Shioda Lab/Research Collaboration Center for Infectious Diseases  Section of Antiviral Research

Recently, climate change and urbanization have increased the risk of vector-borne diseases. Dengue and chikungunya viruses cause dengue fever/hemorrhagic fever and chikungunya fever, respectively. Both viruses are transmitted by Aedes mosquitoes. In 2014, there was an outbreak of dengue fever in Tokyo. However, no antiviral drugs are available to treat these infections. Our aim is to develop antiviral drugs against dengue and chikungunya viruses.

 

Four serotypes of dengue virus are distributed across the world, and re-infection with different serotypes of dengue virus leads to a more severe infection. We aim to develop novel diagnostic tools that can differentiate between the four serotypes of dengue virus.

  • Figure: Structure of RNA-dependent RNA polymerase (blue) and
    its inhibitor RK-0404678 (red)

Staff

  • Prof.(concur.): Tatsuo Shioda

Website

Publications

  • 1. Discovery of a small molecule inhibitor ta1ge1ing dengue virus NS5 RNA·dependent ANA polymerase. Shim ~u H et al., PLoS Negl Trop Dis. (2019)13(11):
    2. Evaluation of novel rapid detection kits for dengue virus NS1 antigen in Dhaka, Bangladesh, in 2017 Su1uki K. et al. Virol J. (2019) Aug 15: 16(1):102 doi: 10.1186/s12985-019-1204-y.
    3. Broad-spectrum monoclonal antibodies against chikungunya virus structural proteins· promising candidates for antibody-based rapid diagnostic test development. Tuekprakhon A. et al, PLoS One. (2018) 13(12).
    4. Evaluation of an immunochromatography rapid diagnosis kit for detection of chikungunya virus antigen in India. a dengue·endemic country. Jain J et al., Virol J.(2018)15(1):84
    5. Variation at position 350 in the Chikungunya virus 6K-E1 protein determines the sensitivity of detection in a rapid E1-antigen test. Tuekprakhon A. et al, Sci Rep. (2018)8(1) :1094
    6. Diagnostic accuracy of a rapid E1-antigen test for chikungunya virus infection in a reference setting. Huits R et al., Clin Microbial lnfect.(2018)24 (1):78-81