/Animal Resource Center for Infectious Diseases  About Animal Resource Center

 To study infectious diseases, immunological responses, and cancer, it is important to analyze interactions between pathogenic factors and the human body. Animal models are indispensable for biomedical research, particularly since molecular biology and biotechnology methods can be used to generate genetically modified mice that aid our understanding of the molecular mechanisms underlying such diseases. Experimentally infected animals and genetically engineered animals used for these purposes should be managed in a suitable, safe, and controlled manner. The Animal Resource Center for Infectious Diseases is a unique facility that was established in 1967 to meet these requirements.


 The center is equipped with pass-through-type autoclave systems and HEPA filtered air exchange systems to minimize the risk of contamination so that infected or genetically engineered animals are maintained in a safe environment. The animals are housed in two areas: SPF (specific pathogen free) and BSL2 (biosafety level 2). The condition of the animals is monitored regularly. Before gaining access to restricted areas, researchers must take an official orientation and all the animal experiments have to be approved by the Institutional Animal Care and Use Committee. We follow the 3Rs (Replacement ,Reduction, Refinement) and the five freedoms for animals.


 Our facility provides the following services: generation of genetically manipulated animals, in vitro fertilization, and cryopreservation of mouse strains (Table 1 ). The facility provides these services in co-operation with the Department of Experimental Genome Research. For more information about our research and services, please visit our homepage (https://arcid.biken.osaka-u.ac.jp/).




261 228 50
2001-2003 443 104 57
2004-2006 331 43 69
2007-2009 216 22 74
2010-2012 388 55 152
2013-2015 580 50 242
2016-2018 505 21 191

Table1 Tg, Transgenic; KO, Knockout; IVF, in vitro Fertilization; ET, Embryo transfer.

※Includes lines generated using the CRISPR/Cas9 genome editing system.

  • Buildings at the Animal Resource Center.
    Building A (left, built in 2019, four-story).
    Building C (right, built in 2009, four-story).

  • Biosafety level 3 room.
    The room is used for research involving disease model animals at biosafety level 3. Hemorrhagic fever with renal syndrome-causing virus (HFRSV) was isolated in this area. In addition, animal experiments involving Zika virus, SARS, and Acquired Immune Deficiency Syndrome (AIDS), can be handled in this facility.


  • Head, Professor: Masahito Ikawa(concur.)
  • Assoc. Prof.: Haruhiko Miyata(concur.)
  • Assoc. Prof.: Norikazu Yabuta
  • Asst. Prof.: Keisuke Shimada
  • Asst. Prof.: Chihiro Emori(concur.)
  • SA Asst. Prof.: Yuki Hiradate(concur.)