Research Activities
TCR-like antibodies regulate T cell responses (Arase Lab, in Nat Commun)
Antigen-specific regulation of T cell response is crucial for limiting hyperimmune response. Howe...
An in vivo fitness gene of Toxoplasma, MIC11, is essential for PLP1-mediated egress from host cells (Yamamoto Lab, in Nat Commun)
After invasion and replication, intracellular pathogens must egress from infected host cells.&nbs...
Reevaluation of the Efficacy of Senolytic Agents: The Importance of Reproducibility and Rigorous Evaluation (Hara Lab, in EMBO Reports)
A research group led by Professor Eiji Hara at the Research Institute for Microbial Diseases, The...
Fomite transmission of Mycobacterium abscessus between severely disabled patients (Nakaura Lab, in Clin. Microbiol. Infect.)
Yoshida and Nakamura et al. investigated a nosocomial outbreak of Mycobacterium abscessus subsp. ...
Comparison of Culture and Culture-free Methods for Comprehensive Identification of Mycobacteria: A Single-Center Prospective Study (Nakamura Lab, in J. Clin Microbiol.)
The genus Mycobacterium includes Mycobacterium tuberculosis as well as more than 200 species of n...
Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses (Watanabe Lab, iScience)
Influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are respirator...
Inflammatory mediators of mRNA vaccine-induced adverse reactions in mice (Yoshioka Lab, Mol Ther)
mRNA vaccines are promising vaccine modalities against infectious diseases. However, these vaccin...
miR-195 Enables EBF1-Independent B Cell Differentiation via FOXO1 Accumulation (Kotani Lab, in eLife)
Accumulated studies have reported that hematopoietic differentiation was primarily regulated by t...
Transcription Factor PbAP2-TR Is Essential for Malaria Parasite Development in Blood (Iwanaga Lab, Nat Commun)
Malaria is caused by the proliferation of Plasmodium parasites in the vertebrate host blood strea...
Overcoming Senolytic Drug Resistance in Senescent Cells through Mitochondrial Control (Hara Lab, in Nature Aging)
Summary
A research team led by Professor Eiji Hara and Assistant Professor Masahiro Wakita (RIMD...
Mycobacterial α-glucans hijack Dectin-1 to facilitate intracellular bacterial survival (Yamasaki Lab, in Science Immunology)
Mycobacteria have a cell envelope that can act as a shield against host defense. This study shows...
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