Research Activities
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses (Yoshioka Lab, in JCI)
Intranasal vaccines are anticipated to be powerful tools for combating many infectious diseases, ...
Zebrafish dorsal organizer size is determined by a Wnt-Tlr4/NFκB negative feedback loop (Ishitani Lab, in Nat Commun)
In vertebrate embryos, the canonical Wnt ligand primes the formation of dorsal organizers that go...
A novel toxin, inactivating heterotrimeric Gi GTPases, from Bordetella parapertussis (Horiguchi Lab, in PNAS)
Researchers (Dr. Yukihiro Hiramatsu and Prof. Yasuhiko Horiguchi) from Dept. of Molecular Bacteri...
The importance of polyploidy in predicting the prognosis of liver cancer (Hara Lab, in Br. J. Cancer)
Hepatocellular carcinoma (HCC) is the most common type of human liver cancer. Although genome dup...
Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice (Takakura Lab, in Angiogenesis)
Tissue-resident vascular endothelial stem cells (VESCs), marked by expression of CD157, possess l...
A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity (Yamamoto_Lab, Cell Reports)
Regulatory T (Treg) cells expressing the transcription factor (TF) Foxp3 also express other TFs s...
The double face of RNase as a treatment for systemic autoimmune diseases (Arase Lab, JCI INsight)
Systemic autoimmune diseases are characterized by inflammation of multiple organs and can have de...
Discovery of the mechanism by which the leprosy bacillus disrupts macrophages (Yamasaki Lab, in ACS Central Science)
Although leprosy (Hansen’s disease) is one of the oldest known diseases, the pathogenicity ...
Host genetics uncover IFN-γ-dependent Toxoplasma genes in in vivo CRISPR screens (Yamamoto Lab, in Cell Reports)
While the presence of harmful critters in your home may be addressed by a call to the exterminato...
Age-related B-cell senescence causes dysbiosis of gut microbiota. (Hara Lab, in Nat. Cell. Biol.)
【Summary】
A research group led by Professor Eiji Hara (concurrently with Immunology Frontier Res...
A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility (Ikawa Lab, in Nat. Commun)
The mammalian spermatozoa produced in the testis require functional maturation in the epididymis ...
The mechanism by which Bordetella bronchiseptica avoids predation by amoebae. (Horiguchi Lab, in Microbiol. Spectr.)
Research led by postdoctoral fellow Dendi Krisna Nugraha and Prof. Yasuhiko Horiguchi of the Depa...
A herbal compound to fight autoimmunity (Suzuki Lab, in Science Immunology)
Researchers in Suzuki Lab identified a protein complex involved in the pathogenesis of rheum...
MGIT-seq for the Identification of Nontuberculous Mycobacteria and Drug Resistance: a Prospective Study (Nakamura Lab, in J. Clin. Microbiol.)
Because nontuberculous mycobacterial pulmonary disease is a considerable health burden, a simple ...
Genomic diversity of SARS-CoV-2 can be accelerated by mutations in the nsp14 gene (Watanabe Lab, iScience)
Coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), encode a p...
Key protein for streamlined sperm may pave the way for contraceptives for men (Ikawa Lab, in PNAS)
Researchers from Ikawa Lab identified the role of a protein in the elimination of sperm cytoplasm...
Timing matters for dendritic cell signaling (Yamasaki Lab, in Sci. Signal.)
Dendritic cells detect pathogens through pattern recognition receptors, which generate distinct c...
Elucidating the Regulatory Mechanisms for the Biosynthesis of Glycosylphosphatidylinositol (Kinoshita Lab, in J. Cell Biol.)
A research group led by Professor Taroh Kinoshita of the Research Institute for Microbial Disease...
1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm–egg interaction (Ikawa Lab, in PNAS)
A study led by Assistant Professor Yonggang Lu and Professor Masahito Ikawa in the Department of ...
Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease（Yamasaki Lab, Immunity)
Gaucher disease (GD) is the most common lysosomal storage disease caused by recessive mutations i...
Toxoplasma IWS1 determines fitness in interferon-γ-activated host cells and mice by indirectly regulating ROP18 mRNA expression (Yamamoto Lab, in mBio)
Toxoplasma gondii secretes various virulence effector molecules into host cells to disrupt h...
Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility (Ikawa Lab, in Science Advances)
Researchers in Ikawa-Lab (Department of Experimental Genome Research) have identified a prot...
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