Infertility research by Professor Masahito Ikawa et al. was published in Science.

Professor Ikawa, Assistant Professor Miyata, and colleagues found that the enzyme that is composed of PPP3CC and PPP3R2 (sperm calcineurin) is necessary for proper sperm motility and mice lacking sperm calcineurin are sterile. Further, normal mice treated for 2 weeks with calcineurin inhibitors became infertile owing to the same motility defects. Because fertility recovered a week after halting drug administration, specific inhibition of sperm calcineurin may lead to the development of reversible male contraceptives that work in a short span of time. This study was electronically published in Science on Oct. 1st 2015, and was reported by Daily Mail (UK), Los Angeles Times (USA), Newsweek (USA), Asahi Shinbun, and Nikkei Shinbun etc.