学歴

1996　東京大学農学部農芸化学科卒業
2003　東京大学大学院医学系研究科修了、博士（医学）

職歴

1998 - 1999　三共株式会社
2003 - 2005　科学技術振興事業団・研究員
2005 - 2007　東京大学医科学研究所・助手
2007 - 2011　神戸大学大学院医学研究科・助教
2011 - 2017　大阪大学微生物病研究所・助教
2017 - 現在　大阪大学微生物病研究所・准教授

研究業績

1. Funato, Y., Yamazaki, D., Okuzaki, D., Yamamoto, N., and Miki, H.
   Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
   Nat. Commun. 12, 3683 (2021)


2. #Yamazaki, D., Hashizume, O., Taniguchi, S., Funato, Y., and #Miki, H. (#: co-correspondence)
   Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture.
   Sci. Rep. 11, 3980 (2021)


3. Funato, Y., Yoshida, A., Hirata, Y., Hashizume, O., Yamazaki, D., and Miki, H.
   The oncogenic PRL protein causes acid addiction of cells by stimulating lysosomal exocytosis.
   Dev. Cell 55, 387-397 (2020)


4. Ito, S., Nada, S., Yamazaki, D., Kimura, T., Kajiwara, K., Miki, H., and Okada, M.
   p18/Lamtor1-mTORC1 signaling controls development of mucin-producing goblet cells in the intestinal epithelium.
   Cell Struct. Funct. 45, 93-105 (2020)


5. Hashizume, O., Funato, Y., Yamazaki, D., and Miki, H.
   Excessive Mg²⁺ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species.
   Antioxid. Redox Signal. 33, 20-34 (2020)


6. Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H.N., Mori, M.X., Mori, Y., Sato, T., and Miki, H.
   Cnnm4 deficiency suppresses Ca²⁺ signaling and promotes cell proliferation in the colon epithelia.
   Oncogene 38, 3962-3969 (2019)


7. Funato, Y., Yamazaki, D., and Miki, H.
   Renal function of cyclin M2 Mg²⁺ transporter maintains blood pressure.
   J. Hypertens. 35, 585-592 (2017)


8. Ishii, T., Funato, Y., Hashizume, O., Yamazaki, D., Hirata, Y., Nishiwaki, K., Kono, N., Arai, H., and Miki, H.
   Mg²⁺ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
   PLoS Genet. 12, e1006276 (2016)


9. Yamazaki, D., Funato, Y., Miyata, H., Ikawa, M., and Miki, H.
   Complementary role of CNNM2 in sperm motility and Ca(2+) influx during capacitation.
   Biochem. Biophys. Res. Commun. 474, 441-446 (2016)


10. Yamazaki, D., Miyata, H., Funato, Y., Fujihara, Y., Ikawa, M., and Miki, H.
    Mg²⁺ transporter CNNM4 regulates sperm Ca²⁺ homeostasis and is essential for reproduction.
    J. Cell Sci. 129, 1940-1949 (2016)


11. Funato, Y., Yamazaki, D., Mizukami, S., Du, L., Kikuchi, K., and Miki, H.
    Membrane protein CNNM4-dependent Mg²⁺ efflux suppresses tumor progression.
    J. Clin. Invest. 124, 5398-5410 (2014)


12. Yamazaki, D., Funato, Y., Miura, J., Sato, S., Toyosawa, S., Furutani, K., Kurachi, Y., Omori, Y., Furukawa, T., Tsuda, T., Kuwabata, S., Mizukami, S., Kikuchi, K., and Miki, H.
    Basolateral Mg²⁺ Extrusion via CNNM4 Mediates Transcellular Mg²⁺ Transport across Epithelia: A Mouse Model.
    PLoS Genet. 9, e1003983 (2013)


13. Yamazaki, D., Itoh, T., Miki, H., and Takenawa, T.
    srGAP1 regulates lamellipodial dynamics and cell migratory behavior by modulating Rac1 activity.
    Mol. Biol. Cell 24, 3393–3405 (2013)


14. Yamazaki, D., Kurisu S., and Takenawa T.
    Involvement of Rac and Rho signaling in cancer　cell motility in 3D substrates.
    Oncogene 28, 1570-1583 (2009)


15. Eto, K., Nishikii, H., Ogaeri, T., Suetsugu, S., Kamiya, A., Kobayashi, T., Yamazaki, D., Oda, A., Takenawa, T., and Nakauchi, H.
    The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implication for platelet biogenesis and spreading machinery.
    Blood 110, 3637-3647 (2007)


16. Nakanishi, O., Suetsugu, S., Yamazaki, D., and Takenawa, T.
    Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex.
    J. Biochem. (Tokyo) 141, 319-325 (2007)


17. #Yamazaki H., #Yamazaki, D., Takaya, N., and Takagi, M., Ohta, A., and Horiuchi, H. (#: equal contribution)
    A chitinase gene, chiB, involved in the autolytic process of Aspergillus nidulans.
    Curr. Genet. 51, 89-98 (2007)


18. Yamazaki, D., Oikawa T., and Takenawa, T.
    Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.
    J. Cell Sci. 120, 86-100 (2007)


19. Suetsugu, S., Kurisu, S., Oilkawa T., Yamazaki, D., Oda, A., and Takenawa, T.
    Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.
    J. Cell Biol. 173, 571-585 (2006)


20. Yamazaki, D., Kurisu, S., and Takenawa, T.
    Regulation of cancer cell motility through actin reorganization.
    Cancer Sci. 96, 379-386 (2005)


21. Yamazaki, D., Fujiwara, T., Suetsugu, S., and Takenawa, T.
    A novel function of WAVE1 in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading.
    Genes. Cells 10, 381-392 (2005)


22. Kurisu, S., Suetsugu, S., Yamazaki, D., Yamaguchi, H., and Takenawa, T.
    Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.
    Oncogene 24, 1309-1319 (2005)


23. Kawamura, K., Takano, K., Suetsugu, S., Kurisu, S., Yamazaki, D., Miki, H., Takenawa, T., and Endo, T.
    N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor
    J. Biol. Chem. 279, 54862-54871 (2004)


24. Oda, A., Miki, H., Wada, I., Yamaguchi, H., Yamazaki, D., Suetsugu, S., Nakajima, M., Nakayama, A., Okawa, K., Miyazaki, H., Matsuno, K., Ochs, H. D., Machesky, L. M., Fujita, H., and Takenawa, T.
    WAVE/Scars in Platelets.
    Blood 105, 3141-3148(2005)


25. Oikawa, T., Yamaguchi, H., Itoh, T., Kato, M., Ijuin, T., Yamazaki, D., Suetsugu, S., and Takenawa, T.
    PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia.
    Nat. Cell Biol. 6, 420-426(2004)


26. Suetsugu, S., Yamazaki, D., Kurisu, S., and Takenawa, T.
    Differential roles of WAVE1 and WAVE2 in dorsal and peripheral ruffle formation for fibroblast cell migration.
    Dev. Cell 5, 595-609 (2003)


27. Yamazaki, D., Suetsugu, S., Miki, H., Kataoka, Y., Nishikawa, S., Fujiwara, T., Yoshida, N., and Takenawa,
    WAVE2 is required for directed cell migration and cardiovascular development.
    Nature 424, 452-456 (2003)


28. Takaya, N., Yamazaki, D., Horiuchi, H., Ohta, A., and Takagi, M.
    Intracellular chitinase gene from Rhizopus oligosporus: molecular cloning and characterization.
    Microbiology 144, 2647-2654 (1998)


29. Takaya, N., Yamazaki, D., Horiuchi, H., Ohta, A., and Takagi, M.
    Cloning and characterization of a chitinase-encoding gene (chiA) from Aspergillus nidulans, disruption of which decreases germination frequency and hyphal growth.
    Biosci. Biotechnol. Biochem. 62, 60-65 (1998)