11/27(金)セミナー: Unlocking the Secrets of Longevity and Cancer Resistance in Bats
2026年10月20日
イベント・セミナー
|
演題 |
Unlocking the Secrets of Longevity and Cancer Resistance in Bats
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|---|---|
| 演者 |
板鼻 康至先生 （Associate Professor, Cancer & Stem Cell Biology Program Duke-NUS Medical School, Singapore） |
| 日時 |
11月27日(金) 14:00～15:30 |
| 場所 | 微研本館1F 微研ホール |
| 概要 | Bats exhibit exceptional longevity and cancer resistance despite their small body size, yet the underlying mechanisms remain elusive. We discovered that bats express extraordinarily high levels of ABCB1, a drug efflux transporter, across multiple tissues, protecting cells from genotoxic compounds. Unexpectedly, our recent studies using mice ubiquitously expressing bat ABCB1 revealed a previously unrecognized role in metabolic regulation, potentially contributing to metabolic resilience and longevity. Paradoxically, ABCB1 overexpression in human cancers drives multidrug resistance by reducing intracellular anticancer drug accumulation. To overcome this challenge, we have developed novel ABCB1 inhibitors inspired by bat biology, aiming to restore chemotherapy sensitivity. This seminar will discuss how bat studies may provide new insights into aging and inspire innovative cancer therapies. |
※本セミナーの使用言語は英語です。
※本セミナーは大学院医学系研究科及び生命機能研究科の単位認定セミナーです。
※お問合せ：原 英二（分子生物学分野分野 ehara＊biken-osaka-u.ac.jp）
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