発表論文

*Corresponding author
Okumura, S., Konishi, Y., Narukawa, M., Sugiura, Y., Yoshimoto, S., Arai, Y., Sato, S., Yoshida, Y., Tsuji, S., Uemura, U., Wakita, M., Matsudaira, T., Matsumoto, T., Kawamoto, S., Takahashi, A., Itatani, Y., Miki, H., Takamatsu, M., Obama, K., Takeuchi, K., Suematsu, M., Ohtani, N., Fukunaga, Y., Ueno, M., Sakai, Y., *Nagayama, S. & *Hara, E.
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.
Nature Commun., 12: 5674 doi: 10.1038/s41467-021-25965-x (2021).
Featured in Nature Communications' Editors' Highlights (Cancer).
Miyata, K., Imai, Y., Hori, S., Nishio, M., Loo, T.-M., Okada, R., yang, L., nakadai, T., maruyama, R., Fujii, R., Ueda, K., Jiang, L., Zheng, H., Toyokuni, S., Shirahige, K., Kojima, R., nakayama, M., Oshima, M., Nagayama, S., Seimiya, H., Saya, H., Hara, E. & *Takahashi, A.
Pericentromeric noncoding RNA changes DNA binding of CTCF and inflammatory gene expression in senescence and cancer.
Proc. Natl. Acad. Sci. USA, doi: 10.1073/pnas.2025647118.(2021).
Wakita, M., Takahashi, A., Sano, O., Loo, T. M., Imai, Y., Narukawa, M., Iwata, H., Matsudaira, T., Kawamoto, S., Ohtani, N., Yoshimori, T. & *Hara, E.
A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells.
Nature Commun., 11:1935 doi: 10.1038/s41467-020-15719-6 (2020).
Tadokoro,Y., Hoshii,T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshimam M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & *Hirao, A.
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell Stem Cell., 22:713-725(2018).
Takahashi, A., Loo, T. M., Okada, R., Kamachi, F., Watanabe, Y., Wakita, M., Watanabe, S., Kawamoto, S., Miyata, K., Barber, G. N., Ohtani, N. & *Hara, E.
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Nature Commun., 9: 1249 doi: 10.1038/s41467-081-03555-8 (2018).
*Okuma, A., Hanyu, A., Watanabe, S., & *Hara, E.
p16INK4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.
Nature Commun., 8: 2050 doi: 10.1038/s41467-017-02281-x (2017).
*Takasugi, M., Okada, R., Takahashi, A., Chen, D.V., Watanabe, S., & *Hara, E.
Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
Nature Commun., 8: 15728 doi: 10.1038/ncomms15728 (2017).
*Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M.T., Obuse, C. & *Hara, E.
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.
Nature Commun., 8: 15287 doi: 10.1038/ncomms15287 (2017).
Loo, T.M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., Ozawa, T., Nakamura, M., Kumagai, M., Watashi, K., Taketo, M.M., Aoki, T., Narumiya, S., Oshima, M., Arita, M., Hara, E. & *Ohtani, N.
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Cancer Discov., doi: 10.1158/2159-8290.CD-16-0932. [Epub ahead of print] (2017)
Sato, S., Kawamata, Y., Takahashi, A., Imai, Y.,Hanyu, A., Okuma, A., Takasugi, M., Yamakoshi, K., Sorimachi, H., Kanda, H., Ishikawa, Y., Sone, S., Nishioka, Y., *Ohtani, N. & *Hara, E.
Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice.
Nature Commun., 6: 7035 doi: 10.1038/ncomms8035 (2015).
Demaria, M., Ohtani, N., Youssef, S.A., Rodier, F., Toussaint, W., Mitchell, J.R., Laberge, R.M., Vijg, J., van Steeg, H., Dolle, M.E.T., Hoeijmakers, J.H.J., de Bruin, A., Hara, E. & *Campisi, J.
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
Dev. Cell, 31: 722-733 (2014)
Johmura, Y., Shimada, M., Misaki, T., Naiki-Ito, A., Miyoshi, H., Motoyama, N., Ohtani, N., Hara, E., Nakamura, M., Morita, A., Takahashi, S. & *Nakanishi M.
Necessary and sufficient role for a mitosis skip in senescence induction.
Mol Cell, 55: 73-84 (2014) 
Imai, Y., Takahashi, A., Hanyu, A., Hori, S., Sato, S., Naka, K., Hirao, A., Ohtani, N. & *Hara, E.
Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch.
Cell Rep., 7: 194-207 (2014) 
Yoshimoto, S., Loo, T.M., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., *Hara, E. & Ohtani, N.
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.
Nature., 499: 97-101(2013) 
(Selected for News & Views)
This work was featured in Science's 'Breakthrough of the Year 2013'
Takahashi, A., Imai, Y., Yamakoshi, K., Kuninaka, S., Ohtani, N., Yoshimoto, S., Hori, S., Tachibana, M., Anderton, E., Takeuchi, T., Shinkai, Y., Peters, G., Saya, H. & *Hara, E.
DNA damage signaling triggers degradation of histone methyltransferases through APC/CCdh1 in senescent cells.
Mol. Cell, 45: 123-131(2012) 
Yamakoshi, K., Takahashi, A., Hirota, F., Nakayama, R., Ishimaru, N., Kubo, Y., Mann, D.J., Ohmura, M., Hirao, A., Saya, H., Arase, S., Hayashi, Y., Nakao, K., Matsumoto, M., *Ohtani, N. & *Hara, E.
Real-time in vivo imaging of p16INK4a reveals cross-talk with p53.
J. Cell Biol., 186: 393-407 (2009)
Inomata, K., Aoto, T., Binh, N.T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H. & *Nishimura, E.K.
Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation.
Cell, 137: 1088-1099 (2009)
*Ohtani, N., Imamura, Y., Yamakoshi, K., Hirota, F., Nakayama, R., Kubo, Y., Ishimaru, N., Takahashi, A., Hirao, A., Shimizu, T., Mann, D.J., Saya, H., Hayashi, Y., Arase, S., Matsumoto, M., Nakao, K. & *Hara, E.
Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals
Proc. Natl. Acad. Sci. USA, 104: 15034-15039 (2007)
Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S., Tahara, H.,Nakayama, K., Nakayama, K.I., Ide, T., Saya, H. & *Hara, E.
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
Nature Cell Biol., 8: 1291-1297 (2006)
(Selected for News & Views)
*Laman, H., Funes, J., Ye, H., Henderson, S., Galinanes-Garcia, L., Hara, E., Knowles, P., McDonald, N. & Boshoff, C.
Transforming activity of Fbxo7 is mediated specifically through regulation of cyclinD/cdk6.
EMBO J., 24: 3104-3116 (2005)
Maehara, K., Yamakoshi, K., Ohtani, N., Kubo, Y., Takahashi, A., Arase, S., Jones, N. & *Hara, E.
Reduction of total E2F/DP activity induces senescence-like cell cycle arrest in cancer cells lacking functional pRB and p53.
J. Cell Biol., 167: 553-560 (2005)
Ohtani, N., Brennan, P., Gaubatz, S., Sanij, E., Hertzong, P., Wolvetang, E., Ghysdael, J., Rowe, M. & *Hara, E.
Epstein-Barr virus LMP1 blocks p16INK4a-RB-pathway by promoting nuclear export of E2F4/5.
J. Cell Biol., 162: 173-183 (2003)
(Selected for Cover page)
Ohtani, N., Zebedee, Z., Huot, T.J.G., Stinson, J.A., Sugimoto, M., Ohashi, Y., Sharrrocks, A.D., Peters, G. & *Hara, E.
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.
Nature, 409: 1067-1070 (2001).
Sugimoto, M., Nakamura, T., Ohtani, N., Hampson, L., Hampson, I.N., Shimamoto, A., Furuichi, Y., Okumura, K., Niwa, S., Taya Y. & *Hara, E.
Regulation of CDK4 activity by a novel CDK4 binding protein, p34SEI-1.
Genes & Dev., 13: 3027-3033 (1999).
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