Yamasaki, Sho

Profile

Dr. Yamasaki received his Ph.D. from Kyoto University in 1999. After working at Mitsubishi Chemical Corporation and Chiba University Graduate School of Medicine, he worked for Research Center for Allergy and Immunology, RIKEN from 2004 to 2009. He was appointed as Professor in Medical Institute of Bioregulation, Kyushu University in 2009. He took his current position at RIMD from 2017.

Publication

(1)Invariant TCR-triggered Protein kinase D activation mediates NKT cell development. Ishikawa E.,et al. J. Exp.Med. (2025) 222:e20250541
(2)Identification of α-galactosylceramide as an endogenous mammalian antigen for iNKT cells. Hosono Y.,et al. J. Exp. Med. (2025) 222:e20240728
(3) A conserved human CD4+ T cell subset recognizing the mycobacterial adjuvant trehalose monomycolate. Sakai Y.,et al. J. Clin. Invest. (2024) 135:e185443, 2024
(4) The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells. Watanabe M., et al. Sci. Signal. (2023) 16:eabn9909
(5) Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease. Shimizu T., et al. Immunity. (2023) 56:307-19
(6) Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2. Haji S., et al. eLife. (2022) 11:e83037
(7) Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b. Shibata K, et al. Nat. Commun. (2022) 13:6948
(8) Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients. Lu X, et al. J. Exp. Med. (2021) 218:e20211327
(9) Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors. Nagata M., et al. J. Exp. Med. (2021) 218:e20200815
(10) Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR. Omahdi Z., et al J Biol Chem. (2020) 295(17):5807-5817
(11) Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection. Imai T., et al. Proc. Natl. Acad. Sci USA. (2018) 115:E10662-71
(12) Intracellular metabolite β－glucosylceramide is an endogenous Mincle ligand possessing immunostimulatory activity. Nagata M., et al. Proc. Natl. Acad. Sci. USA. (2017) 114:E3285-94
(13) Protein kinase D regulates positive selection of CD4(+) thymocytes through phosphorylation of SHP-1. Ishikawa E., et al. Nat. Commun. (2016) 7:12756
(14) C-type Iectin receptor DCAR recognizes mycobacterial phosphatidyl-inositol mannosides to promote a Th1 response during infection. Toyonaga K., et al. Immunity. (2016) 45:1245-57