Laboratory of Genomics Research on Pathogenic Bacteria

Subjects:

1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression.
2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases.
3. Investigation of the life cycles of bacterial pathogens in their natural environments.
4. Development of new methods for the rapid identification of bacterial pathogens based on genome information.

Published Papers

1. Two regulators of Vibrio parahaemolyticus play important roles in enterotoxicity by controlling the expression of genes in the Vp-PAI region.

   Toshio Kodama, Kazuyoshi Gotoh, Hirotaka Hiyoshi, Mikiharu Morita, Kaori Izutsu, Yukihiro Akeda, Kwon-Sam Park, Vlademir V Cantarelli, Rikard Dryselius, Tetsuya Iida and Takeshi Honda

   PLoS One, 5 (1), e8678, 2010.
2. Association of Vibrio parahaemolyticus thermostable direct hemolysin with lipid rafts is essential for cytotoxicity but not hemolytic activity.

   Shigeaki Matsuda, Toshio Kodama, Natsumi Okada, Kanna Okayama, Takeshi Honda and Tetsuya Iida

   Infect Immun, 78 (2), 603-610, 2010.
3. Contribution of Vibrio parahaemolyticus virulence factors to cytotoxicity, enterotoxicity and mice lethality.

   Hirotaka Hiyoshi, Toshio Kodama, Tetsuya Iida and Takeshi Honda

   Infect Immun, 78 (4), 1772-1780, 2010.
4. Aeromonas hydrophila PepO outer membrane endopeptidase activates human big endothelin-3 in vitro and induces skin ulcer in goldfish (Carassius auratus).

   Said Kamal Abolghait, Yukihiro Akeda, Toshio Kodama, Vlademir V Cantarelli, Tetsuya Iida and Takeshi Honda

   Vet Microbiol, 145 (1-2), 113-121, 2010.
5. Transcription of Vibrio parahaemolyticus T3SS1 genes is regulated by a dual regulation system consisting of the ExsACDE regulatory cascade and H-NS.

   Toshio Kodama, Chihiro Yamazaki, Kwon-Sam Park, Yukihiro Akeda, Tetsuya Iida and Takeshi Honda

   FEMS Microbiol Lett, 311 (1), 10-17, 2010.
6. Bile acid-induced virulence gene expression of Vibrio parahaemolyticus reveals a novel therapeutic potential for bile acid sequestrants.

   Kazuyoshi Gotoh, Toshio Kodama, Hirotaka Hiyoshi, Kaori Izutsu, Kwon-Sam Park, Rikard Dryselius, Yukihiro Akeda, Takeshi Honda and Tetsuya Iida

   PLoS One, 5 (10), e13365, 2010.
7. Presence of genes for type III secretion system 2 in Vibrio mimicus strains.

   Natsumi Okada, Shigeaki Matsuda, Junko Matsuyama, Kwon-Sam Park, Calvin de los Reyes, Kazuhiro Kogure, Takeshi Honda and Tetsuya Iida

   BMC Microbiol, 10, 302, 2010.

Link

http://www.biken.osaka-u.ac.jp/