Ishitani, Tohru

Profile

Dr. Ishitani received his Ph.D. from Nagoya University in 2002. After working as postdoctoral fellow in the same university, he became Associate Professor in the Medical Institute of Bioregulation, Kyushu University in 2006. He was appointed Professor in the Institute for Molecular and Cellular Regulation, Gunma University in 2017. He took his current position at RIMD in 2019.
He received Young Scientists' Prize of The Commendation for Science and Technology by MEXT in 2009, and Samuro Kakiuchi Memorial Award by the Japanese Biochemical Society in 2014, and NAGASE foundation award in 2020.

Publication

(1) Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development. Matsumoto K and Akieda Y., et al., Nature Commun. (2024) 15:10662
(2) Mechano-gradients drive morphogen-noise correction to ensure robust patterning. Aoki K et al., Science Advances (2024) 10:eadp2357.
(3) Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Abe K et al., Science Advances (2024) 10:eadi1621
(4) Determining zebrafish dorsal organizer size by a negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB. Zou J, et al., Nature Commun. (2023) 14(1):7194.
(5) Zebrafish imaging reveals additional TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis. Haraoka Y., et al., Nature Commun. (2022) 13:1417
(6) Cell competition corrects noisy Wnt/β-catenin morphogen gradients to achieve robust patterning in the zebrafish embryo. Akieda Y., et al., Nature Commun. (2019)10: 4710
(7) Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. Ishitani T., et al., Nat. Cell Biol. (2010) 12:278-85
(8) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Ishitani T., et al., Nat. Cell Biol. (2005) 7:1106-12
(9) The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Ishitani T., et al., Nature (1999) 399:798-802

Lab