Department of Immunoparasitology

Staff:

Professor

Masahiro Yamamoto, Ph.D.

Associate Professor

Miwa Sasai, Ph.D.

Specially Appointed Assistant Professor

Hironori Bando, Ph.D.

Graduate Student

Naoya Sakaguchi

Research Student

Ariel Pradipta, M.D.

Subjects:

1. Negative regulation of interferon-g-induced cell-autonomous immunity to Toxoplasma by RabGDIα
2. Involvement of p62/Sqstm1 in interferon-g-dependent Toxoplasama antigen presentation
3. Essential role of GBPs in AIM2 inflammasome activation by Francisella

Papers published in 2015

1. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

   Etienne Meunier, Pierre Wallet, Roland F Dreier, Stéphanie Costanzo, Leonie Anton, Sebastian Rühl, Sébastien Dussurgey, Mathias S Dick, Anne Kistner, Mélanie Rigard, Daniel Degrandi, Klaus Pfeffer, Masahiro Yamamoto, Thomas Henry and Petr Broz

   Nat Immunol, 16 (5), 476-484, 2015.
2. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

   Si Ming Man, Rajendra Karki, R K Subbarao Malireddi, Geoffrey Neale, Peter Vogel, Masahiro Yamamoto, Mohamed Lamkanfi and Thirumala-Devi Kanneganti

   Nat Immunol, 16 (5), 467-475, 2015.
3. Guanylate Binding Proteins Enable Rapid Activation of Canonical and Noncanonical Inflammasomes in Chlamydia-Infected Macrophages.

   Ryan Finethy, Ine Jorgensen, Arun K Haldar, Marcel R de Zoete, Till Strowig, Richard A Flavell, Masahiro Yamamoto, Uma M Nagarajan, Edward A Miao and Jörn Coers

   Infect Immun, 83 (12), 4740-4749, 2015.
4. Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface.

   Pierre-Mehdi Hammoudi, Damien Jacot, Christina Mueller, Manlio Di Cristina, Sunil Kumar Dogga, Jean-Baptiste Marq, Julia Romano, Nicolò Tosetti, Juan Dubrot, Yalin Emre, Matteo Lunghi, Isabelle Coppens, Masahiro Yamamoto, Daniel Sojka, Paco Pino and Dominique Soldati-Favre

   PLoS Pathog, 11 (10), e1005211, 2015.
5. Toll-like receptor 9 trafficking and signaling for type I interferons requires PIKfyve activity.

   Kachiko Hayashi, Miwa Sasai and Akiko Iwasaki

   Int Immunol, 27 (9), 435-445, 2015.
6. mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.

   Daisuke Ito, Satoshi Nojima, Masayuki Nishide, Tatsusada Okuno, Hyota Takamatsu, Sujin Kang, Tetsuya Kimura, Yuji Yoshida, Keiko Morimoto, Yohei Maeda, Takashi Hosokawa, Toshihiko Toyofuku, Jun Ohshima, Daisuke Kamimura, Masahiro Yamamoto, Masaaki Murakami, Eiichi Morii, Hiromi Rakugi, Yoshitaka Isaka and Atsushi Kumanogoh

   J Immunol, 195 (3), 934-943, 2015.
7. p62 Plays a Specific Role in Interferon-γ-Induced Presentation of a Toxoplasma Vacuolar Antigen.

   Youngae Lee, Miwa Sasai, Ji Su Ma, Naoya Sakaguchi, Jun Ohshima, Hironori Bando, Tatsuya Saitoh, Shizuo Akira and Masahiro Yamamoto

   Cell Rep, 13 (2), 223-233, 2015.
8. RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

   Jun Ohshima, Miwa Sasai, Jianfa Liu, Kazuo Yamashita, Ji Su Ma, Youngae Lee, Hironori Bando, Jonathan C Howard, Shigeyuki Ebisu, Mikako Hayashi, Kiyoshi Takeda, Daron M Standley, Eva-Maria Frickel and Masahiro Yamamoto

   Proc Natl Acad Sci U S A, 112 (33), E4581-4590, 2015.

Link

Department of Immunoparasitology

Research Institute for Microbial Diseases, Osaka University