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Osaka University
Research Institute for Microbial Diseases

Research Theme:
Elucidation of Mechanisms of Innate Immunity

Principal Research Scientist
Shizuo Akira
Profile:
M.D. Osaka University School of Medicine, 1977
Clinical Training and Physician (1977-1980).
Ph.D. Osaka University, Graduate School of Medicine, 1984.
Research Fellow, University of California, Berkeley (1985-1987).
Research Associate (1987-1995), Associate Professor, Institute for Molecular and Cellular Biology, Osaka University (1995).
Professor of Biochemistry, Hyogo College of Medicine (1996-1999).
Professor, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University (1999-present).
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Collaborators
Cevayir Coban (Postdoctral Fellow of COE)
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Publications
1. Akira, S., Takeda, K., Kaisho, T.: Toll-like receptors: critical proteins linking innate
and acquired immunity. Nat. Immunol. 2: 675-680, 2001.

2. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., and Akira, S. A Toll-like receptor recognizes bacterial DNA. Nature, 408, 740-745, 2000

3. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S. Small anti-viral compounds activate immune cells via the TLR7-MyD88-dependent signaling pathway. Nature Immunol. 3, 196-200, 2002.

4. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K., Akira, S. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature. 420:324-329, 2002.

5. Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K. and Akira, S. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science, 301:640-3, 2003.

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