Department of Immunochemistry

Subjects:

1. Role of paired receptors on host defense.
2. Mechanism of virus entry into cells.
3. Analysis of molecules involved in host-pathogen interaction.

Published Papers

1. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1.

   Jun Arii, Hideo Goto, Tadahiro Suenaga, Masaaki Oyama, Hiroko Kozuka-Hata, Takahiko Imai, Atsuko Minowa, Hiroomi Akashi, Hisashi Arase, Yoshihiro Kawaoka and Yasushi Kawaguchi

   Nature, 467 (7317), 859-862, 2010.
2. A Single-Amino-Acid Substitution in Herpes Simplex Virus 1 Envelope Glycoprotein B at a Site Required for Binding to the Paired Immunoglobulin-Like Type 2 Receptor α (PILRα) Abrogates PILRα-Dependent Viral Entry and Reduces Pathogenesis.

   Jun Arii, Jing Wang, Tomomi Morimoto, Tadahiro Suenaga, Hiroomi Akashi, Hisashi Arase and Yasushi Kawaguchi

   J Virol, 84 (20), 10773-10783, 2010.
3. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses.

   Tadahiro Suenaga, Takeshi Satoh, Pranee Somboonthum, Yasushi Kawaguchi, Yasuko Mori and Hisashi Arase

   Proc Natl Acad Sci U S A, 107 (2), 866-871, 2010.

Link

http://www.biken.osaka-u.ac.jp/