Research Activities
Keep quiet or be eliminated: how cell competition modulates morphogen gradients (from Ishitani-lab, in Nat. Commun.)
Tissue patterning is an important process during embryo formation, as well in adult tissue, which...
Male mice, caged in the International Space Station for 35 days, sire healthy offspring (from Ikawa-Lab, in Sci. Rep.)
The space environment (e.g., radiation, gravity change) influence our health during space stay. D...
Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation. (Kinoshita Lab, in JCI)
Here, we report the mechanistic basis of atypical paroxysmal nocturnal hemoglobinuria (PNH) cause...
Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice (Ikawa Lab in PNAS)
CRISPR/Cas9-mediated genome editing technology enables re- searchers to efficiently generate and ...
Comprehensive subspecies identification of nontuberculous mycobacteria species (Nakamura Lab, in Emerging Microbes & Infections)
The prevalence of nontuberculous mycobacteria (NTM) pulmonary diseases has been increasing worldw...
Mutations in PIGB cause an inherited GPI biosynthesis defect (Kinoshita Lab, in AJHG)
Proteins anchored to the cell surface via glycosylphosphatidylinositol (GPI) play various key rol...
CXCR4 regulates Plasmodium development in mouse and human hepatocytes (Yamamoto Lab, in JEM)
The liver stage of the etiological agent of malaria, Plasmodium, is obligatory for successful inf...
Cell–cell fusion induced by reovirus FAST proteins enhances replication and pathogenicity of non-enveloped dsRNA viruses (Kobayahi-Lab, in Plos Pathogens)
Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces c...
Key Amino Acid Substitution for Infection- Enhancing Activity-Free Designer Dengue Vaccines (MOCID, in iScience)
Dengue is a globally important disease caused by four serotypes of dengue virus. Dengue vaccine d...
Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis (Takakura_Lab, in Nat Commun)
The balance between self-renewal and differentiation of hematopoietic stem and progenitor cells (...
Vibrio parahaemolyticus injects an exotoxin into host cells to evoke diarrhea (from Iida lab, in Nat Microbiol)
Vibrio parahaemolyticus is a Gram-negative marine bacterium that causes acute, seafood-associated...
TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity (Takakura Lab, in Dev. Cell)
TNFα is a pleiotropic cytokine which has potential to induce apoptosis under inflammat...
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