幸谷愛

Profile

1996年京都大学医学部医学科卒業後、京都大学医学部附属病院、静岡市立病院にて内科研修を経て2003年医学博士（京都大学内山卓教授)。学術振興会特別研究員（京都大学本庶佑教授）、出産育児復帰支援特別研究員（Whitehead Institute for Biomedical Research Dr. Harvey Lodish）、東京大学医科学研究所先端医療研究センター・血液腫瘍内科助教（東條有伸教授）を経て2011年より東海大学創造科学研究機構医学部門テニュアトラック准教授(PI)、2016年東海大学医学部血液腫瘍内科学教授、2024年より微生物病研究所教授。

Publication

1. Kameda K., et al., Hepatic niche leads to aggressive NK-cell leukemia proliferation through transferrin-transferrin receptor 1 axis. BLOOD (2023) 142(4):352-364
2. Kudo K., et al., Secreted phospholipase A2 modifies extracellular vesicles and accelerates B cell lymphoma. Cell Metab, (2022) 34, 615-633.e8.
3. Yamamoto Y., et al., Anti-HBV drug entecavir ameliorates DSS-induced colitis through PD-L1 induction. Pharmacol Res (2022) 179, 105918.
4. Kakizaki M., et al., Human hepatocyte-derived extracellular vesicles attenuate the carbon tetrachloride-induced acute liver injury in mice. Cell Death and Disease (2021) 12, 1010.
5. Kakizaki M., et al., Extracellular vesicles secreted by HBV-infected cells modulate HBV persistence in hydrodynamic HBV transfection mouse model. J Biol Chem (2020) 295, 12449-12460.
6. Kawashima M., et al., PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma. Leukemia (2020) 24-Feb.
7. Higuchi H., et al., Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma. BLOOD (2018) 131, 2552-2567.
8. Yamakawa N., et al., Novel functional small RNAs are selectively loaded onto mammalian Ago1. Nucleic acids research (2014) 42(8), 5289-301.
9. Okuyama K., et al., MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors. PNAS (2013) 110(33) 13410-13415.
10. Kawamata T., et al., Imatinib mesylate directly impairs class switch recombination through down-regulation of AID: its potential efficacy as an AID suppressor. BLOOD (2012) 119(13), 3123-3127.

研究室紹介