Research Center for Infectious Disease Control

Department of Bacterial Infections

Research Group / Research Projects / Major publications /

Research Group

ProfessorTetsuya Iida
Associate ProfessorToshio Kodama
Assistant ProfessorShigeaki Matsuda

Research Projects

Figure 1. Whole genome sequence of
Vibrio parahaemolyticus

Figure 2. Characterization and comparison of the genomes of pathogenic bacteria by using DNA microarrays

This research group is studying pathogenic bacteria from the genomic point of view.

Our main research targets are as follows:
1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression: To understand the molecular mechanisms by which bacterial pathogens infect host organisms, we are using DNA microarrays and other molecular methods to investigate the changes in the genome expression pattern of various bacterial pathogens that occur during their interaction with their target host.

2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases: The unique features of various newly emerged bacterial pathogens are being studied by analyzing their genomes and comparing them with those of other bacterial strains.

3. Investigation of the life cycles of bacterial pathogens in their natural environments: Based on what is currently understood about various bacterial pathogens, we are seeking to characterize their life cycles in their natural habitats.

4. Development of new methods for the rapid identification of bacterial pathogens based on genomic information: To rapidly diagnose bacterial infections, a novel system for identifying bacterial pathogens by high-throughput DNA sequencing is being developed.

Major publications

  1. Okada R, Zhou X, Hiyoshi H, Matsuda S, Chen X, Akeda Y, Kashimoto T, Davis BM, Iida T, Waldor MK, Kodama T. The Vibrio parahaemolyticus effector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection. Cell Microbiol. 2014 Jun;16(6):938-47.
  2. Matsuda S, Okada N, Kodama T, Honda T, Iida T. A cytotoxic type III secretion effector of Vibrio parahaemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosomes. PLoS Pathog. 2012 Jul 19;8(7):e1002803.
  3. Hiyoshi H, Kodama T, Saito K, Gotoh K, Matsuda S, Akeda Y, Honda T, Iida T. VopV, an F-actin-binding type III secretion effector, is required for Vibrio parahaemolyticus-induced enterotoxicity. Cell Host Microbe. 2011 Oct 20;10(4):401-9.
  4. Monira S, Nakamura S, Gotoh K, Izutsu K, Watanabe H, Alam NH, Endtz HP, Cravioto A, Ali SI, Nakaya T, Horii T, Iida T, Alam M. Gut microbiota of healthy and malnourished children in Bangladesh. Front Microbiol. 2011 Nov 21;2:228.
  5. Gotoh K, Kodama T, Hiyoshi H, Izutsu K, Park KS, Dryselius R, Akeda Y, Honda T, Iida T. Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants. PLoS One. 2010 Oct 13;5(10):e13365.
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