Department of Oncogene Research

Staff:

Professor

Masato Okada, Ph.D.

Associate Professor

Shigeyuki Nada, Ph.D.

Chitose Oneyama, Ph.D.

Specially Appointed Researcher

Kentaro Kajiwara, Ph.D.

Graduate Student

Rei Matsuyama, M.Sc.

Yu komiya, M.Sc.

Yuichi Ninomiya,

Atsushi Kuwahara

Jun Nakayama

Mari Nada

Lee Le Shi

Keisuke Kitano

Kentaro Tanaka

Risa Ohno

Undergraduate Student

Akiko Nakayama

Choo Jun Jie

Yuki Kubo

Kim Junhyeong

Subjects:

1. Functions of the Src family tyrosine kinases (SFK).
2. Molecular mechanisms of SFK-mediated cell transformation.
3. Regulation of tumor growth via the endosomal compartments.

Papers published in 2014

1. c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions.

   Kentaro Kajiwara, Takayuki Yamada, Takeshi Bamba, Eiichiro Fukusaki, Fumio Imamoto, Masato Okada and Chitose Oneyama

   Biochem J, 458 (1), 81-93, 2014.
2. The mTOR pathway controls cell proliferation by regulating the FoxO3a transcription factor via SGK1 kinase.

   Shunsuke Mori, Shigeyuki Nada, Hironobu Kimura, Shoji Tajima, Yusuke Takahashi, Ayaka Kitamura, Chitose Oneyama and Masato Okada

   PLoS One, 9 (2), e88891, 2014.
3. p18/LAMTOR1: a late endosome/lysosome-specific anchor protein for the mTORC1/MAPK signaling pathway.

   Shigeyuki Nada, Shunsuke Mori, Yusuke Takahashi and Masato Okada

   Methods Enzymol, 535, 249-263, 2014.
4. Roles of Raft-Anchored Adaptor Cbp/PAG1 in Spatial Regulation of c-Src Kinase.

   Takashi Saitou, Kentaro Kajiwara, Chitose Oneyama, Takashi Suzuki and Masato Okada

   PLoS One, 9 (3), e93470, 2014.
5. Osh proteins regulate COPII-mediated vesicular transport of ceramide from the endoplasmic reticulum in budding yeast.

   Kentaro Kajiwara, Atsuko Ikeda, Auxiliadora Aguilera-Romero, Guillaume A Castillon, Satoshi Kagiwada, Kentaro Hanada, Howard Riezman, Manuel Muñiz and Kouichi Funato

   J Cell Sci, 127 (Pt 2), 376-387, 2014.

Link

Department of Oncogene Research

Research Institute for Microbial Diseases, Osaka University