/Animal Resource Center for Infectious Diseases  About Animal Resource Center

  To study infectious diseases and cancer, it is important to analyze interactions between pathogenic factors and the human body. Animal models are indispensable for biomedical research, particularly since molecular biology and biotechnology methods can be used to generate genetically modified mice that aid our understanding of the molecular mechanisms underlying such diseases. Experimentally infected animals and genetically engineered animals used for these purposes should be managed in a suitable, safe, and controlled manner. The Animal Resource Center for Infectious Diseases is a unique facility that was established in 1967 to meet these requirements.   The center is equipped with pass-through-type autoclave systems and HEPA filtered air exchange systems to minimize the risk of contamination so that infected or genetically engineered animals are maintained in a safe environment. The animals are housed in three areas: SPF (specific pathogen free), BSL (biosafety level) 2, and BSL3. Before gaining access to restricted areas, researchers must take an official orientation and submit a research plan for committee review. The condition of the animals is monitored regularly.   Our facility provides the following services: generation of genetically manipulated animals, in vitro fertilization, and cryopreservation of mouse strains(Table1). The facility provides these services in co-operation with the Department of Experimental Genome Research.

 

  IVF/ET TG KO, KI

2000まで

261 228 50
2001-2003 443 104 57
2004-2006 331 43 69
2007-2009 216 22 74
2010-2012 388 55 152
2013-2015 580 50 242
2016-2018 505 21 191

Table1 Tg, Transgenic; KO, Knockout; IVF, in vitro Fertilization; ET, Embryo transfer.

※Includes lines generated using the CRISPR/Cas9 genome editing system.

  • Buildings at the Animal Resource Center.
    Building A (in front of the chimney, built in 1967, two-story).
    Building B (rear right of the chimney, built in 1978, four-story).
    Building C (on the right side of Building A, built in 2009, four-story).

  • Biosafety level 3 room.
    The room is used for research involving disease model animals at biosafety level 3. Hemorrhagic fever with renal syndrome-causing virus (HFRSV) was isolated in this area. In addition, animal experiments involving Zika virus, SARS, and Acquired Immune Deficiency Syndrome (AIDS), can be handled in this facility.

Staff

  • Head, Professor: Masahito Ikawa
  • Asst. Prof.: Keisuke Shimada
  • Assoc. Prof. (concur.): Haruhiko Miyata
  • Assoc. Prof.: Norikazu Yabuta
  • Asst. Prof. (concur.): Taichi Noda
  • SA Asst. Prof. (concur.): Daiji Kiyozumi
  • SA Asst. Prof. (concur.): Tsutomu Endo

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