Research Activities
Mechano-Gradients Ensure Precision in Biological Patterns (Ishitani Lab, in Science Advances)
Morphogen gradients instruct cells to pattern tissues. Although the mechanisms by which morphogen...
Platelet factor 4-induced Th1-Treg polarization suppresses anti-tumor immunity (Yamamoto Lab, in Science)
Major points
The chemokine PF4 secreted by Arg1-producing tumor-associated macrophages (Arg1+ ...
IFN-γ-induced Th1-Treg polarization in inflamed brains limits exacerbation of experimental autoimmune encephalomyelitis (Yamamoto Lab, in PNAS)
Experimental autoimmune encephalomyelitis (EAE) is the most widely used rodent model for multiple...
Neoself-antigens induce autoimmunity in lupus (Arase Lab, in Cell)
Major points
It has long been a mystery why immune cells attack their own tissues in autoimmun...
CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma (Yamamoto Lab, in mBio)
The research field to identify and characterize genes essential for in vivo virulence i...
Extracellular amino acid influx via LAT1 regulates cellular sensitivity to a transferrin-receptor 1 inhibitory antibody (PPMX-T003) of aggressive natural killer cell leukemia (Kotani Lab, in Leukemia)
Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy associated with...
Lipid Nanoparticle with 1,2-Di-O-octadecenyl-3-trimethylammonium-propane as a Component Lipid Confers Potent Responses of Th1 Cells and Antibody against Vaccine Antigen (Yoshioka Lab,in ACS Nano)
Adjuvants are effective tools to enhance vaccine efficacy and control the type of immune response...
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells (Ishitani Lab,in Science Advances)
Women live longer than men. This isn’t unique to humans, either; we see this trend in a wid...
Pulling Out the Stops: Deletion of Regnase-1 promotes anti-tumor activity in NK cells (Akira Lab,in Immunity)
Natural killer (NK) cells play a crucial role in the first line of host defense by eliminating ba...
Aging disrupts the spatial regulation of regenerative signaling.(Ishitani Lab,in NPJ Aging )
Wnt/β-catenin signaling plays a major role in regulation of embryogenesis, organogenesis, an...
Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages. (Yamamoto Lab, in Nat. Commun.)
Toxoplasma gondii is a global protozoan pathogen. Clonal lineages predominate in Europe, Nor...
Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies (Yamasaki Lab, eLife)
SARS-CoV-2 vaccines have been used worldwide to combat COVID-19 pandemic. To elucidate the factor...
A transcriptional regulatory circuit amplifies virulence gene expression in Vibrio parahaemolyticus (Iida-Lab, PLOS Pathogens)
RIMD researchers elucidate an autoregulatory circuit of a virulence regulator gene expression in ...
Identification of an endogenous antigen for MAIT cells (Yamasaki Lab, Sci. Immun.)
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize bacterial ribo...
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