Laboratory of Genomic Research on Pathogenic Bacteria

Staff:

Specially Appointed Professor

Tetsuya Iida, Ph.D.

Specially Appointed Assistant Professor

Shigeaki Matsuda, Ph.D.

Specially Appointed Researcher

Chonchanok Theethakaew, Ph.D.

Graduate Student

Ryu Okada

Sarunporn Tandhavanant

Haruka Hayashi

Subjects:

1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression.
2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases.
3. Investigation of the life cycles of bacterial pathogens in their natural environments.
4. Development of new methods for the rapid identification of bacterial pathogens based on genome information.

Papers published in 2014

1. Complete nucleotide sequence of a plasmid containing the botulinum neurotoxin gene in Clostridium botulinum type B strain 111 isolated from an infant patient in Japan.

   Koji Hosomi, Yoshihiko Sakaguchi, Tomoko Kohda, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Kaoru Umeda, Tetsuya Iida, Shunji Kozaki and Masafumi Mukamoto

   Mol Genet Genomics, 289 (6), 1267-1274, 2014.
2. Performance comparison of second- and third-generation sequencers using a bacterial genome with two chromosomes.

   Mari Miyamoto, Daisuke Motooka, Kazuyoshi Gotoh, Takamasa Imai, Kazutoshi Yoshitake, Naohisa Goto, Tetsuya Iida, Teruo Yasunaga, Toshihiro Horii, Kazuharu Arakawa, Masahiro Kasahara and Shota Nakamura

   BMC Genomics, 15, 699, 2014.
3. Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae

   Masafumi Seki, Hisao Yoshida, Kazuyoshi Goto, Nobuyuki Hamada, Daisuke Motooka, Shota Nakamura, Norihisa Yamamoto, Shigeto Hamaguchi, Yukihiro Akeda, Hiroshi Watanabe, Tetsuya Iida and Kazunori Tomono

   Respiratory Medicine Case Reports, 12, 13-15, 2014.
4. Allergic bronchopulmonary mycosis due to co-infection with Aspergillus fumigatus and Schizophyllum commune

   Masafumi Seki, Hideaki Ohno, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Tetsuya Iida, Yoshitsugu Miyazaki and Kazunori Tomono

   ID Cases, 1 (1), 5-8, 2014.
5. Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice.

   Satoshi Hiyama, Hideki Iijima, Shinichiro Shinzaki, Takahiro Inoue, Eri Shiraishi, Shoichiro Kawai, Manabu Araki, Motohiko Kato, Yoshito Hayashi, Tsutomu Nishida, Hironobu Fujii, Akira Mukai, Naoko Shibata, Shintaro Sato, Hiroshi Kiyono, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Tetsuya Iida, Masahiko Tsujii and Tetsuo Takehara

   Inflamm Bowel Dis, 20 (5), 790-799, 2014.
6. BEC, a novel enterotoxin of Clostridium perfringens found in human clinical isolates from acute gastroenteritis outbreaks.

   Shinya Yonogi, Shigeaki Matsuda, Takao Kawai, Tomoko Yoda, Tetsuya Harada, Yuko Kumeda, Kazuyoshi Gotoh, Hirotaka Hiyoshi, Shota Nakamura, Toshio Kodama and Tetsuya Iida

   Infect Immun, 82 (6), 2390-2399, 2014.
7. Generation of colonic IgA-secreting cells in the caecal patch.

   Kazunori Masahata, Eiji Umemoto, Hisako Kayama, Manato Kotani, Shota Nakamura, Takashi Kurakawa, Junichi Kikuta, Kazuyoshi Gotoh, Daisuke Motooka, Shintaro Sato, Tomonori Higuchi, Yoshihiro Baba, Tomohiro Kurosaki, Makoto Kinoshita, Yosuke Shimada, Taishi Kimura, Ryu Okumura, Akira Takeda, Masaru Tajima, Osamu Yoshie, Masahiro Fukuzawa, Hiroshi Kiyono, Sidonia Fagarasan, Tetsuya Iida, Masaru Ishii and Kiyoshi Takeda

   Nat Commun, 5, 3704, 2014.
8. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota.

   Kei Arimatsu, Hitomi Yamada, Haruna Miyazawa, Takayoshi Minagawa, Mayuka Nakajima, Mark I Ryder, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Tetsuya Iida and Kazuhisa Yamazaki

   Sci Rep, 4, 4828, 2014.
9. Physiologic and metagenomic attributes of the rhodoliths forming the largest CaCO3 bed in the South Atlantic Ocean.

   Giselle S Cavalcanti, Gustavo B Gregoracci, Eidy O dos Santos, Cynthia B Silveira, Pedro M Meirelles, Leila Longo, Kazuyoshi Gotoh, Shota Nakamura, Tetsuya Iida, Tomoo Sawabe, Carlos E Rezende, Ronaldo B Francini-Filho, Rodrigo L Moura, Gilberto M Amado-Filho and Fabiano L Thompson

   ISME J, 8 (1), 52-62, 2014.
10. Comprehensive metagenomic approach for detecting causative microorganisms in culture-negative infective endocarditis.

    Atsuko Imai, Kazuyoshi Gotoh, Yoshihiro Asano, Noriaki Yamada, Daisuke Motooka, Masaki Fukushima, Machiko Kanzaki, Tomohito Ohtani, Yasushi Sakata, Hiroyuki Nishi, Koichi Toda, Yoshiki Sawa, Issei Komuro, Toshihiro Horii, Tetsuya Iida, Shota Nakamura and Seiji Takashima

    Int J Cardiol, 172 (2), e288-289, 2014.
11. The Vibrio parahaemolyticus effector VopC mediates Cdc42-dependent invasion of cultured cells but is not required for pathogenicity in an animal model of infection.

    Ryu Okada, Xiaohui Zhou, Hirotaka Hiyoshi, Shigeaki Matsuda, Xiang Chen, Yukihiro Akeda, Takashige Kashimoto, Brigid M Davis, Tetsuya Iida, Matthew K Waldor and Toshio Kodama

    Cell Microbiol, 16 (6), 938-947, 2014.

Link

Laboratory of Genomic Research on Pathogenic Bacteria

Research Institute for Microbial Diseases, Osaka University