Research Activities
Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors (Yamasaki Lab, in JEM)
Helicobacter pylori (H.pylori) causes gastritis, which has been attributed to the developmen...
The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis(from Miki Lab, in Dev. Cell)
Extracellular pH is usually maintained around 7.4 in multicellular organisms, and cells are optim...
Various miRNAs compensate the role of miR-122 on HCV replication (from Matsuura Lab, in PLOS Pathog.)
A liver-specific microRNA, miR-122, is one of the key determinants of hepatitis C virus (HCV) hep...
Discovery of a molecule that is essential for the formation of sperm flagella (Ikawa Lab, in AJHG)
Groups including Department of Experimental Genome Research discovered a molecule that is essenti...
Novel switch protein that ‘turns on’ sperm for fertilization (Ikawa-Lab, in Science)
Researchers from Osaka University and Baylor College of Medicine identify a protein secreted by t...
Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice (Ikawa Lab, in PNAS)
Sperm-oocyte membrane fusion is one of the most important events for fertilization. So far, IZUMO...
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells (Hara Lab, in Nat Commun)
Although cellular senescence acts primarily as a tumour suppression mechanism, the accumulation o...
Discovery of sperm membrane protein FIMP involved in membrane fusion during fertilization (Ikawa Lab, in PNAS)
ABSTRACT
Sperm-oocyte fusion is a critical event in mammalian fertilization, categorized by thre...
Development of a new-generation Lassa virus live-attenuated vaccine candidate (Iwasaki Lab in mBio)
Several arenaviruses cause viral hemorrhagic fever in humans and pose important public health pro...
Bordetella dermonecrotic toxin is a neurotropic virulence factor that uses CaV3.1 as the cell surface receptor (from Horiguchi lab, in mBio)
Abstract:
Dermonecrotic toxin (DNT) is one of the representative toxins produced by Bordete...
Isolation of tissue-resident vascular endothelial stem cells from mouse liver (Takakura Lab, in Nat. Protocols)
Endothelial cells (ECs) are fundamental components of the blood vessels that comprise the vascula...
Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation (Kinoshita Lab, in Nat. Commun.)
Glycosylphosphatidylinositol (GPI) is a glycolipid for post-translational modification of many ce...
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