研究業績

2018年

  • Hiradate Y, Sasaki E, Momose H, Asanuma H, Furuhata K, Takai M, Aoshi T, Yamada H, Ishii KJ, Tanemura K, Mizukami T, Hamaguchi I. Development of screening method for intranasal influenza vaccine and adjuvant safety in preclinical study. Biologicals. 2018 Jul 13. pii: S1045-1056(18)30213-6. doi: 10.1016/j.biologicals.2018.07.001. [Epub ahead of print] PMID: 30017557
  • Takahashi H, Misato K, Aoshi T, Yamamoto Y, Kubota Y, Wu X, Kuroda E, Ishii KJ, Yamamoto H, Yoshioka Y. Carbonate Apatite Nanoparticles Act as Potent Vaccine Adjuvant Delivery Vehicles by Enhancing Cytokine Production Induced by Encapsulated Cytosine-Phosphate-Guanine Oligodeoxynucleotides. Front Immunol. 2018 Apr 18;9:783. doi: 10.3389/fimmu.2018.00783. eCollection 2018. PMID: 29720976


2017年

  • Wijaya E, Igarashi Y, Nakatsu N, Haseda Y, Billaud J, Chen YA, Mizuguchi K, Yamada H, Ishii K, Aoshi T. Quantifying the relative immune cell activation from whole tissue/organ-derived differentially expressed gene data. Sci Rep. 2017 Oct 9;7(1):12847. doi: 10.1038/s41598-017-12970-8. PMID: 28993694 Free PMC Article
  • Urakami A, Sakurai A, Ishikawa M, Yap ML, Flores-Garcia Y, Haseda Y, Aoshi T, Zavala FP, Rossmann MG, Kuno S, Ueno R, Akahata W. Development of a novel virus-like particle vaccine platform that mimics immature form of alphavirus.　Clin Vaccine Immunol. 2017 May 17. pii: CVI.00090-17. doi: 10.1128/CVI.00090-17. [Epub ahead of print] PMID: 28515133 Free Article
  • Aoshi T. Modes of Action for Mucosal Vaccine Adjuvants. Viral Immunol. 2017 Apr 24. doi: 10.1089/vim.2017.0026. [Epub ahead of print] PMID: 28436755
  • Hayashi M, Aoshi T, Haseda Y, Kobiyama K, Wijaya E, Nakatsu N, Igarashi Y, Standley DM, Yamada H, Honda-Okubo Y, Hara H, Saito T, Takai T, Coban C, Petrovsky N, Ishii KJ. Advax, a Delta Inulin Microparticle, Potentiates In-built Adjuvant Property of Co-administered Vaccines. EBioMedicine. 2017 Feb;15:127-136. doi: 10.1016/j.ebiom.2016.11.015. PMID: 27919753 Free PMC Article
  • Sasaki E, Kuramitsu M, Momose H, Kobiyama K, Aoshi T, Yamada H, Ishii KJ, Mizukami T, Hamaguchi I. A novel vaccinological evaluation of intranasal vaccine and adjuvant safety for preclinical tests. Vaccine. 2017 Feb 1;35(5):821-830. doi: 10.1016/j.vaccine.2016.12.036. PMID: 28063707

2016年
  • Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ. Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation. Immunity. 2016 Dec 20;45(6):1299-1310. doi: 10.1016/j.immuni.2016.11.010. PMID: 28002730
  • Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ. Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells. Oncotarget. 2016 Jul 1. doi: 10.18632/oncotarget.10379. [Epub ahead of print] PMID: 27384490
  • Hayashi M, Aoshi T, Ozasa K, Kusakabe T, Momota M, Haseda Y, Kobari S, Kuroda E, Kobiyama K, Coban C, Ishii KJ. RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine. Sci Rep. 2016 Jul 4;6:29165. doi: 10.1038/srep29165. PMID: 27374884
  • Shiraishi K, Kawano K, Maitani Y, Aoshi T, Ishii KJ, Sanada Y, Mochizuki S, Sakurai K, Yokoyama M. Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance. J Control Release. 2016 Jul 28;234:59-67. doi: 10.1016/j.jconrel.2016.05.010. Epub 2016 May 6. PMID: 27164541
  • Kohyama M, Matsuoka S, Shida K, Sugihara F, Aoshi T, Kishida K, Ishii KJ, Arase H. Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα. Eur J Immunol. 2016 May;46(5):1214-23. doi: 10.1002/eji.201545897. Epub 2016 Feb 22. PMID: 26840635
  • Kobiyama K, Temizoz B, Kanuma T, Ozasa K, Momota M, Yamamoto T, Aoshi T, Kuroda E, Ishii KJ. Species-dependent role of type I IFNs and IL-12 in the CTL response induced by humanized CpG complexed with β-glucan. Eur J Immunol. 2016 May;46(5):1142-51. doi: 10.1002/eji.201546059. Epub 2016 Feb 9. PMID: 26786557


2015年
  • Hayashi M, Aoshi T, Kogai Y, Nomi D, Haseda Y, Kuroda E, Kobiyama K, Ishii KJ. Optimization of physiological properties of hydroxyapatite as a vaccine adjuvant. Vaccine. 2016 Jan 12;34(3):306-12. doi: 10.1016/j.vaccine.2015.11.059. Epub 2015 Dec 5. PMID: 26667613
  • Mochizuki S, Morishita H, Kobiyama K, Aoshi T, Ishii KJ, Sakurai K. Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs. J Control Release. 2015 Dec 28;220(Pt A):495-502. doi: 10.1016/j.jconrel.2015.11.008. Epub 2015 Nov 10.PMID: 26562685
  • Aoshi T, Haseda Y, Kobiyama K, Narita H, Sato H, Nankai H, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Kuroda E, Coban C, and K. Ishii. Development of non-aggregating poly-A tailed immunostimulatory A/D-type CpG oligodeoxynucleotides applicable for clinical use. Journal of Immunology Research. Volume 2015 (2015), Article ID 316364, http://dx.doi.org/10.1155/2015/316364.
  • Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN.　Eur J Immunol. 2015 Apr;45(4):1159-69. doi: 10.1002/eji.201445132. Epub 2015 Feb 5
  • Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley DM, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ. Hydroxypropyl-β-Cyclodextrin Spikes Local Inflammation That Induces Th2 Cell and T Follicular Helper Cell Responses to the Coadministered Antigen. J Immunol. 2015 Mar 15;194(6):2673-82. doi: 10.4049/jimmunol.1402027. Epub 2015 Feb 13. PMID: 25681338
  • Koo CX, Kobiyama K, Shen YJ, LeBert N, Ahmad S, Khatoo M, Aoshi T, Gasser S, Ishii KJ.RNA Polymerase III Regulates Cytosolic RNA:DNA Hybrids and Intracellular MicroRNA Expression. J Biol Chem. 2015 Mar 20;290(12):7463-73. doi: 10.1074/jbc.M115.636365. Epub 2015 Jan 26. PMID: 25623070
  • 特許関連
  • 非凝集性免疫賦活化オリゴヌクレオチド。石井健、青枝大貴、佐藤秀昭。特願2015-118731。
  •  

 

2014年

Yagi M, Bang G, Tougan T, Palacpac NM, Arisue N, Aoshi T, Matsumoto Y, Ishii KJ, Egwang TG, Druilhe P, Horii T. Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences. PLoS One. 2014 Jun 2; 9(6):e98460. doi: 10.1371/journal.pone.0098460. eCollection 2014.

Zhao H, Aoshi T, Kawai S, Mori Y, Konishi A, Ozkan M, Fujita Y, Haseda Y, Shimizu M, Kohyama M, Kobiyama K, Eto K, Nabekura J, Horii T, Ishino T, Yuda M, Hemmi H, Kaisho T, Akira S, Kinoshita M, Tohyama K, Yoshioka Y, Ishii KJ, Coban C. Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. Cell Host Microbe. 2014 May 14; 15(5):551-63. doi: 10.1016/j.chom.2014.04.008.

Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun. 2014 Mar 18; 5:3492. doi: 10.1038/ncomms4492.

Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii KJ. Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):3086-91. doi: 10.1073/pnas.1319268111.

青枝大貴, 石井健. 次世代ワクチンの方向性(解説) : 感染・炎症・免疫 44巻3号 Page194-207(2014.10)

小笹 浩二, 青枝 大貴, 石井 健. 予防接種とは　ワクチンにおける宿主免疫反応と副反応について(解説/特集)：感染症内科(2187-803X)2巻3号 Page225-234(2014.03)

特許関連

免疫賦活活性を有する核酸多糖複合体の抗腫瘍薬としての応用。石井健、青枝大貴、小檜山康司。PCT/JP2014/084772．

脳マラリアの診断および治療。ジェヴァイア　チョバン、吉岡芳親、石井健、青枝大貴。特許出願2014-66193.

2013年

Tang CK, Aoshi T, Jounai N, Ito J, Ohata K, Kobiyama K, Dessailly BH, Kuroda E, Akira S, Mizuguchi K, Coban C, Ishii KJ. The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant. PLoS One. 2013; 8(3):e60038. doi: 10.1371/journal.pone.0060038.

Shiraishi K, Hamano M, Ma H, Kawano K, Maitani Y, Aoshi T, Ishii KJ, Yokoyama M. Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon. J Control Release. 2013 Feb 10; 165(3):183-90. doi: 10.1016/j.jconrel.2012.11.016.

Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T. TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models. Hum Vaccin Immunother. 2013 Feb; 9(2):283-90.

青枝 大貴, 石井 健. ワクチンアジュバント　パンデミックにいかに備えるか(解説/特集) : 実験医学(0288-5514)31巻19号 Page3072-3078(2013.12)

青枝大貴, 石井健. アジュバント添加新型インフルエンザワクチンはてんかんの危険因子ではない(解説) : MMJ 12月号 Vol.9 No.4 Page212-213 (2013.12).

特許関連

免疫賦活活性を有するオリゴヌクレオチド含有複合体及びその用途。石井健、小檜山康司、青枝大貴。特許出願2013-196206.

2012以前

Zhao H, Konishi A, Fujita Y, Yagi M, Ohata K, Aoshi T, Itagaki S, Sato S, Narita H, Abdelgelil NH, Inoue M, Culleton R, Kaneko O, Nakagawa A, Horii T, Akira S, Ishii KJ, Coban C. Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism. Cell Host Microbe. 2012 Nov 15; 12(5):705-16. doi: 10.1016/j.chom.2012.10.010.

Coban C, Kobiyama K, Aoshi T, Takeshita F, Horii T, Akira S, Ishii KJ. Novel strategies to improve DNA vaccine immunogenicity. Curr Gene Ther. 2011 Dec; 11(6):479-84.

Aoshi T, Koyama S, Kobiyama K, Akira S, Ishii KJ. Innate and adaptive immune responses to viral infection and vaccination. Curr Opin Virol. 2011 Oct; 1(4):226-32. doi: 10.1016/j.coviro.2011.07.002.

Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S. A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity. J Immunol. 2011 Jun 1; 186(11):6287-95. doi: 10.4049/jimmunol.1004036.

Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, KC W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, Murphy TL, Unanue ER, Murphy KM. CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes. Immunity. 2011 Aug 26; 35(2):236-48. doi: 10.1016/j.immuni.2011.06.012.

Ezoe H, Akeda Y, Piao Z, Aoshi T, Koyama S, Tanimoto T, Ishii KJ, Oishi K. Intranasal vaccination with pneumococcal surface protein A plus poly(I:C) protects against secondary pneumococcal pneumonia in mice. Vaccine. 2011 Feb 17; 29(9):1754-61. doi: 10.1016/j.vaccine.2010.12.117.

Koyama S,Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ. Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes. Sci Transl Med. 2010 Mar 31; 2(25):25ra24. doi: 10.1126/scitranslmed.3000759.

Coban C, Igari Y, Yagi M, Reimer T, Koyama S, Aoshi T, Ohata K, Tsukui T, Takeshita F, Sakurai K, Ikegami T, Nakagawa A, Horii T, Nuñez G, Ishii KJ, Akira S. Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9. Cell Host Microbe. 2010 Jan 21; 7(1):50-61. doi: 10.1016/j.chom.2009.12.003.

Otero K, Turnbull IR, Poliani PL, Vermi W, Cerutti E,Aoshi T, Tassi I, Takai T, Stanley SL, Miller M, Shaw AS, Colonna M. Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin. Nat Immunol. 2009 Jul; 10(7):734-43. doi: 10.1038/ni.1744.

Kobiyama K, Takeshita F, Ishii KJ, Koyama S, Aoshi T, Akira S, Sakaue-Sawano A, Miyawaki A, Yamanaka Y, Hirano H, Suzuki K, Okuda K. A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant. J Immunol. 2009 Feb 1; 182(3):1593-601.

Aoshi T, Carrero JA, Konjufca V, Koide Y, Unanue ER, Miller MJ. The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen. Eur J Immunol. 2009 Feb; 39(2):417-25. doi: 10.1002/eji.200838718.

Nagata T, Aoshi T, Uchijima M, Koide Y. In vivo hierarchy of individual T-cell epitope-specific helper T-cell subset against an intracellular bacterium. Vaccine. 2008 Sep 19; 26(40):5123-7. doi: 10.1016/j.vaccine.2008.03.061.

Aoshi T, Zinselmeyer BH, Konjufca V, Lynch JN, Zhang X, Koide Y, Miller MJ. Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. Immunity. 2008 Sep 19; 29(3):476-86. doi: 10.1016/j.immuni.2008.06.013.

Aoshi T, Nagata T, Suzuki M, Uchijima M, Hashimoto D, Rafiei A, Suda T, Chida K, Koide Y. Identification of an HLA-A*0201-restricted T-cell epitope on the MPT51 protein, a major secreted protein derived from Mycobacterium tuberculosis, by MPT51 overlapping peptide screening. Infect Immun. 2008 Apr; 76(4):1565-71. doi: 10.1128/IAI.01381-07.

Zinselmeyer BH, Lynch JN, Zhang X, Aoshi T, Miller MJ. Video-rate two-photon imaging of mouse footpad - a promising model for studying leukocyte recruitment dynamics during inflammation. Inflamm Res. 2008 Mar; 57(3):93-6. doi: 10.1007/s00011-007-7195-y.

Turnbull IR, Gilfillan S, Cella M, Aoshi T, Miller M, Piccio L, Hernandez M, Colonna M. Cutting edge: TREM-2 attenuates macrophage activation. J Immunol. 2006 Sep 15; 177(6):3520-4.

Nagata T, Uchijima M, Uchiyama H, Yamada T, Aoshi T, Koide Y. Immunization with a gene encoding granulocyte-macrophage colony-stimulating factor inserted with a single helper T-cell epitope of an intracellular bacterium induces a specific T-cell subset and protective immunity. Vaccine. 2006 May 22; 24(21):4548-53.

Nakano H, Nagata T, Suda T, Tanaka T, Aoshi T, Uchijima M, Kuwayama S, Kanamaru N, Chida K, Nakamura H, Okada M, Koide Y. Immunization with dendritic cells retrovirally transduced with mycobacterial antigen 85A gene elicits the specific cellular immunity including cytotoxic T-lymphocyte activity specific to an epitope on antigen 85A. Vaccine. 2006 Mar 15; 24(12):2110-9.

Aoshi T, Suzuki M, Uchijima M, Nagata T, Koide Y. Expression mapping using a retroviral vector for CD8+ T cell epitopes: definition of a Mycobacterium tuberculosis peptide presented by H2-Dd. J Immunol Methods. 2005 Mar; 298(1-2):21-34.

Uchijima M, Nagata T,Aoshi T, Koide Y. IFN-gamma overcomes low responsiveness of myeloid dendritic cells to CpG DNA. Immunol Cell Biol. 2005 Feb; 83(1):92-5.

Suzuki M, Aoshi T, Nagata T, Koide Y. Identification of murine H2-Dd- and H2-Ab-restricted T-cell epitopes on a novel protective antigen, MPT51, of Mycobacterium tuberculosis. Infect Immun. 2004 Jul; 72(7):3829-37.

Kageyama Y, Koide Y, Uchijima M, Nagata T, Yoshida A, Aoshi T, Miura T, Nagafusa T, Nagano A. Plasmid encoding interleukin-4 in the amelioration of murine collagen-induced arthritis. Arthritis Rheum. 2004 Mar; 50(3):968-75.

Tozawa K, Hanai H, Sugimoto K, Baba S, Sugimura H, Aoshi T, Uchijima M, Nagata T, Koide Y. Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice. J Gastroenterol Hepatol. 2003 May; 18(5):578-87.

Nakamura Y, Suda T, Nagata T, Aoshi T, Uchijima M, Yoshida A, Chida K, Koide Y, Nakamura H. Induction of protective immunity to Listeria monocytogenes with dendritic cells retrovirally transduced with a cytotoxic T lymphocyte epitope minigene. Infect Immun. 2003 Apr; 71(4):1748-54.

Uchiyama H, Nagata T, Yamada T, Uchijima M, Aoshi T, Suda T, Chida K, Nakamura H, Koide Y. Endosomal/lysosomal targeting of a single helper T-cell epitope of an intracellular bacterium by DNA immunisation induces a specific T-cell subset and partial protective immunity in vivo. FEMS Microbiol Lett. 2002 Oct 29; 216(1):91-7.Sugimoto K, Hanai H, Tozawa K, Aoshi T, Uchijima M, Nagata T, Koide Y. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology. 2002 Dec; 123(6):1912-22.

Nagata T, Aoshi T, Suzuki M, Uchijima M, Kim YH, Yang Z, Koide Y. Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chain. Infect Immun. 2002 May; 70(5):2676-80.

Nagata T, Higashi T, Aoshi T, Suzuki M, Uchijima M, Koide Y. Immunization with plasmid DNA encoding MHC class II binding peptide/CLIP-replaced invariant chain (Ii) induces specific helper T cells in vivo: the assessment of Ii p31 and p41 isoforms as vehicles for immunization. Vaccine. 2001 Oct 12; 20(1-2):105-14.

英語総説

Aoshi T, Koyama S, Kobiyama K, Akira S, Ishii KJ. Innate and adaptive immune responses to viral infection and vaccination. Curr Opin Virol. 2011 Oct; 1(4):226-32. doi: 10.1016/j.coviro.2011.07.002.

Koyama S, Coban C, Aoshi T, Horii T, Akira S, Ishii KJ. Innate immune control of nucleic acid-based vaccine immunogenicity. Expert Rev Vaccines. 2009 Aug; 8(8):1099-107. doi: 10.1586/erv.09.57.

Nagata T, Aoshi T, Uchijima M, Suzuki M, Koide Y. Cytotoxic T-lymphocyte-, and helper T-lymphocyte-oriented DNA vaccination. DNA Cell Biol. 2004 Feb; 23(2):93-106.

 

書籍など

免疫学Update分子病態の解明と治療への展開(審良静男, 熊ノ郷淳, 竹田潔／編). 第23章ワクチン開発研究の展開. 青枝大貴, 石井 健. 南山堂2012年12月.

免疫学コア講義(第3版) (熊ノ郷淳, 阪口薫雄, 竹田潔, 吉田裕樹／編). ワクチン. 青枝大貴, 石井 健. 南山堂2012年11月.

アジュバント開発研究の新展開(監修: 石井健・山西弘一). 第3章2.1インフルエンザウイルスの内因性アジュバント. 小山正平、青枝大貴、シーエムシー出版、2011年8月

完全版マウス・ラット疾患モデル活用ハンドブック(秋山徹，奥山隆平，河府和義／編). 第2 部　免疫10章 生体防御機構―Toll-like receptorsノックアウトマウス【青枝大貴／審良静男／石井　健】羊土社、2010年12月

日本語総説

青枝 大貴, 石井 健. 自然免疫の関わる病態と治療への応用　自然免疫研究と次世代ワクチン(解説/特集) : 医学のあゆみ(0039-2359)243巻1号 Page122-128(2012.10)

青枝 大貴, 石井 健. 自然免疫と次世代ワクチン開発(解説/特集) : Drug Delivery System(0913-5006)27巻1号 Page19-27(2012.01)

青枝 大貴, 石井 健. ワクチン基礎研究の最新動向と展望　ワクチンアジュバント(解説/特集) : 日本臨床(0047-1852)69巻9号 Page1547-1553(2011.09)

青枝 大貴, 石井 健. ワクチンを考えるうえで必要な免疫の知識(解説/特集) : 臨床検査(0485-1420)54巻11号 Page1220-1229(2010.10)

青枝 大貴. リステリア感染脾臓における宿主-病原体ダイナミクス(解説/特集) : 医学のあゆみ(0039-2359)232巻13号 Page1271-1276(2010.03)

青枝 大貴, 石井 健. DNAワクチンの基礎と作用機序(解説)：ファルマシア(0014-8601)45巻6号 Page531-535(2009.06)

青枝 大貴, 小山 正平, チョバン・ジェヴァイア , 石井 健. 感染症　DNAワクチンのあらたな免疫学的作用機序(解説/特集)：医学のあゆみ(0039-2359)227巻5号 Page387-392(2008.11)

小出 幸夫, 永田 年, 内嶋 雅人, 吉田 篤司, 青枝 大貴. 細胞内寄生菌感染に対するDNA(遺伝子)ワクチン(総説)：日本細菌学雑誌(0021-4930)54巻4号 Page773-793(1999.11)

特許関連

実験用小動物のための体温測定装置および体温測定方法。青枝大貴、石井健、長谷田泰成。特許出願2011-102045.

特許4883816 「結核菌に特異的なT細胞(CD8+)を検出するための方法」 小出幸夫、鈴木美奈、青枝大貴、永田年。 特許出願2009-278386．

特許4472307 「新規ペプチド及びこのペプチドから成る抗結核菌ワクチン」 小出幸夫、鈴木美奈、青枝大貴、永田年。 特許出願2003-372782．