Laboratory of Genomic Research on Pathogenic Bacteria

Subjects:

1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression.
2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases.
3. Investigation of the life cycles of bacterial pathogens in their natural environments.
4. Development of new methods for the rapid identification of bacterial pathogens based on genome information.

Papers published in 2012

1. Immune response in diarrheal patients and asymptomatic carrier with CS6-producing enterotoxigenic Escherichia coli infection.

   Orapim Puiprom, Siriporn Chantaroj, Shigeaki Matsuda, Pathom Sawanpanyalert, Takeshi Honda, Tetsuya Iida and Tooru Taniguchi

   Southeast Asian J Trop Med Public Health, 43 (6), 1452-1460, 2012.
2. Functional cloning of Vibrio parahaemolyticus type III secretion system 1 in Escherichia coli K-12 strain as a molecular syringe.

   Yukihiro Akeda, Tomomi Kimura, Aiko Yamasaki, Toshio Kodama, Tetsuya Iida, Takeshi Honda and Kazunori Oishi

   Biochem Biophys Res Commun, 427 (2), 242-247, 2012.
3. Structure of the CFA/III major pilin subunit CofA from human enterotoxigenic Escherichia coli determined at 0.90 Å resolution by sulfur-SAD phasing.

   Shunsuke Fukakusa, Kazuki Kawahara, Shota Nakamura, Takaki Iwashita, Seiki Baba, Mitsuhiro Nishimura, Yuji Kobayashi, Takeshi Honda, Tetsuya Iida, Tooru Taniguchi and Tadayasu Ohkubo

   Acta Crystallogr D Biol Crystallogr, 68 (Pt 10), 1418-1429, 2012.
4. A Cytotoxic Type III Secretion Effector of Vibrio parahaemolyticus Targets Vacuolar H(+)-ATPase Subunit c and Ruptures Host Cell Lysosomes.

   Shigeaki Matsuda, Natsumi Okada, Toshio Kodama, Takeshi Honda and Tetsuya Iida

   PLoS Pathog., 8 (7), e1002803, 2012.
5. The hydrophilic translocator for Vibrio parahaemolyticus T3SS2 is also translocated.

   Xiaohui Zhou, Jennifer M Ritchie, Hirotaka Hiyoshi, Tetsuya Iida, Brigid M Davis, Matthew K Waldor and Toshio Kodama

   Infect. Immun., 80 (8), 2940-2947, 2012.
6. Inflammation and Disintegration of Intestinal Villi in an Experimental Model for Vibrio parahaemolyticus-Induced Diarrhea.

   Jennifer M Ritchie, Haopeng Rui, Xiaohui Zhou, Tetsuya Iida, Toshio Kodoma, Susuma Ito, Brigid M Davis, Roderick T Bronson and Matthew K Waldor

   PLoS Pathog, 8 (3), e1002593, 2012.
7. Frequency of D222G and Q223R Hemagglutinin Mutants of Pandemic (H1N1) 2009 Influenza Virus in Japan between 2009 and 2010.

   Mayo Yasugi, Shota Nakamura, Tomo Daidoji, Norihito Kawashita, Ririn Ramadhany, Cheng-Song Yang, Teruo Yasunaga, Tetsuya Iida, Toshihiro Horii, Kazuyoshi Ikuta, Kazuo Takahashi and Takaaki Nakaya

   PLoS One, 7 (2), e30946, 2012.

Link

http://www.biken.osaka-u.ac.jp/