Department of Oncogene Research

Subjects:

1. Functions of the Src family tyrosine kinases (SFK).
2. Molecular mechanisms of SFK-mediated cell transformation.
3. Regulation of tumor growth via the endosomal compartments.

Papers published in 2012

1. MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.

   Hitomi Masuda, Kuniaki Nakamura, Nozomu Takata, Bunsho Itoh, Takashi Hirose, Hiroki Moribe, Eisuke Mekada and Masato Okada

   FEBS Lett, 586 (6), 740-746, 2012.
2. The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes.

   Yusuke Takahashi, Shigeyuki Nada, Shunsuke Mori, Taeko Soma-Nagae, Chitose Oneyama and Masato Okada

   Biochem Biophys Res Commun, 417 (4), 1151-1157, 2012.
3. Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP)-13 expression.

   Kaoru Yamagata, Xin Li, Shunkichi Ikegaki, Chitose Oneyama, Masato Okada, Michiru Nishita and Yasuhiro Minami

   J Biol Chem, 287 (2), 1588-1599, 2012.
4. A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF.

   Akihiro Watari, Yang Li, Shinji Higashiyama and Masuo Yutsudo

   Exp Cell Res, 318 (3), 187-195, 2012.
5. MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression.

   C Oneyama, E Morii, D Okuzaki, Y Takahashi, J Ikeda, N Wakabayashi, H Akamatsu, M Tsujimoto, T Nishida, K Aozasa and M Okada

   Oncogene, 31 (13), 1623-1635, 2012.

Link

http://www.biken.osaka-u.ac.jp/