Maternal Control of Mammalian Fertilization and Early Development

演題:　Maternal Control of Mammalian Fertilization and
　　　　Early Development

演者:　Professor Jurrien Dean
　　　　　 （Laboratory of Cellular and Developmental Biology,
　　　　　 　NIDDK, National Institutes of Health Building 50,
　　　　　 　Room 3134 Bethesda, MD 20892-8028, USA）

　The interregnum between transcription in fully-grown oocytes and activation of the embryonic genome dictates a role for maternal genes in early mouse embryogenesis.　 For successful development, eggs must be fertilized by a single sperm and cleavage-stage embryos must survive oviductal passage to implant on the uterine wall.　Two maternally-encoded matrices are critical for these events: the extracellular zona pellucida that surrounds the ovulated egg and the intracellular subcortical maternal complex (SCMC), each of which is formed during oogenesis and persists in the early blastocyst.　Using mouse transgenesis to perturb these matrices, the molecular basis of gamete recognition has been redefined and the role of the SCMC investigated.　Ablation of individual components results in delayed or arrested cleavage stage development and localization of the SCMC in morulae and blastocyst is consistent with a role in the initial establishment of embryonic cell lineages.　The absence of either maternal complex results in embryonic death.

日時:　　　２０１1年１２月１２日（月）１７：００～１８：００
Date & Time: December 12th, Monday, From 5 p.m. to 6 p.m., 2011

場所:　 微生物病研究所　本館１階　微研ホール
Locatin: Biken Hall, 1st Floor, Biken Main Building

連絡先:　遺伝子機能解析分野
　　　 　　井上 直和
　　　 　　TEL:　06-6879-8375