Department of Immunoregulation

Subjects:

1. Biochemistry and molecular biology of biosynthesis pathway of GPI-anchored proteins.
2. Molecular pathogenesis of a GPI-anchor deficiencies, paroxysmal nocturnal hemoglobinuria and inherited GPI deficiency.
3. Roles of GPI in microorganisms.

Published Papers

1. Controlled expression of branch-forming mannosyltransferase is critical for mycobacterial lipoarabinomannan biosynthesis.

   Chubert B C Sena, Takeshi Fukuda, Kana Miyanagi, Sohkichi Matsumoto, Kazuo Kobayashi, Yoshiko Murakami, Yusuke Maeda, Taroh Kinoshita and Yasu S Morita

   J Biol Chem, 285 (18), 13326-13336, 2010.
2. Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation.

   Yuri Nakano, Morihisa Fujita, Kazutoyo Ogino, Louis Saint-Amant, Taroh Kinoshita, Yoichi Oda and Hiromi Hirata

   Development, 137 (10), 1689-1698, 2010.
3. Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria.

   Yasu S Morita, Yoshiki Yamaryo-Botte, Kana Miyanagi, Judy M Callaghan, John H Patterson, Paul K Crellin, Ross L Coppel, Helen Billman-Jacobe, Taroh Kinoshita and Malcolm J McConville

   J Biol Chem, 285 (22), 16643-16650, 2010.
4. Identity-by-descent filtering of exome sequence data identifies PIGV mutations in hyperphosphatasia mental retardation syndrome.

   Peter M Krawitz, Michal R Schweiger, Christian Rödelsperger, Carlo Marcelis, Uwe Kölsch, Christian Meisel, Friederike Stephani, Taroh Kinoshita, Yoshiko Murakami, Sebastian Bauer, Melanie Isau, Axel Fischer, Andreas Dahl, Martin Kerick, Jochen Hecht, Sebastian Köhler, Marten Jäger, Johannes Grünhagen, Birgit Jonske de Condor, Sandra Doelken, Han G Brunner, Peter Meinecke, Eberhard Passarge, Miles D Thompson, David E Cole, Denise Horn, Tony Roscioli, Stefan Mundlos and Peter N Robinson

   Nat Genet, 42 (10), 827-829, 2010.
5. The acidic environment of the Golgi is critical for glycosylation and transport.

   Yusuke Maeda and Taroh Kinoshita

   Methods Enzymol, 480, 495-510, 2010.
6. GPI-anchor: update for biosynthesis and remodeling.

   Yusuke Maeda, Morihisa Fujita and Taroh Kinoshita

   Trends Glycosci Glycotechnol, 22, 182-192, 2010.

Link

http://www.biken.osaka-u.ac.jp/