65) Kamon H, Kawabe T, Kitamura H, Lee J, Kamimura D, Kaisho T, Akira S, Iwamatsu A, Koga H, Murakami M, Hirano T. TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J. 2006 Sep 6;25(17):4108-19. Epub 2006 Aug 17.

64) Kitamura H, Morikawa H, Kamon H, Iguchi M, Hojyo S, Fukada T, Yamashita S, Kaisho T, Akira S, Murakami M, Hirano T. Toll-like receptor-mediated regulation of zinc homeostasis influences dendritic cell function. Nat Immunol. 2006 Aug 6; [Epub ahead of print]

63) Kaisho T, Akira S. Toll-like receptor function and signaling. J Allergy Clin Immunol. 2006 May;117(5):979-87; quiz 988. Epub 2006 Apr 3.

62) Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, Hemmi H, Ohara O, Akira S, Kaisho T. IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature. 2006 Apr 13;440(7086):949-53.

61) Kinoshita D, Hirota F, Kaisho T, Kasai M, Izumi K, Bando Y, Mouri Y, Matsushima A, Niki S, Han H, Oshikawa K, Kuroda N, Maegawa M, Irahara M, Takeda K, Akira S, Matsumoto M. Essential Role of I{kappa}B Kinase {alpha} in Thymic Organogenesis Required for the Establishment of Self-Tolerance. J Immunol. 2006 Apr 1;176(7):3995-4002.

60) Kanemitsu N, Ebisuno Y, Tanaka T, Otani K, Hayasaka H, Kaisho T, Akira S, Katagiri K, Kinashi T, Fujita N, Tsuruo T, Miyasaka M. CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood. 2005 Jun 21; [Epub ahead of print]

59) Nagai Y, Kobayashi T, Motoi Y, Ishiguro K, Akashi S, Saitoh S, Kusumoto Y, Kaisho T, Akira S, Matsumoto M, Takatsu K, Miyake K. The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes. J Immunol. 2005 Jun 1;174(11):7043-9.

58) Sugiyama T, Gursel M, Takeshita F, Coban C, Conover J, Kaisho T, Akira S, Klinman DM, Ishii KJ. CpG RNA: Identification of Novel Single-Stranded RNA That Stimulates Human CD14+CD11c+ Monocytes. J Immunol. 2005 Feb 15;174(4):2273-9.

57) Kaisho T, Akira S. Pleiotropic function of Toll-like receptors. Microbes Infect. 2004 Dec;6(15):1388-94.
mechanism. J Immunol. 2004 Dec 15;173(12):7416-25.

56) Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004 Jul 8;430(6996):218-22.

55) Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S. The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50.

54) Diebold SS, Kaisho T, Hemmi H, Akira S, Reis E Sousa C. Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA. Science. 2004 Feb 19 [Epub ahead of print]

53) Kaisho T, Akira S. Regulation of dendritic cell function through toll-like receptors. Curr Mol Med. 2003 Dec;3(8):759-71.

52) Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Oct 12 [Epub ahead of print]

51) Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, Taniguchi T. Selective contribution of IFN-{alpha}/{beta} signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A. 2003 Sep 5 [Epub ahead of print]

50) Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K, Akira S. IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-{alpha} production in macrophages. Blood. 2003 Aug 7 [Epub ahead of print]

49) Ebisuno Y, Tanaka T, Kanemitsu N, Kanda H, Yamaguchi K, Kaisho T, Akira S, Miyasaka M. Cutting Edge: The B Cell Chemokine CXC Chemokine Ligand 13/B Lymphocyte Chemoattractant Is Expressed in the High Endothelial Venules of Lymph Nodes and Peyer's Patches and Affects B Cell Trafficking Across High Endothelial Venules. J Immunol. 2003 Aug 15;171(4):1642-1646.

48) Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway. Science. 2003 Aug 1;301(5633):640-3.

47) Kaisho T, Akira S. Regulation of dendritic cell function through Toll-like receptors. Curr Mol Med. 2003 Jun;3(4):373-85.

46) Edwards AD, Diebold SS, Slack EM, Tomizawa H, Hemmi H, Kaisho T, Akira S, Sousa CR. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol. 2003 Apr;33(4):827-33.

45) Hemmi H, Kaisho T, Takeda K, Akira S. The Roles of Toll-Like Receptor 9, MyD88, and DNA-Dependent Protein Kinase Catalytic Subunit in the Effects of Two Distinct CpG DNAs on Dendritic Cell Subsets. J Immunol. 2003 Mar 15;170(6):3059-3064.

44). Takeda K, Kaisho T, Akira S. Toll-Like Receptors. Annu Rev Immunol. 2003;21:335-76.

43) Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002 Nov 21;420(6913):324-329.

42) Hoshino K, Kaisho T, Iwabe T, Takeuchi O, Akira S. Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. Int Immunol. 2002 Oct;14(10):1225-1231.

41) Edwards AD, Manickasingham SP, Sporri R, Diebold SS, Schulz O, Sher A, Kaisho T, Akira S, Reis E Sousa C. Microbial Recognition Via Toll-Like Receptor-Dependent and -Independent Pathways Determines the Cytokine Response of Murine Dendritic Cell Subsets to CD40 Triggering. J Immunol. 2002 Oct 1;169(7):3652-3660.

40) Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S. Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int Immunol. 2002 Jul;14(7):695-700.

39) Ito T, Amakawa R, Kaisho T, Hemmi H, Tajima K, Uehira K, Ozaki Y, Tomizawa H, Akira S, Fukuhara S. Interferon-alpha and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets. J Exp Med. 2002 Jun 3;195(11):1507-1512.

38) Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta. 2002 Feb 13;1589(1):1-13.

37) Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200.

36) Kaisho T, Akira S. Bug detectors. Nature. 2001 Dec 13;414(6865):701-703. No abstract available.

35) Kaisho T, Akira S. Toll-like receptors and their signaling mechanism in innate immunity. Acta Odontol Scand. 2001 Jun;59(3):124-30.

34) Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001 Aug;2(8):675-80.

33) Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S. Endotoxin-Induced Maturation of MyD88-Deficient Dendritic Cells. J Immunol. 2001 May 1;166(9):5688-5694.

32) Kaisho T, Akira S. Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol. 2001 Feb 1;22(2):78-83.

31) Matsushima A, Kaisho T, Rennert PD, Nakano H, Kurosawa K, Uchida D, Takeda K, Akira S, Matsumoto M. Essential Role of Nuclear Factor (NF)-kappaB-inducing Kinase and Inhibitor of kappaB (IkappaB) Kinase alpha in NF-kappaB Activation through Lymphotoxin beta Receptor, but Not through Tumor Necrosis Factor Receptor I. J Exp Med. 2001 Mar 5;193(5):631-636.

30) Kaisho T, Takeda K, Tsujimura T, Kawai T, Nomura F, Terada N, Akira S. IkappaB Kinase alpha Is Essential for Mature B Cell Development and Function. J Exp Med. 2001 Feb 19;193(4):417-426.

29) Kaisho T, Akira S. Critical roles of toll-like receptors in host defense. Crit Rev Immunol. 2000;20(5):393-405.

28) Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S. A Toll-like receptor recognizes bacterial DNA. Nature. 2000 Dec 7;408(6813):740-5.

27) Hashimoto A, Takeda K, Inaba M, Sekimata M, Kaisho T, Ikehara S, Homma Y, Akira S, Kurosaki T. Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function. J Immunol. 2000 Aug 15;165(4):1738-42.

26) Kaisho T, Tsutsui H, Tanaka T, Tsujimura T, Takeda K, Kawai T, Yoshida N, Nakanishi K, Akira S. Impairment of natural killer cytotoxic activity and interferon gamma production in CCAAT/enhancer binding protein gamma-deficient mice. J Exp Med. 1999, 190:1573-82.

25) Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol. 1999, 163:5039-48.

24) Sakao Y, Takeda K, Tsutsui H, Kaisho T, Nomura F, Okamura H, Nakanishi K, Akira S . IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. Int Immunol. 1999, 11:471-80.

23) Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Forster I, Akira S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 1999, 10:39-49.

22) Tsujimura T, Hashimoto K, Kitayama H, Ikeda H, Sugahara H, Matsumura I, Kaisho T, Terada N, Kitamura Y, Kanakura Y. Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site. Blood. 1999, 93:1319-29.

21) Akaishi H, Takeda K, Kaisho T, Shineha R, Satomi S, Takeda J, Akira S. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. Int Immunol. 1998, 10:1747-51.

20) Takeda K, Kaisho T, Yoshida N, Takeda J, Kishimo to T, Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol. 1998, 161:4652-60.

19) Kaisho T. [Membrane-bound IgG1 is involved in in vivo immune responses through the cytoplasmic tail]. Tanpakushitsu Kakusan Koso. 1998, 43:119-26.

18) Kaisho T, Schwenk F, Rajewsky K. The roles of gamma 1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses. Science. 1997, 276:412-5.

17) Lee BO, Ishihara K, Denno K, Kobune Y, Itoh M, Muraoka O, Kaisho T, Sasaki T, Ochi T, Hirano T. Elevated levels of the soluble form of bone marrow stromal cell antigen 1 in the sera of patients with severe rheumatoid arthritis. Arthritis Rheum. 1996, 39:629-37.

16) Kajimoto Y, Miyagawa J, Ishihara K, Okuyama Y, Fujitani Y, Itoh M, Yoshida H, Kaisho T, Matsuoka T, Watada H, Hanafusa T, Yamasaki Y, Kamada T, Matsuzawa Y, Hirano T. Pancreatic islet cells express BST-1, a CD38-like surface molecule having ADP-ribosyl cyclase activity. Biochem Biophys Res Commun. 1996, 219:941-6.

15) Sanceau J, Kaisho T, Hirano T, Wietzerbin J. Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors. J Biol Chem. 1995, 270:27920-31.

14) Clark EA, Grabstein KH, Gown AM, Skelly M, Kaisho T, Hirano T, Shu GL. Activation of B lymphocyte maturation by a human follicular dendritic cell line, FDC-1. J Immunol. 1995, 155:545-55.

13) Ishikawa J, Kaisho T, Tomizawa H, Lee BO, Kobune Y, Inazawa J, Oritani K, Itoh M, Ochi T, Ishihara K, et al. Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. Genomics. 1995, 26:527 -34.

12) Hirata Y, Kimura N, Sato K, Ohsugi Y, Takasawa S, Okamoto H, Ishikawa J, Kaisho T, Ishihara K, Hirano T. ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1. FEBS Lett. 1994, 356:244-8.

11) Itoh M, Ishihara K, Tomizawa H, Tanaka H, Kobune Y, Ishikawa J, Kaisho T, Hirano T. Molecular cloning of murine BST-1 having homology with CD38 and Aplysia ADP-ribosyl cyclase. Biochem Biophys Res Commun. 1994, 203:1309-17.

10) Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O, Ochi T, Hirano T. BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth. Proc Natl Acad Sci U S A. 1994, 91:5325-9.

9) Nagasawa T, Kaisho T, Kishimoto T, Kikutani H. Generation and characterization of a monoclonal antibody that inhibits stromal cell-dependent B lymphopoiesis. J Immunol. 1994, 152:2788-97.

8) Muraoka O, Kaisho T, Tanabe M, Hirano T. Transcriptional activation of the interleukin-6 gene by HTLV-1 p40tax through an NF-kappa B-like binding site. Immunol Lett. 1993, 37:159-65 .

7) Brach MA, Gruss HJ, Kaisho T, Asano Y, Hirano T, Herrmann F. Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B. J Biol Chem. 1993, 268:8466-72.

6) Kaisho T, Oritani K, Ishikawa J, Tanabe M, Muraoka O, Ochi T, Hirano T. Human bone marrow stromal cell lines from myeloma and rheumatoid arthritis that can support murine pre-B cell growth. J Immunol. 1992, 149:4088-95.

5) Oritani K, Kaisho T, Nakajima K, Hirano T. Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6. Blood. 1992, 80:2298-305.

4) Kaisho T, Nagasawa T, Kishimoto T, Kikutani H. A stromal cell-specific monoclonal antibody augments the stromal cell-dependent B lymphopoiesis. J Immunol. 1992, 148:989-95.

3) Kaisho T, Hirano T. [Interleukin 6 and disease]. Ryumachi. 1991, 31:318-26.

2) Inui S, Kaisho T, Kikutani H, Stamenkovic I, Seed B, Clark EA, Kishimoto T. Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40. Eur J Immunol. 1990, 20:1747-53.

1) Kikutani H, Inui S, Sato R, Barsumian EL, Owaki H, Yamasaki K, Kaisho T, Uchibayashi N, Hardy RR, Hirano T, et al. Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell. 1986, 47:657-65.