5/16(Wed)Using cutting-edge genomics technologies to decode host-microbe interactions
May 9, 2018
Events and Seminars
A Seminar by Dr. Rays H.Y. Jian from University of South Florida will be held on May 16, 2018.
| Date | Wednesday, May 16, 2018 10:00am- |
| Venue |
Biken Hall (1F RIMD Main building) |
| Title | Using cutting-edge genomics technologies to decode host-microbe interactions |
| Speaker |
Dr. Rays H.Y. Jian (Global Health, University of South Florida, Tampa, FL, USA) |
| Abstract | Microbes are able to manipulate complex host tissues with a diverse array of strategies, such as obligate pathogens colonizing living host tissues, parasites transforming host cells, and gut microbiomes interacting with enteric tissues of vertebrates and invertebrates. To understand the molecular underpinning of these microbe-host interactions, we are using an interdisciplinary approach combining bioengineering and cutting-edge genomics to unravel the mechanisms of microbe nutrient acquisitions, niche establishments and host immune suppressions. We are currently using bioengineering to create an in vitro human liver system capable of sustaining hundreds of primary hepatocyte functions to study human liver infections like liver stage malaria (Roth et al, Nature Communications, 2018 in press). We have also developed massively parallel random mutagenesis methods for the human malaria parasite to map the essential genome (Zhang et al, Science 2018, PMID:29724925). Finally, we are implementing and developing single cell omics technologies, with microfluidic engineering and advanced genomics computation, to understand host-microbe interactions at single cell resolutions. |
This Seminar will be conducted in English.
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