Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. pH regulation and its biological significance in acidic organelles.

Papers published in 2012

1. Deregulated expression of HMGA2 is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuria.

   Yoshiko Murakami, Norimitsu Inoue, Tsutomu Shichishima, Rieko Ohta, Hideyoshi Noji, Yusuke Maeda, Jun-Ichi Nishimura, Yuzuru Kanakura and Taroh Kinoshita

   Br. J. Haematol., 156 (3), 383-387, 2012.
2. Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins.

   Hidekazu Murakami, Yetao Wang, Hidetoshi Hasuwa, Yusuke Maeda, Taroh Kinoshita and Yoshiko Murakami

   Biochem. Biophys. Res. Commun., 417 (4), 1235-1241, 2012.
3. Mechanism for release of alkaline phosphatase caused by glycosylphosphatidylinositol deficiency in patients with hyperphosphatasia-mental retardation syndrome.

   Yoshiko Murakami, Noriyuki Kanzawa, Kazunobu Saito, Peter M Krawitz, Stefan Mundlos, Peter N Robinson, Anastasios Karadimitris, Yusuke Maeda and Taroh Kinoshita

   J. Biol. Chem., 287 (9), 6318-6325, 2012.
4. Defective lipid remodeling of GPI anchors in peroxisomal disorders, Zellweger syndrome and rhizomelic chondrodysplasia punctata.

   Noriyuki Kanzawa, Nobuyuki Shimozawa, Ronald J A Wanders, Kazutaka Ikeda, Yoshiko Murakami, Hans R Waterham, Satoru Mukai, Morihisa Fujita, Yusuke Maeda, Ryo Taguchi, Yukio Fujiki and Taroh Kinoshita

   J. Lipid Res., 53 (4), 653-663, 2012.
5. GPI-anchor remodeling: Potential functions of GPI-anchors in intracellular trafficking and membrane dynamics.

   Morihisa Fujita and Taroh Kinoshita

   Biochim. Biophys. Acta, 1821 (8), 1050-1058, 2012.

Link

http://www.biken.osaka-u.ac.jp/