21) Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol. 2006 Aug 28; [Epub ahead of print]
20) Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol. 2006 Jul 23; [Epub ahead of print]
19) Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J. TAK1 is a master regulator
of epidermal homeostasis involving skin inflammation and apoptosis. J Biol
Chem. 2006 May 4; [Epub ahead of print]
18) Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG, Rose DW. Macrophage/Cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway. Cell. 2006 Feb 10;124(3):615-29.
17) Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B. J Biol Chem. 2006 Jan 30; [Epub ahead of print]
16) Sato S*, Sanjo H*, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S (*equal contribution). Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005 Sep 25; [Epub ahead of print]
15) Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J. TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells. 2005 May;10(5):447-54.
14) Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S. The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50.
13) Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway. Science. 2003 Jul 10 [Epub ahead of print]
12) Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S. TAB2 Is
Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1
Signaling. Mol Cell Biol. 2003 Feb 15;23(4):1231-1238.
11) Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda
K, Akira S. Essential role for TIRAP in activation of the signalling cascade
shared by TLR2 and TLR4. Nature. 2002 Nov 21;420(6913):324-329.
10) Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. Small anti-viral
compounds activate immune cells via the TLR7 MyD88-dependent signaling
pathway. Nat Immunol. 2002 Feb;3(2):196-200.
9). Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo
H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A
Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec
7;408(6813):740-5.
8) Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S. Differential roles of TLR2 and
TLR4 in recognition of gram-negative and gram-positive bacterial cell wall
components. Immunity. 1999, 11:443-51.
7) Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. A novel LPS-inducible C-type
lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol.
1999, 163:5039-48.
6) Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S. TLR6: A novel
member of an expanding toll-like receptor family. Gene. 1999, 231:59-65.
5) Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S. Cutting edge: Toll-like receptor
4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence
for TLR4 as the Lps gene product. J Immunol.,162:3749-52.
4) Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S. Limb and skin abnormalities in mice lacking
IKKalpha. Science. 1999, 284:313-6.
3) Kawai T, Sanjo H, Akira S. Duet is a novel serine/threonine kinase with Dbl-Homology (DH)
and Pleckstrin-Homology (PH) domains. Gene. 1999, 227:249-55.
2) Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated
protein kinase that trigger apoptosis. J Biol Chem. 1998, 273:29066-71.
1) Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Mol Cell Biol. 1998, 18:1642-51.