Department of Viral Infections

Subjects:

1. Analysis of host genetic factors affecting disease courses of human immunodeficiency virus (HIV) infection.
2. Studies on chemokines and chemokine receptors.
3. Analysis of molecular mechanisms of HIV entry into target cells.
4. Analysis of molecular mechanisms of HIV virion formation.
5. Development of a novel vector system based on Sendai virus.

Published Papers

1. Morphogenesis of the Infectious HIV-1 Virion.

   Jun-Ichi Sakuragi

   Front Microbiol, 2, 242, 2011.
2. A Single Amino Acid of Human Immunodeficiency Virus Type 2 Capsid Protein Affects Conformation of Two External Loops and Viral Sensitivity to TRIM5α.

   Tadashi Miyamoto, Masaru Yokoyama, Ken Kono, Tatsuo Shioda, Hironori Sato and Emi E Nakayama

   PLoS One, 6 (7), e22779, 2011.
3. The relationship between HIV-1 genome RNA dimerization, virion maturation and infectivity.

   Masahisa Ohishi, Takashi Nakano, Sayuri Sakuragi, Tatsuo Shioda, Kouichi Sano and Jun-Ichi Sakuragi

   Nucleic Acids Res, 39 (8), 3404-3417, 2011.
4. Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications.

   Akatsuki Saito, Masako Nomaguchi, Sayuki Iijima, Ayumu Kuroishi, Tomoyuki Yoshida, Young-Jung Lee, Toshiyuki Hayakawa, Ken Kono, Emi E Nakayama, Tatsuo Shioda, Yasuhiro Yasutomi, Akio Adachi, Tetsuro Matano and Hirofumi Akari

   Microbes Infect, 13 (1), 58-64, 2011.

Link

http://www.biken.osaka-u.ac.jp/