2014年以前の代表論文（37報を抜粋）。

Nagano K, Maeda Y, Kanasaki S, Watanabe T, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. JControlled Release. 189: 72-9, 2014.

Yoshida T, Yoshioka Y（コレスポンディングオーサー）, Tochigi S, Hirai T, Uji M, Ichihashi K, Nagano K, Abe Y, Kamada H, Tsunoda S, Nabeshi H, Higashisaka K, Yoshikawa T, Tsutsumi Y. Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice. Part Fibre Toxicol. 10: 41, 2013.

Yoshikawa M, Mukai Y, Okada Y, Tsumori Y, Tsunoda S, Tsutsumi Y, Aird WC, Yoshioka Y, Okada N, Doi T, Nakagawa S. Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody. Blood. 121: 2804-13, 2013.

Yao X, Yoshioka Y, Ruan G, Chen Y, Mizuguchi H, Mukai Y, Okada N, Gao JQ, Nakagawa S. Optimization and internalization mechanisms of PEGylated adenovirus vector with targeting peptide for cancer gene therapy. Biomacromolecules. 13: 2402-9, 2012.

Morishige T, Yoshioka Y（コレスポンディングオーサー）, Inakura H, Tanabe A, Narimatsu S, Yao X, Monobe Y, Imazawa T, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. Suppression of nanosilica particle–induced inflammation by surface modification of the particles. Arch Toxicol. 86: 1297-307, 2012.

Hirai T, Yoshikawa T, Nabeshi H, Yoshida T, Tochigi S, Ichihashi K, Uji M, Akase T, Nagano K, Abe Y, Kamada H, Itoh N, Tsunoda S, Yoshioka Y, Tsutsumi Y. Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection. Part Fibre Toxicol. 9: 3, 2012.

Yamashita K, Yoshioka Y（コレスポンディングオーサー）, Higashisaka K, Mimura K, Morishita Y, Nozaki M, Yoshida T, Ogura T, Nabeshi H, Nagano K, Abe Y, Kamada H, Monobe Y, Imazawa T, Aoshima H, Shishido K, Kawai Y, Mayumi T, Tsunoda S, Itoh N, Yoshikawa T, Yanagihara I, Saito S, Tsutsumi Y. Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. Nat Nanotechnol. 6: 321-8, 2011.

Higashisaka K, Yoshioka Y（コレスポンディングオーサー）, Yamashita K, Morishita Y, Fujimura M, Nabeshi H, Nagano K, Abe Y, Kamada H, Tsunoda S, Yoshikawa T, Itoh N, Tsutsumi Y. Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials. Biomaterials. 32: 3-9, 2011.

Yao X, Yoshioka Y（コレスポンディングオーサー）, Morishige T, Eto Y, Narimatsu S, Kawai Y, Mizuguchi H, Gao JQ, Mukai Y, Okada N, Nakagawa S. Tumor vascular targeted delivery of polymer-conjugated adenovirus vector for cancer gene therapy. Mol Ther. 19: 1619-25, 2011.

Mukai Y, Yoshinaga T, Yoshikawa M, Matsuo K, Yoshikawa T, Matsuo K, Niki K, Yoshioka Y, Okada N, Nakagawa N. Induction of endoplasmic reticulum-endosome fusion for antigen cross-presentation induced by poly (γ-glutamic acid) nanoparticles. J Immunol. 187: 6249-55, 2011.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Itoh N, Tsunoda S, Tsutsumi Y. Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes. Part Fibre Toxicol. 8: 1, 2011.

Nomura T, Abe Y, Kamada H, Shibata H, Kayamuro H, Inoue M, Kawara T, Arita S, Furuya T, Yamashita T, Nagano K, Yoshikawa T, Yoshioka Y, Mukai Y, Nakagawa S, Taniai M, Ohta T, Serada S, Naka T, Tsunoda S, Tsutsumi Y. Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice. J Control Release. 149: 8-14, 2011.

Imai S, Nagano K, Yoshida Y, Okamura T, Yamashita T, Abe Y, Yoshikawa T, Yoshioka Y, Kamada H, Mukai Y, Nakagawa S, Tsutsumi Y, Tsunoda SI. Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins. Biomaterials. 32: 162-169, 2011.

Abe Y, Yoshikawa T, Inoue M, Nomura T, Furuya T, Yamashita T, Nagano K, Nabeshi H, Yoshioka Y, Mukai Y, Nakagawa S, Kamada H, Tsutsumi Y, Tsunoda S. Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning. Biomaterials. 32: 5498-504, 2011.

Nabeshi H, Yoshikawa T, Matsuyama K, Nakazato Y, Matsuo K, Arimori A, Isobe M, Tochigi S, Kondoh S, Hirai T, Akase T, Yamashita T, Yamashita K, Yoshida T, Nagano K, Abe Y, Yoshioka Y, Kamada H, Imazawa T, Nakagawa S, Mayumi T, Itoh N, Tsunoda S, Tsutsumi Y. Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application. Biomaterials. 32: 2713-24, 2011.

Yoshioka Y（コレスポンディングオーサー）, Watanabe H, Morishige T, Yao X, Ikemizu S, Nagao C, Ahmad S, Mizuguchi K, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. Creation of lysine-deficient mutant lymphotoxin- with receptor selectivity by using a phage display system. Biomaterials. 31: 1935-43, 2010.

Morishige T, Yoshioka Y（コレスポンディングオーサー）, Inakura H, Tanabe A, Yao X, Narimatsu S, Monobe Y, Imazawa T, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1b production, ROS production and endosomal rupture. Biomaterials. 31: 6833-6842, 2010.

Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J Virol. 84: 12703-12, 2010.

Morishige T, Yoshioka Y（コレスポンディングオーサー）, Inakura H, Tanabe A, Yao X, Tsunoda S, Tsutsumi Y, Mukai Y, Okada N, Nakagawa S. Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy. Biomaterials. 31: 3357-63, 2010.

Yoshida T, Yoshioka Y（コレスポンディングオーサー）, Fujimura M, Yamashita K, Higashisaka K, Nakanishi R, Morishita Y, Kayamuro H, Nabeshi H, Nagano K, Abe Y, Kamada H, Tsunoda S, Yoshikawa T, Itoh N, Tsutsumi Y. Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation. Toxicol Lett. 199: 383-8, 2010.

Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y. Solution of the Structure of the TNF-TNFR2 Complex. Sci Signal. 3: ra83, 2010.

Kojima H, Mukai Y, Yoshikawa M, Kamei K, Yoshikawa T, Morita M, Inubushi T, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S. Simple PEG conjugation of SPIO via an Au-S bond improves its tumor targeting potency as a novel MR tumor imaging agent. Bioconjug Chem. 21: 1026-31, 2010.

Kamei K, Mukai Y, Kojima H, Yoshikawa T, Yoshikawa M, Kiyohara G, Yamamoto TA, Yoshioka Y, Okada N, Seino S, Nakagawa S. Direct cell-entry of gold/iron-oxide magnetic nanoparticles in adenovirus mediated gene delivery. Biomaterials. 30: 1809-14, 2009.

Yao X, Yoshioka Y（コレスポンディングオーサー）, Morishige T, Eto Y, Watanabe H, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S. Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis. Gene Ther. 16: 1395-404, 2009.

Shibata H, Yoshioka Y, Abe Y, Ohkawa A, Nomura T, Minowa K, Mukai Y, Nakagawa S, Taniai M, Ohta T, Tsunoda S, Kamada H, Tsutsumi Y. The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF. Biomaterials. 30: 6638-47, 2009.

Kayamuro H, Abe Y, Yoshioka Y, Katayama K, Nomura T, Yoshida T, Yamashita K, Yoshikawa T, Kawai Y, Mayumi T, Hiroi T, Itoh N, Nagano K, Kamada H, Tsunoda S, Tsutsumi Y. The use of a mutant TNF-a as a vaccine adjuvant for the induction of mucosal immune responses. Biomaterials. 30: 5869-76, 2009.

Ohgiya Y, Arakawa F, Akiyama H, Yoshioka Y, Hayashi H, Sakai S, Ito S, Yamakawa Y, Ohgiya S, Ikezawa Z, Teshima R. Molecular cloning, expression and characterization of a major 38 kDa cochineal allergen. J Allergy Clin Immunol. 123: 1157-62, 2009.

Shibata H, Yoshioka Y, Ohkawa A, Minowa K, Mukai Y, Abe Y, Taniai M, Nomura T, Kayamuro H, Nabeshi H, Sugita T, Imai S, Nagano K, Yoshikawa T, Fujita T, Nakagawa S, Yamamoto A, Ohta T, Hayakawa T, Mayumi T, Vandenabeele P, Aggarwal BB, Nakamura T, Yamagata Y, Tsunoda S, Kamada H, Tsutsumi Y. Creation and X-ray structure analysis of the tumor necrosis factor receptor-1 selective mutant of a TNF alpha antagonist. J Biol Chem. 283: 998-1007, 2008.

Hayashi A, Wakita H, Yoshikawa T, Nakanishi T, Tsutsumi Y, Mayumi T, Mukai Y, Yoshioka Y, Okada N, Nakagawa S. A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity. J Control Release. 117: 11-9, 2007.

Gao JQ, Eto Y, Yoshioka Y, Sekiguchi F, Kurachi S, Morishige T, Yao X, Watanabe H, Asavatanabodee R, Sakurai F, Mizuguchi H, Okada Y, Mukai Y, Tsutsumi Y, Mayumi T, Okada N, Nakagawa S. Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration. J Control Release. 122: 102-10, 2007.

Sakai S, Akiyama H, Sato Y, Yoshioka Y, Robert J. Linhardt, Goda Y, Maitani T, Toida T. Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice. J Biol Chem. 281: 19872-80, 2006.

Shibata H, Yoshioka Y, Ikemizu S, Kobayashi K, Yamamoto Y, Mukai Y, Okamoto T, Taniai M, Kawamura M, Abe Y, Nakagawa S, Hayakawa T, Nagata S, Yamagata Y, Mayumi T, Kamada H, Tsutsumi Y. Functionalization of tumor necrosis factor-alpha using phage display technique and PEGylation improves its antitumor therapeutic window. Clin Cancer Res. 10: 8293-300, 2004.

Kodaira H, Tsutsumi Y, Yoshioka Y, Kamada H, Kaneda Y, Yamamoto Y, Tsunoda SI, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. The targeting of anionized polyvinylpyrrolidone to the renal system. Biomaterials. 25: 4309-15, 2004.

Kamada H, Tsutsumi Y, Yoshioka Y, Yamamoto Y, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy. Clin Cancer Res. 10: 2545-50, 2004.

Kaneda Y, Tsutsumi Y, Yoshioka Y, Kamada H, Yamamoto Y, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S, Mayumi T. The use of PVP as a polymeric carrier to improve the plasma half-life of drugs. Biomaterials. 25: 3259-66, 2004.

Yamamoto Y, Tsutsumi Y, Yoshioka Y, Nishibata T, Kobayashi K, Okamoto T, Mukai Y, Shimizu T, Nakagawa S, Nagata S, Mayumi T. Site-specific PEGylation of a lysine-deficient TNF-alpha with full bioactivity. Nat Biotechnol. 21: 546-52, 2003.

Kamada H, Tsutsumi Y, Sato-Kamada K, Yamamoto Y, Yoshioka Y, Okamoto T, Nakagawa S, Nagata S, Mayumi T. Synthesis of a poly(vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting. Nat Biotechnol. 21: 399-404, 2003.

特許
吉岡靖雄、穐山　浩、庄司俊彦、神田智正、松田りえ子、米谷民雄
「炎症性腸疾患予防剤」　
特許5167461号（登録日：平成25年1月11日）

角田慎一、堤　康央、吉岡靖雄
「粘膜ワクチン用アジュバント」
特許5539660号（登録日：平成26年5月9日）

特許出願中
堤　康央、吉岡靖雄、東阪和馬、増野匤彦、大江知之、山名修一、青島央江
「潰瘍性大腸炎の予防または治療剤と新規フラーレン誘導体」
特願2013-030455、PCT/JP2014/53950