教授プロフィール (大阪大学医学系研究科免疫再生制御学講座)
豊福 利彦 （とよふく としひこ）
Professor
Toshihiko Toyofuku, M.D., PhD.
略歴
昭和５７年に信州大学医学部卒業し、昭和６２年 信州大学大学院医学研究科にて医学博士を取得後、昭和６３年より米国シカゴ大学心臓部門研究員、平成３年よりカナダトロント大学バンチング・ベスト研究所研究員。平成６年に帰国し、平成１１年より大阪大学大学院医学系研究科助手 平成１３年より大阪大学大学院医学系研究科医学部講師、平成１６年 大阪大学微生物病研究所助教授（感染病態分野）にいたる。平成２６年４月から、免疫再生制御学講座の教授に就任。
主要論文
Toyofuku T, Nojima S, Ishikawa T, Takamatsu T, Tsujimura T, Uemura A, Matsuda J, Seki T,Kumanogoh A.
Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
Genes Dev. 26:816-29. 2012.
Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takamatsu H, Nojima S, Kimura T, Kang S, Ito D, Nakagawa Y, Toyofuku T, Takata K, Nakano M, Kubo M, Suzuki S, Matsui-Hasumi A, Uto-Konomi A, Ogata A, Mochizuki H, Sakoda S, and Kumanogoh A.
Elevation of Sema4A implicates T helper cell skewing and the efficacy of interferon-β therapy in multiple sclerosis.
J. Immunol. 188:4858-65.2012.
Kang S, Okuno T, Takegahara N, Takamatsu H, Nojima S, Kimura T, Yoshida Y, Ito D, Ohmae S, You DJ, Toyofuku T, Jang MH, Kumanogoh A.
Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via αvβ1 integrin.
J. Immunol. 188:1108-16.2012
Nakagawa Y, Takamatsu H, Okuno T, Kang S, Nojima S, Kimura T, Kataoka TR, Ikawa M, Toyofuku T, Katayama I, Kumanogoh A.
Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.
J. Immunol. 2011 Mar 1;186(5):2881-8.
Takegahara N, Kang S, Nojima S, Takamatsu H, Okuno T, Kikutani H, Toyofuku T, Kumanogoh A.
Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements.
FASEB J. 2010 Dec;24(12):4782-92.
Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A.
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.
Nat Immunol.2010 May 30, Advance on line publication.
Okuno T, Nakatsuji Y, Moriya M, Takamatsu H, Nojima S, Takegahara N, Toyofuku T, Nakagawa Y, Kang S, Friedel RH, Sakoda S, Kikutani K and Kumanogoh A.
Involvement of Sema4D-Plexin-B1 interactions in the CNS for pathogenesis of experimental autoimmune encephalomyelitis.
J. Immunol. 184: 1499-1506, 2010.
Makino N., T.Toyofuku, N.Takegahara, H.Takamatsu, T.Okuno, Y.Nakagawa, S.Kang, S.Nojima, M.Hori,H.Kikutani, A.Kumanogoh.
Involvment of Sema4A in the progressiono f experimental autoimmune myocarditis.
FEBS Lett. 582:3935-3940,2008
Toyofuku T., J.Yoshida , T. Sugimoto , M. Yamamoto , N. Makino ,
H. Takamatsu, N. Takegahara, F. Suto , M. Hori, H. Fujisawa, A. Kumanogoh, H. Kikutani.
Repulsive and attractive semaphorins cooperate to direct the navigation of cardiac neural crest cells.
Dev Biol. 321:251-262,2008
Toyofuku T., M. Yabuki, M. Kamei, M. Kamei, N. Makino,
A. Kumanogoh, and M. Hori.
Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis
via Plexin-D1.
EMBO J. 26: 1373-84, 2007
Takegahara N., H. Takamatsu, T. Toyofuku, T. Tsujimura, T.
Okuno, K. Yukawa, M. Mizui, M. Yamamoto, DVR. Prasad, K. Suzuki, M. Ishii, K. Terai, M.
Moriya, Y. Nakatsuji, S. Sakoda, S. Sato, S. Akira, K. Takeda, M. Inui, T. Takai, M. Ikawa,
M. Okabe, A. Kumanogoh*(* corresponding author) and H. Kikutani.
Plexin-A1 and its interaction with DAP12 in immune responses and bone
homeostasis.
Nat Cell Biol. 8: 615-622, 2006
Toyofuku T., J. Yoshida, T. Sugimoto, H. Zhang, A. Kumanogoh, M.
Hori and H. Kikutani.
The FERM domain contkaining GEF protein FARP2 triggers signals for Sema3A-mediated
axonal repulsion.
Nat Neurosci. 8: 1712-1719, 2005
Kumanogoh A., T. Shikina, C. Watanabe, N. Takegahara, K. Suzuki, M. Yamamoto, H. Takamatsu,
DV. Prasad, M. Mizui, T. Toyofuku, M. Tamura, D. Watanabe, JR. Parnes and H.
Kikutani.
Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor
signaling and homeostatic maintenance of the B-cell compartment.
Int. Immunol. 17: 1277-1282, 2005
Kumanogoh A., T. Shikina, K. Suzuki, S. Uematsu, K. Yukawa, S. Kashiwamura, H. Tsutsui, M. Yamamoto, H. Takamatsu, EP. Ko-Mitamura, N. Takegahara, S. Marukawa, I. Ishida, H. Morishita, DV Prasad, M. Tamura, M. Mizui, T. Toyofuku, S. Akira, K. Takeda, M. Okabe, and H. Kikutani H.
Nonredundant roles of Sema4A in the immune system: Defective T cell priming and
Th1/Th2 regulation in Sema4A-deficient mice.
Immunity 22: 305-16, 2005
Toyofuku T., H. Zhang, A. Kumanogoh, N. Takegahara, M. Yabuki, K. Harada, M. Hori, and H. Kikutani.
Guidance of myocardial patterning in cardiac development by Sema6D reverse
signalling.
Nat Cell Biol. 6: 1204-11, 2004
Hatanaka K., H. Kawata, T. Toyofuku, K. Yoshida.
Down-regulation of connexin43 in early myocardial ischemia and protective effect by
ischemic preconditioning in rat hearts in vivo.
Jpn Heart J 45:1007-19, 2004
Toyofuku T., H. Zhang, A. Kumanogoh, N. Takegahara, F. Suto, J. Kamei, K. Aoki, M. Yabuki, M. Hori, H. Fujisawa, and H. Kikutani.
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of
its receptor, Plexin-A1, with off-tack and vascular endothelial growth factor receptor type 2.
Genes Dev. 342: 157-64, 2004
Zhang H., T. Toyofuku, J. Kamei, M. Hori.
GATA-4 regulates cardiac morphogenesis through transactivation of the N-cadherin
gene.
Biochem Biophys Res Commun. 312:1033-8, 2003
Kamei J., T. Toyofuku, M. Hori.
Negative regulation of p21 by beta-catenin/TCF signaling: a novel mechanism by which
cell adhesion molecules regulate cell proliferation.
Biochem Biophys Res Commun. 312:380-7, 2003
Nakayama H., K. Otsu, O. Yamaguchi, K. Nishida, M. Date, K. Hongo, Y. Kusakari, T. Toyofuku, S. Hikoso, K. Kashiwase, H. Takeda, Y. Matsumura, S. Kurihara, M. Hori, and M. Tada.
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates
in vivo pressure overload cardiac hypertrophy.
FASEB J. 17:61-3, 2003
趣味
独身のころはたくさんあった。今は小学生の娘が喜ぶという理由で家族旅行（特に温泉）ぐらい
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