Shioda Lab／Research Collaboration Center for Infectious Diseases Section of Antiviral Research
Recently, climate change and urbanization have increased the risk of vector-borne diseases. Dengue and chikungunya viruses cause dengue fever/hemorrhagic fever and chikungunya fever, respectively. Both viruses are transmitted by Aedes mosquitoes. In 2014, there was an outbreak of dengue fever in Tokyo. However, no antiviral drugs are available to treat these infections. Our aim is to develop antiviral drugs against dengue and chikungunya viruses.
Four serotypes of dengue virus are distributed across the world, and re-infection with different serotypes of dengue virus leads to a more severe infection. We aim to develop novel diagnostic tools that can differentiate between the four serotypes of dengue virus.
- Prof.(concur.): Tatsuo Shioda
- SA Asst. Prof.(concur.): Akatsuki Saito
- (1) Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. Saito A., J Virol. (2016) 11;90(15):6918-35.
(2) Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74. Saito A., J Virol. (2016) 27;90(12):5808-23
(3) Sequence diversity of dengue virus type 2 in brain and thymus of infected interferon receptor ko mice: implications for dengue virulence. Dhole P., et al., Virol J. (2016) 13(1):199.