Research Activities

Genome-wide functional screening of drug-resistance genes in Plasmodium falciparum. (Iwanaga Lab, in Nat. Commun.)

Prof. Iwanaga group developed the method for identifying drug resistance gene using Plasmodium ar...

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Deadly piston pump: how a colonization factor is secreted by bacterial type 4 pili (Nakamura Lab, in Sci. Adv.)

Bacterial infectious diseases are still a huge contributor to global disease burden and with anti...

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Human sperm TMEM95 binds eggs and facilitates membrane fusion (Ikawa Lab, in PNAS)

A research led by Assistant Professor Yonggang Lu and Professor Masahito Ikawa in the Department ...

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Rapid reverse genetics systems for Nothobranchius furzeri, a suitable model organism to study vertebrate aging (Ishitani Lab, in Scientific Reports)

The African turquoise killifish Nothobranchius furzeri (N. furzeri) is a useful mo...

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Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition (Okada Lab, in Current Biology)

Abnormal/cancerous cells within healthy epithelial tissues undergo apical extrusion to protect ag...

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The nonstructural p17 protein of a fusogenic bat-borne reovirus regulates viral replication in virus species- and host-specific manners (Kobayashi Lab, in PLOS PATHOGENS)

Nelson Bay orthoreovirus (NBV), a member of the family Reoviridae, genus Orthoreovirus, is a bat-...

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Secretory glycoprotein NS1 plays a crucial role in the particle formation of flaviviruses (Matsuura-Lab, in PLOS Pathogens)

Flaviviruses, which are globally distributed and cause a spectrum of potentially severe illnesses...

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Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy(Kinoshita Lab, Nat. Commun.)

Inherited glycosylphosphatidylinositol (GPI) deficiency (IGD) is caused by mutations in GPI biosy...

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Ethanolamine-phosphate on the second mannose is a preferential bridge for some GPI-anchored proteins. (Kinoshita Lab, EMBO Rep.)

Glycosylphosphatidylinositols (GPIs) are glycolipids that anchor many proteins (GPI-APs) on the c...

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Decoy receptor protects against Omicron infection(Okamoto Lab & Daron Lab, in Sci. Trans. Med)

Researchers from Japan find that an engineered version of the SARS-CoV-2 receptor, angiotensin-co...

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Coughing mice and the fight against pertussis (Horiguchi Lab, in mBio)

Researchers from Osaka University uncover the specific molecular mechanism behind how the whoopin...

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Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis (Kinoshita Lab, in PNAS)

Glycosylphosphatidylinositols (GPIs) are complex glycolipids that act as membrane anchors of many...

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Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis (Ishitani Lab, in Nat. Commun.)

Most tumours are thought to arise through oncogenic cell generation followed by additional mutati...

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Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules (Arase Lab, in Science Advances)

Gravesʼ disease is an autoimmune disease in which autoantibodies against thyroid-stimulating horm...

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SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response (Hara Lab, in Nat Aging )

Reports of "post-acute COVID-19 syndrome," in which the inflammatory response persists ...

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