Department of Immunoparasitology

Staff:

Professor

Masahiro Yamamoto., Ph.D.

Assistant Professor

Miwa Sasai., Ph.D.

Postdoctoral fellow

Lee Youngae., Ph.D.

Graduate Student

Ji Su Ma

Jun Oshima

Subjects:

1. Analysis of IFN-gamma-induced cell-autonomous immunity against Toxoplasm gondii
2. Mechanisms of Toxoplasma virulence by the dense granule proteins

Papers published in 2014

1. Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

   Danielle M Pilla, Jon A Hagar, Arun K Haldar, Ashley K Mason, Daniel Degrandi, Klaus Pfeffer, Robert K Ernst, Masahiro Yamamoto, Edward A Miao and Jörn Coers

   Proc Natl Acad Sci U S A, 111 (16), 6046-6051, 2014.
2. Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.

   Ji Su Ma, Miwa Sasai, Jun Ohshima, Youngae Lee, Hironori Bando, Kiyoshi Takeda and Masahiro Yamamoto

   J Exp Med, 211 (10), 2013-2032, 2014.
3. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

   Etienne Meunier, Mathias S Dick, Roland F Dreier, Nura Schürmann, Daniela Kenzelmann Broz, Søren Warming, Merone Roose-Girma, Dirk Bumann, Nobuhiko Kayagaki, Kiyoshi Takeda, Masahiro Yamamoto and Petr Broz

   Nature, 509 (7500), 366-370, 2014.
4. Innate immune response induced by baculovirus attenuates transgene expression in Mammalian cells.

   Chikako Ono, Akinori Ninomiya, Satomi Yamamoto, Takayuki Abe, Xiauyu Wen, Takasuke Fukuhara, Miwa Sasai, Masahiro Yamamoto, Tatsuya Saitoh, Takashi Satoh, Taro Kawai, Ken J Ishii, Shizuo Akira, Toru Okamoto and Yoshiharu Matsuura

   J Virol, 88 (4), 2157-2167, 2014.
5. The E2-like conjugation enzyme Atg3 promotes binding of IRG and Gbp proteins to Chlamydia- and Toxoplasma-containing vacuoles and host resistance.

   Arun K Haldar, Anthony S Piro, Danielle M Pilla, Masahiro Yamamoto and Jörn Coers

   PLoS One, 9 (1), e86684, 2014.
6. Role of Mouse and Human Autophagy Proteins in IFN-γ-Induced Cell-Autonomous Responses against Toxoplasma gondii.

   Jun Ohshima, Youngae Lee, Miwa Sasai, Tatsuya Saitoh, Ji Su Ma, Naganori Kamiyama, Yoshiharu Matsuura, Suh Pann-Ghill, Mikako Hayashi, Shigeyuki Ebisu, Kiyoshi Takeda, Shizuo Akira and Masahiro Yamamoto

   J Immunol, 192 (7), 3328-3335, 2014.

Link

Department of Immunoparasitology

Research Institute for Microbial Diseases, Osaka University