Department of Viral Infections

Staff:

Professor

Tatsuo Shioda, Ph.D.

Associate Professor

Emi E. Nakayama, M.D., Ph.D.

Assistant Professor

Jun-ichi Sakuragi, Ph.D.

Specially Appointed Researcher

Sayuri Sakuragi, Ph.D.

Eri Takeda, Ph.D.

Kahoru Taya, Ph.D.

Research Student

Tahmina Sultana

Subjects:

1. Analysis of host genetic factors affecting disease courses of human immunodeficiency virus (HIV) infection.
2. Studies on chemokines and chemokine receptors.
3. Analysis of molecular mechanisms of HIV entry into target cells.
4. Analysis of molecular mechanisms of HIV virion formation.
5. Development of a novel vector system based on Sendai virus.

Papers published in 2013

1. Generation of rhesus macaque-tropic HIV-1 clones that are resistant to major anti-HIV-1 restriction factors.

   Masako Nomaguchi, Masaru Yokoyama, Ken Kono, Emi E Nakayama, Tatsuo Shioda, Naoya Doi, Sachi Fujiwara, Akatsuki Saito, Hirofumi Akari, Kei Miyakawa, Akihide Ryo, Hirotaka Ode, Yasumasa Iwatani, Tomoyuki Miura, Tatsuhiko Igarashi, Hironori Sato and Akio Adachi

   J Virol, 87 (21), 11447-11461, 2013.
2. Slower uncoating is associated with impaired replicative capability of simian-tropic HIV-1.

   Ken Kono, Eri Takeda, Hiromi Tsutsui, Ayumu Kuroishi, Amy E Hulme, Thomas J Hope, Emi E Nakayama and Tatsuo Shioda

   PLoS One, 8 (8), e72531, 2013.
3. A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection.

   Emi E Nakayama, Toshiaki Nakajima, Gurvinder Kaur, Jun-ich Mimaya, Hiroshi Terunuma, Narinder Mehra, Akinori Kimura and Tatsuo Shioda

   AIDS Res Hum Retroviruses, 29 (6), 919-924, 2013.
4. TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1.

   Akatsuki Saito, Masako Nomaguchi, Ken Kono, Yasumasa Iwatani, Masaru Yokoyama, Yasuhiro Yasutomi, Hironori Sato, Tatsuo Shioda, Wataru Sugiura, Tetsuro Matano, Akio Adachi, Emi E Nakayama and Hirofumi Akari

   J Gen Virol, 94 (Pt 6), 1318-1324, 2013.
5. Systemic biological analysis of the mutations in two distinct HIV-1mt genomes occurred during replication in macaque cells.

   Masako Nomaguchi, Naoya Doi, Sachi Fujiwara, Akatsuki Saito, Hirofumi Akari, Emi E Nakayama, Tatsuo Shioda, Masaru Yokoyama, Hironori Sato and Akio Adachi

   Microbes Infect, 15 (4), 319-328, 2013.
6. Efavirenz enhances HIV-1 gag processing at the plasma membrane through Gag-Pol dimerization.

   Sho Sudo, Hiyori Haraguchi, Yoko Hirai, Hiroyuki Gatanaga, Jun-ichi Sakuragi, Fumitaka Momose and Yuko Morikawa

   J Virol, 87 (6), 3348-3360, 2013.
7. Gag-CA Q110D mutation elicits TRIM5-independent enhancement of HIV-1mt replication in macaque cells.

   Masako Nomaguchi, Masaru Yokoyama, Ken Kono, Emi E Nakayama, Tatsuo Shioda, Akatsuki Saito, Hirofumi Akari, Yasuhiro Yasutomi, Tetsuro Matano, Hironori Sato and Akio Adachi

   Microbes Infect, 15 (1), 56-65, 2013.
8. Polymorphisms in Fas gene is associated with HIV-related lipoatrophy in Thai patients.

   Sirirat Likanonsakul, Tippawan Rattanatham, Siriluk Feangvad, Sumonmal Uttayamakul, Wisit Prasithsirikul, Somkid Srisopha, Ravee Nitiyanontakij, Pimrapat Tengtrakulcharoen, Maciej Tarkowski, Agostino Riva, Emi E Nakayama and Tatsuo Shioda

   AIDS Res Hum Retroviruses, 29 (1), 142-150, 2013.

Link

http://www.biken.osaka-u.ac.jp/