Department of Immunoregulation

Staff:

Professor(SUP)

Taroh Kinoshita, Ph.D.

Associate Professor

Yusuke Maeda, M.D., Ph.D.

Associate Professor(SUP)

Yoshiko Murakami, M.D., Ph.D.

Assistant Professor

Yuko Tashima, Ph.D.

Specially Appointed Assistant Professor

Noriyuki Kanzawa, Ph.D.

Specially Apointed Researcher(SUP)

Chandan Mandal, Ph.D.

Graduate Student

Gun Hee Lee

Tetsuya Hirata

Yicheng Wang

Research Student

Keiko Kinoshita

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. pH regulation and its biological significance in acidic organelles.

Papers published in 2015

1. Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol deficiencies.

   Biljana Ilkovski, Alistair T Pagnamenta, Gina L O'Grady, Taroh Kinoshita, Malcolm F Howard, Monkol Lek, Brett Thomas, Anne Turner, John Christodoulou, David Sillence, Samantha J L Knight, Niko Popitsch, David A Keays, Consuelo Anzilotti, Anne Goriely, Leigh B Waddell, Fabienne Brilot, Kathryn N North, Noriyuki Kanzawa, Daniel G Macarthur, Jenny C Taylor, Usha Kini, Yoshiko Murakami and Nigel F Clarke

   Hum Mol Genet, 24 (21), 6146-6159, 2015.
2. Genome-Wide Screening of Genes Required for Glycosylphosphatidylinositol Biosynthesis.

   Yao Rong, Shota Nakamura, Tetsuya Hirata, Daisuke Motooka, Yi-Shi Liu, Zeng-An He, Xiao-Dong Gao, Yusuke Maeda, Taroh Kinoshita and Morihisa Fujita

   PLoS One, 10 (9), e0138553, 2015.
3. Post-Golgi anterograde transport requires GARP-dependent endosome-to-TGN retrograde transport.

   Tetsuya Hirata, Morihisa Fujita, Shota Nakamura, Kazuyoshi Gotoh, Daisuke Motooka, Yoshiko Murakami, Yusuke Maeda and Taroh Kinoshita

   Mol Biol Cell, 26 (17), 3071-3084, 2015.
4. Cerebral visual impairment and intellectual disability caused by PGAP1 variants.

   Daniëlle G M Bosch, F Nienke Boonstra, Taroh Kinoshita, Shalini Jhangiani, Joep de Ligt, Frans P M Cremers, James R Lupski, Yoshiko Murakami and Bert B A de Vries

   Eur J Hum Genet, 23 (12), 1689-1693, 2015.
5. Mutations in PIGL in a patient with Mabry syndrome.

   Ikuma Fujiwara, Yoshiko Murakami, Tetsuya Niihori, Junko Kanno, Akiko Hakoda, Osamu Sakamoto, Nobuhiko Okamoto, Ryo Funayama, Takeshi Nagashima, Keiko Nakayama, Taroh Kinoshita, Shigeo Kure, Yoichi Matsubara and Yoko Aoki

   Am J Med Genet A, 167A (4), 777-785, 2015.
6. Structural changes of GPI anchor after its attachment to proteins: functional significance.

   Taroh Kinoshita

   Adv Exp Med Biol, 842, 17-25, 2015.

Link

Department of Immunoregulation

Research Institute for Microbial Diseases, Osaka University