prof. Ishitani received his Ph.D. from Nagoya University in 2002. After working as postdoctoral fellow in the same university, he became Associate Professor in the Medical Institute of Bioregulation, Kyushu University in 2006. He was appointed Professor in the Institute for Molecular and Cellular Regulation, Gunma University in 2017. He took his current position at RIMD in 2019.
He received Young Scientists' Prize of The Commendation for Science and Technology by MEXT in 2009, and Samuro Kakiuchi Memorial Award by the Japanese Biochemical Society in 2014, and NAGASE foundation award in 2020.

Publication

  • (1) Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB. Zou J, et al., Nature Commun. (2023) 14(1):7194.
  • (2) Zebrafish imaging reveals additional TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Haraoka Y., et al., Nature Commun. (2022) 13:1417
  • (3) Cell competition corrects noisy Wnt/β-catenin morphogen gradients to achieve robust patterning in the zebrafish embryo. Akieda Y., et al., Nature Commun. (2019)10: 4710
  • (4) Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Shimizu N., et al., Cell Reports (2014) 8(5) 1391-1404
  • (5) NLK positively regulates Wnt/β-catenin signalling by phosphorylating LEF1 in neural progenitor cells. Ota S., et al., EMBO Journal (2012) 31:1904-15
  • (6) Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Ishitani T., et al., Nat. Cell Biol. (2010) 12:278-85
  • (7) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Ishitani T., et al., Nat. Cell Biol. (2005) 7:1106-12
  • (8) The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Ishitani T., et al., Nature (1999) 399:798-802

Lab

Abe, Ryuichiro

International Research Center for Infectious Diseases

Laboratory of Bacterial Pathogenesis

Akira, Shizuo

Division of Host Defense

Department of Host Defense

Arase, Hisashi

Division of Host Defense

Department of Immunochemistry

Ebina, Hirotaka

BIKEN Innovative Vaccine Research Alliance Laboratories

Virus Vaccine Group

Hara, Eiji

Division of Cellular and Molecular Biology

Department of Molecular Microbiology

Horiguchi, Yasuhiko

Division of Infectious Disease

Department of Molecular Bacteriology

Horii, Toshihiro

Endowed Chair

Department of Malaria Vaccine Development

Iida, Tetsuya

Research Center for Infectious Disease Control

Department of Bacterial Infections

Ikawa, Masahito

Bioinformatics Center

Department of Experimental Genome Research

Iwanaga, Shiroh

Research Center for Infectious Disease Control

Department of Molecular Protozoology

Iwasaki, Masaharu

International Research Center for Infectious Diseases

Laboratory of Emerging Viral Diseases

Kinoshita, Taroh

Division of Host Defense

Laboratory of Immunoglycobiology

Kobayashi, Takeshi

Research Center for Infectious Disease Control

Department of Virology

Kotani, Ai

Division of Cellular and Molecular Biology

Laboratory of regulation of infectious cancer

Matsuura, Yoshiharu

Research Center for Infectious Disease Control

Laboratory of Virus Control

Murakami, Yoshiko

Division of Host Defense

Laboratory of Immunoglycobiology

Nakamura, Shota

Bioinformatics Center

Department of Infection Metagenomics

Shioda, Tatsuo

Division of Infectious Disease

Department of Viral Infections

Standley, Daron

Bioinformatics Center

Department of Genome Informatics

Suzuki, Kazuhiro

Division of Host Defense

Department of Immune Response Dynamics

Takakura, Nobuyuki

Division of Cellular and Molecular Biology

Department of Signal Transduction

Tsukamoto, Kentaro

International Research Center for Infectious Diseases

Laboratory of Bacterial Zoonoses

Watanabe, Tokiko

Division of Infectious Disease

Department of Molecular Virology

Yamamoto, Masahiro

Division of Infectious Disease

Department of Immunoparasitology

Yamasaki, Sho

Division of Host Defense

Department of Molecular Immunology

Yoshioka, Yasuo

BIKEN Innovative Vaccine Research Alliance Laboratories

Vaccine Creation Group