IL-17-mediated phosphorylation of Regnase-1 (Akira G in JEM)

Hiroki Tanaka, Shizuo Akira (Host Defense, IFReC/RIMD, Osaka University), and their research group demonstrated that interleukin 17 induces phosphorylation of Regnase-1 in an Act1-TBK1/IKKi-dependent manner, especially in nonhematopoietic cells.

This article was published in The Journal of Experimental Medicine on May 14, 2019.

Title：Phosphorylation-dependent Regnase-1 release from endoplasmic reticulum is critical in IL-17 response.

Authors： Hiroki Tanaka, Yasunobu Arima, Daisuke Kamimura, Yuki Tanaka, Noriyuki Takahashi, Takuya Uehata, Kazuhiko Maeda, Takashi Satoh¹, Masaaki Murakami. Shizuo Akira.

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Akira Lab (IFReC, Host Defense)

This article in The Journal of Experimental Medicine website