Department of Molecular Microbiology

Staff:

Professor

Eiji Hara, Ph.D.

Associate Professor

Sugiko Watanabe, M.D., Ph.D.

Assistant Professor

Shimpei Kawamoto, Ph.D.

Specially Appointed Researcher

Masahiro Wakita, Ph.D.

Tatsuyuki Matsudaira, Ph.D.

Subjects:

1. Regulation of tumorigenesis by cellular senescence.
2. Understanding the roles and mechanisms of SASP.
3. Understanding the roles of cellular senescence in vivo.
4. Understanding the roles and mechanisms of gut microbiota in cancer.

Papers published in 2017

1. p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis.

   Atsushi Okuma, Aki Hanyu, Sugiko Watanabe and Eiji Hara

   Nat Commun, 8 (1), 2050, 2017.
2. Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.

   Masaki Takasugi, Ryo Okada, Akiko Takahashi, David Virya Chen, Sugiko Watanabe and Eiji Hara

   Nat Commun, 8, 15729, 2017.
3. Exosomes maintain cellular homeostasis by excreting harmful DNA from cells.

   Akiko Takahashi, Ryo Okada, Koji Nagao, Yuka Kawamata, Aki Hanyu, Shin Yoshimoto, Masaki Takasugi, Sugiko Watanabe, Masato T Kanemaki, Chikashi Obuse and Eiji Hara

   Nat Commun, 8, 15287, 2017.
4. Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.

   Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto, Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Masaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M Taketo, Tomohiro Aoki, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara and Naoko Ohtani

   Cancer Discov, 7 (5), 522-538, 2017.
5. Impact of senescence-associated secretory phenotype and its potential as a therapeutic target for senescence-associated diseases.

   Sugiko Watanabe, Shimpei Kawamoto, Naoko Ohtani and Eiji Hara

   Cancer Sci, 108 (4), 563-569, 2017.

Link

Department of Molecular Microbiology

Research Institute for Microbial Diseases, Osaka University