小林剛

Profile

2000年大阪大学大学院医学研究科修了（医学博士）、同年微生物病研究所助手。2003年米国Vanderbilt大学博士研究員を経て2008年京都大学ウイルス研究所助教。2012年微生物病研究所感染症国際研究センターウイルス複製グループ特任准教授、2016年微生物病研究所ウイルス免疫分野准教授、2020年より現職。

Publication

(1) Recovery of infectious recombinant human norovirus using zebrafish embryos. Kotaki T., et al., PNAS. (2025)122:e2526726122.
(2) Single-round infectious rotaviruses with deletions of VP7 or VP4 genes, based on SA11 and WC3 strain backbones, and their potential use as viral vectors. Kotaki T., et al., PLoS Pathog. (2025)21:e1013484.
(3) A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection. Kotaki T., et al., mBio. (2025)16:e0089725.
(4) Establishment of reverse genetics systems for Colorado tick fever virus. Minami S., et al., PLoS Pathog. (2025)21:e1012921.
(5) The nonstructural p17 protein of a fusogenic bat-borne reovirus regulates viral replication in virus species- and host-specific manners. Nouda R., et al., PLoS Pathog. (2022)18:e1010553.
(6) Development of an entirely plasmid-based reverse genetics system for 12-segmented double-stranded RNA viruses. Nouda R., et al., PNAS. (2021)118:e2105334118.
(7) Cell-cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses. Kanai Y., et al., PLoS Pathog. (2019)15:e1007675.
(8) Entirely plasmid-based reverse genetics system for rotaviruses. Kanai Y., et al., PNAS. (2017)114:2349-2354.
(9) Reverse Genetics for Fusogenic Bat-Borne Orthoreovirus Associated with Acute Respiratory Tract Infections in Humans: Role of Outer Capsid Protein sigmaC in Viral Replication and Pathogenesis. Kawagishi T., et al., PLoS Pathog. (2016)12:e1005455.

研究室紹介