Research Activities

New Pathogenic Mechanism of Systemic Lupus Erythematosus (Arase Lab, in Arthritis and Rheumatology)

A research group led by Professor Hisashi Arase of the Research Institute for Microbial Diseases,...

More

Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients (Yamasaki Lab, in JEM)

Adaptive immunity is a fundamental component in controlling COVID-19. In this process, follicular...

More

Development of an entirely plasmid-based reverse genetics system for 12-segmented double-stranded RNA viruses (Kobayashi Lab, in PNAS)

The family Reoviridae is non-enveloped virus group with a double-stranded (ds) RNA genome compris...

More

Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion (Hara Lab, in Nat Commun)

Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal ...

More

Mouse sperm need a molecular VIP pass to reach the egg membrane (Ikawa Lab, in PNAS)

Fertilisation is one of the most fundamental biological processes, yet its underlying molecular m...

More

RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization (Ikawa Lab, in Journal of Cell Biology)

Zygotes require two accurate sets of parental chromosomes, one each from the mother and the fathe...

More

Discovery of a molecule that regulates sperm motility (Ikawa lab, in PNAS)

Researchers from Osaka University found that sperm protein SPATA33 regulates sperm motility, whic...

More

Engineered ACE2 receptor therapy overcomes mutational escape of SARS-CoV-2 (Okamoto Lab in Nat. Commun.)

SARS-CoV-2 has mutated during the global pandemic leading to viral adaptation to medications and ...

More

Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure (from Miki-Lab, in Nat. Commun.)

Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the...

More

How hepatitis C virus evades the immune system (From Okamoto Lab, in PNAS)

Hepatitis C virus (HCV) may cause chronic infection to the liver, which can result in irreversibl...

More

Antibodies that enhance the SARS-CoV-2 infection (Arase Lab, in Cell)

A research group led by Professor Hisashi Arase at Osaka University find that infection with SARS...

More

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells (Yamamoto Lab, JEM)

Because of their common signaling molecules, the main T cell receptor (TCR) signaling cascades in...

More

A novel, quick, and easy system for genetic analysis of SARS-CoV-2 (Matsuura Lab, in Cell Reports)

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. We know that mutations in the geno...

More

The role of Gal-3 in maintaining the quiescent state of hematopoietic stem cells (Takakura Lab, in Nat Commun)

The research group in the Department of Signal Transduction, researcher Weizhen Jia and professor...

More

A bacterial small RNA regulates the adaptation of H. pylori to the host environment (Mimuro Lab, in Nat Commun)

Long-term infection of the stomach with Helicobacter pylori can cause gastric cancer. However, th...

More

CDCP1 promotes compensatory renal growth by integrating Src and Met signaling (Okada-Lab, in Life Science Alliance)

Controlling organ size during development and/or regenerative growth is important for maintaining...

More

Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter (Miki Lab, in Science Advances)

The CNNM/CorC family proteins are Mg2+ transporters that are widely distributed in all domains of...

More

ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility (Ikawa Lab, PNAS)

The mammalian sperm midpiece has a unique double helical structure called the mitochondrial sheat...

More