Ue

92) Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM, Yoshida M. Toll-Like 2 Receptor Mediates Apolipoprotein CIII-Induced Monocyte Activation. Circ Res. 2008 Oct 30. [Epub ahead of print]

91) Saitoh T*, Fujita N*, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008 Oct 5. [Epub ahead of print] (*contributed equally)

90) Zhu Q, Egelston C, Vivekanandhan A, Uematsu S, Akira S, Klinman DM, Belyakov IM, Berzofsky JA. Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: Implications for vaccines. Proc Natl Acad Sci U S A. 2008 Oct 9. [Epub ahead of print]

89) Baragatti B, Sodini D, Uematsu S, Coceani F.Role of Microsomal Prostaglandin E Synthase-1 (Mpges1)-Derived Pge2 in Patency of the Ductus Arteriosus in the Mouse. Pediatr Res. 2008 Jul 3. [Epub ahead of print]

88) Santiago-Raber ML, Kikuchi S, Borel P, Uematsu S, Akira S, Kotzin BL, Izui S. Evidence for genes in addition to tlr7 in the yaa translocation linked with acceleration of systemic lupus erythematosus. J Immunol. 2008 Jul 15;181(2):1556-62.

87) Uematsu S*, Fujimoto K*, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol. 2008 May 30. [Epub ahead of print] (*contributed equally)

86) Elander N, Ungerb?ck J, Olsson H, Uematsu S, Akira S, S?derkvist P. Genetic deletion of mPGES-1 accelerates intestinal tumorigenesis in APC(Min/+) mice. Biochem Biophys Res Commun. 2008 May 14. [Epub ahead of print]

85) Zucchini N, Bessou G, Traub S, Robbins SH, Uematsu S, Akira S, Alexopoulou L, Dalod M. Cutting Edge: Overlapping Functions of TLR7 and TLR9 for Innate Defense against a Herpesvirus Infection. J Immunol. 2008 May 1;180(9):5799-5803.

84) Shin OS, Isberg R, Akira S, Uematsu S, Behera AK, Hu LT. Distinct roles for MyD88, TLR2, TLR5, and TLR9 in phagocytosis of Borrelia burgdorferi and inflammatory signaling. Infect Immun. 2008 Mar 31; [Epub ahead of print]

83) Hirata N, Yanagawa Y, Ebihara T, Seya T, Uematsu S, Akira S, Hayashi F, Iwabuchi K, Ono? K. Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells. Mol Immunol. 2008 Mar 25; [Epub ahead of print]

82) Ishii KJ*, Kawagoe T*, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S. TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature. 2008 Feb 7;451(7179):725-729. (*contributed equally)

81) Zhang B, Ramesh G, Uematsu S, Akira S, Reeves WB. TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity. J Am Soc Nephrol. 2008 Feb 6; [Epub ahead of print]

80) Nakano Y, Kuroda E, Kito T, Uematsu S, Akira S, Yokota A, Nishizawa S, Yamashita U. Induction of prostaglandin E(2) synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. J Neurosurg. 2008 Feb;108(2):311-319.

79) Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN. Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity. J Immunol. 2008 Feb 1;180(3):1609-18.

78) Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S, Gewirtz AT. TLR5KO mice have dysregulated intestinal gene expression and non-specific resistance to Salmonella-induced typhoid-like disease. Infect Immun. 2008 Jan 14; [Epub ahead of print]

77) Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H. Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders. Arthritis Rheum. 2007 Dec 28;58(1):172-183 [Epub ahead of print]

76) Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie CC. Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2. J Biol Chem. 2007 Dec 14; [Epub ahead of print]

75) Uematsu S, Akira S. Toll-Like Receptors (TLRs) and Their Ligands. Handb Exp Pharmacol. 2008;183:1-20.

74) Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S , Akira S, Williams IR, Gewirtz AT. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest. 2007 Nov 15; [Epub ahead of print]

73) Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ. Altered Inflammatory Responses in TLR5-Deficient Mice Infected with Legionella pneumophila. J Immunol. 2007 Nov 15;179(10):6981-7.

72) Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, Yamamoto M, Yoshimori T, Akira S. The C/EBPbeta Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated Gene Induction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing. J Immunol. 2007 Oct 15;179(8):5378-86.

71) Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S. Differential Role of TLR- and RLR-Signaling in the Immune Responses to Influenza A Virus Infection and Vaccination. J Immunol. 2007 Oct 1;179(7):4711-20.

70) Bevelander M, Mayette J, Whittaker LA, Paveglio SA, Jones CC, Robbins J, Hemenway D, Akira S, Uematsu S, Poynter ME. Nitrogen dioxide promotes allergic sensitization to inhaled antigen. J Immunol. 2007 Sep 15;179(6):3680-8.

69) Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med. 2007 Aug 27; [Epub ahead of print]

68) Li J, Song W, Czerwinski DK, Varghese B, Uematsu S, Akira S, Krieg AM, Levy R. Lymphoma Immunotherapy with CpG Oligodeoxynucleotides Requires TLR9 Either in the Host or in the Tumor Itself. J Immunol. 2007 Aug 15;179(4):2493-500.

67) Kuroda E, Noguchi J, Doi T, Uematsu S, Akira S, Yamashita U. IL-3 is an important differentiation factor for the development of prostaglandin E(2)-producing macrophages between C57BL/6 and BALB/c mice. Eur J Immunol. 2007 Jul 12; [Epub ahead of print]

66) Saha S, Takeshita F, Matsuda T, Jounai N, Kobiyama K, Matsumoto T, Sasaki S, Yoshida A, Xin KQ, Klinman DM, Uematsu S, Ishii KJ, Akira S, Okuda K. Blocking of the TLR5 Activation Domain Hampers Protective Potential of Flagellin DNA Vaccine. J Immunol. 2007 Jul 15;179(2):1147-54.

65) Shim DH, Chang SY, Park SM, Jang H, Carbis R, Czerkinsky C, Uematsu S, Akira S, Kweon MN. Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a. Vaccine. 2007 Apr 20; [Epub ahead of print]

64) Ramesh G, Zhang B, Uematsu S, Akira S, Reeves WB. Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Am J Physiol Renal Physiol. 2007 May 9; [Epub ahead of print]

62) Andersen-Nissen E, Hawn TR, Smith KD, Nachman A, Lampano AE, Uematsu S, Akira S, Aderem A. Cutting Edge: Tlr5-/- Mice Are More Susceptible to Escherichia coli Urinary Tract Infection. J Immunol. 2007 Apr 15;178(8):4717-20.

61) Uematsu S, Akira S. Toll-like Receptors and Type I Interferons. J Biol Chem. 2007 May 25;282(21):15319-23. [Epub 2007 Mar 29].

60) Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG. Deficiencies of Myeloid differentiation factor 88, Toll-like receptor (TLR)-2, or TLR4 produce specific defects in macrophage cytokine
secretion induced by Helicobacter pylori. Infect Immun. 2007 Mar 12; [Epub ahead of print]

59) Heer AK, Shamshiev A, Donda A, Uematsu S, Akira S, Kopf M, Marsland BJ. TLR Signaling Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector T Cell Responses. J Immunol. 2007 Feb 15;178(4):2182-91.

58) Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S. Pathological role of Toll-like receptor signaling in cerebral malaria. Int Immunol. 2006 Nov 29; [Epub ahead of print]

57) Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S. Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling. J Immunol. 2006 Dec 1;177(11):7520-4.

56) Ishii KJ, Uematsu S, Akira S. 'Toll' gates for future immunotherapy. Curr Pharm Des. 2006;12(32):4135-42.

55) Matsui K, Kumagai Y, Kato H, Sato S, Kawagoe T, Uematsu S, Takeuchi O, Akira S. Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells. J Immunol. 2006 Nov 1;177(9):5785-9.

54) Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S. VP1686, a Vibrio type III secretion protein, induces toll-like receptor independent apoptosis in macrophage through NF-kappa B inhibition. J Biol Chem. 2006 Sep 19; [Epub ahead of print]

53) Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S, Akira S, Wang CR, Fairchild RL, Alegre ML, Chong A. TLR Engagement Prevents Transplantation Tolerance. Am J Transplant. 2006 Oct;6(10):2282-91.

52) Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med. 2006 Aug 10; [Epub ahead of print]

51) Kim L, Butcher BA, Lee CW, Uematsu S , Akira S, Denkers EY. Toxoplasma gondii Genotype Determines MyD88-Dependent Signaling in Infected Macrophages. J Immunol. 2006 Aug 15;177(4):2584-91.

50) Wuest T, Austin BA, Uematsu S, Thapa M, Akira S, Carr DJ. Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10. J Neuroimmunol. 2006 Jul 31; [Epub ahead of print]

49) Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T. CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation. Mol Cell Biol. 2006 Aug;26(16):6105-16.

48) Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y. Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11790-5. Epub 2006 Jul 24.

47) Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol. 2006 Jul 23; [Epub ahead of print]

46) Inada M, Matsumoto C, Uematsu S, Akira S, Miyaura C. Membrane-bound prostaglandin e synthase-1-mediated prostaglandin e2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol. 2006 Aug 1;177(3):1879-85.

45) Uematsu S*, Jang MH*, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S (*equal contribution). Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c(+) lamina propria cells. Nat Immunol. 2006 Jul 9; [Epub ahead of print]

44) Behera AK, Hildebrand E, Uematsu S , Akira S, Coburn J, Hu LT. Identification of a TLR-Independent Pathway for Borrelia burgdorferi-Induced Expression of Matrix Metalloproteinases and Inflammatory Mediators through Binding to Integrin {alpha}3beta1. J Immunol. 2006 Jul 1;177(1):657-64.

43) Kumar H*, Kawai T*, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S (*equal contribution). Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med. 2006 Jun 19; [Epub ahead of print]

42) Cottalorda A, Verschelde C, Marcais A, Tomkowiak M, Musette P, Uematsu S, Akira S, Marvel J, Bonnefoy-Berard N. TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen-induced T cell activation. Eur J Immunol. 2006 Jun 8; [Epub ahead of print]

41) Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita T, Akira S. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006 Apr 9; [Epub ahead of print]

40) Barrier M, Lacroix-Lamande S, Mancassola R, Auray G, Bernardet N, Chausse AM, Uematsu S, Akira S, Laurent F. Oral and Intraperitoneal Administration of Phosphorothioate Oligodeoxynucleotides Leads to Control of Cryptosporidium parvum Infection in Neonatal Mice. J Infect Dis. 2006 May 15;193(10):1400-7. Epub 2006 Apr 10.

39) Rumio C, Besusso D, Arnaboldi F, Palazzo M, Selleri S, Gariboldi S, Akira S, Uematsu S, Bignami P, Ceriani V, Menard S, Balsari A. Activation of smooth muscle and myenteric plexus cells of jejunum via toll-like receptor 4. J Cell Physiol. 2006 Mar 7; [Epub ahead of print]

38) Uematsu S, Akira S. The role of Toll-like receptors in immune disorders. Expert Opin Biol Ther. 2006 Mar;6(3):203-14.

37) Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006 Feb 24;124(4):783-801.

36) Behera AK, Hildebrand E, Bronson RT, Perides G, Uematsu S, Akira S, Hu LT. MyD88 Deficiency Results in Tissue-Specific Changes in Cytokine Induction and Inflammation in Interleukin-18-Independent Mice Infected with Borrelia burgdorferi. Infect Immun. 2006 Mar;74(3):1462-70.

35) Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC. Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta -glucan receptor. J Biol Chem. 2006 Jan 3; [Epub ahead of print]

34) Rogers KA, Rogers AB, Leav BA, Sanchez A, Vannier E, Uematsu S, Akira S, Golenbock D, Ward HD. MyD88-Dependent Pathways Mediate Resistance to Cryptosporidium parvum Infection in Mice. Infect Immun. 2006 Jan;74(1):549-56.

33) Bhattacharjee RN, Park KS, Uematsu S , Okada K, Hoshino K, Takeda K, Takeuchi O, Akira S, Iida T, Honda T. Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest. FEBS Lett. 2005 Nov 9; [Epub ahead of print]

32) Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol. 2005 Nov 13; [Epub ahead of print]

31) Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM. Corrigendum: Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med. 2005 Nov;11(11):1256. No abstract available.

30) Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med. 2005 Oct 17;202(8):1131-9.

29) Baratin M, Roetynck S, Lepolard C, Falk C, Sawadogo S, Uematsu S, Akira S, Ryffel B, Tiraby JG, Alexopoulou L, Kirschning CJ, Gysin J, Vivier E, Ugolini S. Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14747-52. Epub 2005 Oct 3.

28) Bhattacharjee RN, Park KS, Okada K, Kumagai Y, Uematsu S, Takeuchi O, Akira S, Iida T, Honda T. Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus. Biochem Biophys Res Commun. 2005 Jul 29; [Epub ahead of print]

27) Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S. Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity. 2005 Jul;23(1):19-28.

26) de Jonge WJ, van der Zanden EP, The FO, Bijlsma MF, van Westerloo DJ, Bennink RJ, Berthoud HR, Uematsu S , Akira S, van den Wijngaard RM, Boeckxstaens GE. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol. 2005 Aug;6(8):844-51. Epub 2005 Jul 17.

25) Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y. Microglia-specific expression of microsomal prostaglandin E synthase-1 contributes to lipopolysaccharide-induced prostaglandin E production. J Neurochem. 2005 Jul 5; [Epub ahead of print]

24) Yang R, Murillo FM, Delannoy MJ, Blosser RL, Yutzy WH 4th, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB. B Lymphocyte Activation by Human Papillomavirus-Like Particles Directly Induces Ig Class Switch Recombination via TLR4-MyD88. J Immunol. 2005 Jun 15;174(12):7912-9.

23) Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M, Azuma I, Toyoshima K, Kusumoto S, Seya T. Dendritic Cell Maturation Induced by Muramyl Dipeptide (MDP) Derivatives: Monoacylated MDP Confers TLR2/TLR4 Activation. J Immunol. 2005 Jun 1;174(11):7096-103.

22) Yang R, Wheeler CM, Chen X, Uematsu S , Takeda K, Akira S, Pastrana DV, Viscidi RP, Roden RB. Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer. J Virol. 2005 Jun;79(11):6741-50.

21) Henneke P, Morath S, Uematsu S, Weichert S, Pfitzenmaier M, Takeuchi O, Muller A, Poyart C, Akira S, Berner R, Teti G, Geyer A, Hartung T, Trieu-Cuot P, Kasper DL, Golenbock DT. Role of lipoteichoic Acid in the phagocyte response to group B streptococcus. J Immunol. 2005 May 15;174(10):6449-55.

20) Kumanogoh A, Shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatsu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DV, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani H. Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice. Immunity. 2005 Mar;22(3):305-16.

19) Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med. 2005 Mar 14; [Epub ahead of print]

18) Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med. 2005 Mar;11(3):263-70. Epub 2005 Feb 20.

17) Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I, Takeuchi O, Akira S. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochem Biophys Res Commun. 2005 Mar 11;328(2):383-92.

16) Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nat Med. 2005 Jan 16; [Epub ahead of print]

15) Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med. 2005 Jan 3;201(1):19-25.

14) Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, Akira S, Woods AS, Gowda DC. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum: Cell signaling receptors, GPI structural requirement, and regulation of GPI activity. J Biol Chem. 2004 Dec 28; [Epub ahead of print]

13) Yang R, Murillo FM, Cui H, Blosser R, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB. Papillomavirus-like particles stimulate murine bone marrow-derived dendritic cells to produce alpha interferon and Th1 immune responses via MyD88. J Virol. 2004 Oct;78(20):11152-60.

12) Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira S. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004 Sep 7 [Epub ahead of print]

11) Jang S, Uematsu S, Akira S, Salgame P. IL-6 and IL-10 induction from dendritic cells in response to Mycobacterium tuberculosis is predominantly dependent on TLR2-mediated recognition. J Immunol. 2004 Sep 1;173(5):3392-7.

10) Yang R, Murillo FM, Lin KY, Yutzy WH 4th, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB. Human papillomavirus type-16 virus-like particles activate complementary defense responses in key dendritic cell subpopulations. J Immunol. 2004 Aug 15;173(4):2624-31.

9) Yamamoto M, Yamazaki S, Uematsu S , Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004 Jul 8;430(6996):218-22.

8) Mabuchi T, Kojima H, Abe T, Takagi K, Sakurai M, Ohmiya Y, Uematsu S, Akira S, Watanabe K, Ito S. Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain. Neuroreport. 2004 Jun 28;15(9):1395-1398.

7) Kamei D, Yamakawa K, Takegoshi Y, Mikami-Nakanishi M, Nakatani Y, Oh-Ishi S, Yasui H, Azuma Y, Hirasawa N, Ohuchi K, Kawaguchi H, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Kudo I. Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin E synthase-1. J Biol Chem. 2004 May 12 [Epub ahead of print]

6). Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol. 2003 Oct 12 [Epub ahead of print]

5) Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL. Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med. 2003 Apr 14 [epub ahead of print]

4) Girard R, Pedron T, Uematsu S, Balloy V, Chignard M, Akira S, Chaby R. Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow granulocytes via Toll-like receptor 2. J Cell Sci. 2003 Jan 15;116(Pt 2):293-302.

3) Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 2002 Nov 21;420(6913):324-329.

2) Kim J, Ochoa MT, Krutzik SR, Takeuchi O, Uematsu S, Legaspi AJ, Brightbill HD, Holland D, Cunliffe WJ, Akira S, Sieling PA, Godowski PJ, Modlin RL. Activation of Toll-Like Receptor 2 in Acne Triggers Inflammatory Cytokine Responses. J Immunol. 2002 Aug 1;169(3):1535-1541.

1) Uematsu S, Matsumoto M, Takeda K, Akira S. Lipopolysaccharide-Dependent Prostaglandin E(2) Production Is Regulated by the Glutathione-Dependent Prostaglandin E(2) Synthase Gene Induced by the Toll-Like Receptor 4/MyD88/NF-IL6 Pathway. J Immunol. 2002 Jun 1;168(11):5811-5816.