Department of Virology

Subjects:

1. Pathogenesis of human immunodeficiency virus type 1.
2. Epidemiological, virological and molecular-biological characterization of Borna disease virus, influenza vrus, and dengue virus.
3. Mechanism of prion-induced pathogenesis in model systems.

Published Papers

1. Autogenous translational regulation of the borna disease virus negative control factor x from polycistronic mRNA using host RNA helicases.

   Yohei Watanabe, Naohiro Ohtaki, Yohei Hayashi, Kazuyoshi Ikuta and Keizo Tomonaga

   PLoS Pathog, 5 (11), e1000654, 2009.
2. Amantadine- and oseltamivir-resistant variants of influenza A viruses in Thailand.

   Gui-Rong Bai, Malinee Chittaganpitch, Yuta Kanai, Yong-Gang Li, Wattana Auwanit, Kazuyoshi Ikuta and Pathom Sawanpanyalert

   Biochem Biophys Res Commun, 390 (3), 897-901, 2009.
3. Impact of amino acid variations in Gag and protease of HIV type 1 CRF01_AE strains on drug susceptibility of virus to protease inhibitors.

   Piyamat Jinnopat, Panasda Isarangkura-na-ayuthaya, Piraporn Utachee, Yukiko Kitagawa, U Chandimal de Silva, Uamporn Siripanyaphinyo, Yoko Kameoka, Kenzo Tokunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit and Masanori Kameoka

   J Acquir Immune Defic Syndr, 52 (3), 320-328, 2009.
4. Short communication: RNA interference directed against Axin1 upregulates human immunodeficiency virus type 1 gene expression by activating the Wnt signaling pathway in HeLa-derived J111 cells.

   Masanori Kameoka, Yoko Kameoka, Piraporn Utachee, Takeshi Kurosu, Pathom Sawanpanyalert, Kazuyoshi Ikuta and Wattana Auwanit

   AIDS Res Hum Retroviruses, 25 (10), 1005-1011, 2009.
5. Molecular chaperone BiP interacts with Borna disease virus glycoprotein at cell surface.

   Tomoyuki Honda, Masayuki Horie, Takuji Daito, Kazuyoshi Ikuta and Keizo Tomonaga

   J Virol, 83 (23), 12622-12625, 2009.
6. Non-invasive prediction of hematocrit levels by portable visible and near-infrared spectrophotometer.

   Akikazu Sakudo, Yukiko Hakariya Kato, Hirohiko Kuratsune and Kazuyoshi Ikuta

   Clin Chim Acta, 408 (1-2), 123-127, 2009.
7. Broad neutralizing human monoclonal antibodies against influenza virus from vaccinated healthy donors.

   Ritsuko Kubota-Koketsu, Hiroyuki Mizuta, Masatoshi Oshita, Shoji Ideno, Mikihiro Yunoki, Motoki Kuhara, Naomasa Yamamoto, Yoshinobu Okuno and Kazuyoshi Ikuta

   Biochem Biophys Res Commun, 387 (1), 180-185, 2009.
8. Use of anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads for capture of respiratory syncytial virus.

   Akikazu Sakudo, Koichi Baba, Megumi Tsukamoto and Kazuyoshi Ikuta

   Bioorg Med Chem Lett, 19 (15), 4488-4491, 2009.
9. Detection of drug resistance-associated and background mutations in human immunodeficiency virus type 1 CRF01_AE protease and reverse transcriptase derived from drug treatment-naive patients residing in central Thailand.

   Wattana Auwanit, Panasda Isarangkura-Na-Ayuthaya, Dao Kasornpikul, Kazuyoshi Ikuta, Pathom Sawanpanyalert and Masanori Kameoka

   AIDS Res Hum Retroviruses, 25 (6), 625-631, 2009.
10. Heat shock cognate protein 70 controls Borna disease virus replication via interaction with the viral non-structural protein X.

    Yohei Hayashi, Masayuki Horie, Takuji Daito, Tomoyuki Honda, Kazuyoshi Ikuta and Keizo Tomonaga

    Microbes Infect, 11 (3), 394-402, 2009.
11. Visible and near-infrared spectral changes in the thumb of patients with chronic fatigue syndrome.

    Akikazu Sakudo, Yukiko Hakariya Kato, Seiki Tajima, Hirohiko Kuratsune and Kazuyoshi Ikuta

    Clin Chim Acta, 403 (1-2), 163-166, 2009.
12. Full-length sequence of genotype 3 hepatitis E virus derived from a pig in Thailand.

    Uamporn Siripanyaphinyo, Dusit Laohasinnarong, Juthamas Siripanee, Kampon Kaeoket, Masanori Kameoka, Kazuyoshi Ikuta and Pathom Sawanpanyalert

    J Med Virol, 81 (4), 657-664, 2009.
13. No apparent difference in the prevalence of parvovirus B19 infection between chronic fatigue syndrome patients and healthy controls in Japan.

    Yukiko Hakariya Kato, Masanobu Yamate, Muneo Tsujikawa, Hiromi Nishigaki, Yukie Tanaka, Mikihiro Yunoki, Hirohiko Kuratsune, Yasuyoshi Watanabe and Kazuyoshi Ikuta

    J Clin Virol, 44 (3), 246-247, 2009.
14. Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach.

    Shota Nakamura, Cheng-Song Yang, Naomi Sakon, Mayo Ueda, Takahiro Tougan, Akifumi Yamashita, Naohisa Goto, Kazuo Takahashi, Teruo Yasunaga, Kazuyoshi Ikuta, Tetsuya Mizutani, Yoshiko Okamoto, Michihira Tagami, Ryoji Morita, Norihiro Maeda, Jun Kawai, Yoshihide Hayashizaki, Yoshiyuki Nagai, Toshihiro Horii, Tetsuya Iida and Takaaki Nakaya

    PLoS ONE, 4 (1), e4219, 2009.
15. Secondary structural changes of proteins in fingernails of chronic fatigue syndrome patients from Fourier-transform infrared spectra.

    Akikazu Sakudo, Hirohiko Kuratsune, Yukiko Hakariya Kato and Kazuyoshi Ikuta

    Clin Chim Acta, 402 (1-2), 75-78, 2009.
16. Prion protein functions and dysfunction in prion diseases.

    Akikazu Sakudo and Kazuyoshi Ikuta

    Curr Med Chem, 16 (3), 380-389, 2009.
17. Phenotypic studies on recombinant human immunodeficiency virus type 1 (HIV-1) containing CRF01_AE env gene derived from HIV-1-infected patient, residing in central Thailand.

    Piraporn Utachee, Piyamat Jinnopat, Panasda Isarangkura-Na-Ayuthaya, U Chandimal de Silva, Shota Nakamura, Uamporn Siripanyaphinyo, Nuanjun Wichukchinda, Kenzo Tokunaga, Teruo Yasunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit and Masanori Kameoka

    Microbes Infect, 11 (3), 334-343, 2009.
18. Genotypic characterization of CRF01_AE env genes derived from human immunodeficiency virus type 1-infected patients residing in central Thailand.

    Piraporn Utachee, Piyamat Jinnopat, Panasda Isarangkura-Na-Ayuthaya, Udayanga Chandimal de Silva, Shota Nakamura, Uamporn Siripanyaphinyo, Nuanjun Wichukchinda, Kenzo Tokunaga, Teruo Yasunaga, Pathom Sawanpanyalert, Kazuyoshi Ikuta, Wattana Auwanit and Masanori Kameoka

    AIDS Res Hum Retroviruses, 25 (2), 229-236, 2009.
19. Portable visible and near-infrared spectrophotometer for triglyceride measurements.

    Takanori Kobayashi, Yukiko Hakariya Kato, Megumi Tsukamoto, Kazuyoshi Ikuta and Akikazu Sakudo

    Int J Mol Med, 23 (1), 75-79, 2009.
20. Anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus.

    Akikazu Sakudo, Koichi Baba, Megumi Tsukamoto, Atsuko Sugimoto, Takashi Okada, Takanori Kobayashi, Norihito Kawashita, Tatsuya Takagi and Kazuyoshi Ikuta

    Bioorg Med Chem, 17 (2), 752-757, 2009.
21. Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody.

    Anariwa Du, Tomo Daidoji, Takaaki Koma, Madiha S Ibrahim, Shota Nakamura, U Chandimal de Silva, Mayo Ueda, Cheng-Song Yang, Teruo Yasunaga, Kazuyoshi Ikuta and Takaaki Nakaya

    Biochem Biophys Res Commun, 378 (2), 197-202, 2009.
22. The effects of trichostatin A on the oncolytic ability of herpes simplex virus for oral squamous cell carcinoma cells.

    T Katsura, S Iwai, Y Ota, H Shimizu, K Ikuta and Y Yura

    Cancer Gene Ther, 16 (3), 237-245, 2009.
23. Sequence variation in hapatitis E virus genotypes 3 nad 4 from swine fecal samples in Japan.

    Sompong Sapsutthipas, Takeru Urayama, Masanobu Yamate, Muneo Tsujikawa, Hiromi Nishigaki, Katsuro Hagiwara, Mikihiro Yunoki, Hiroshi Yasue, Kunio Sato and Kazuhiro Ikuta

    Open Vet Sci J, 3, 68-75, 2009.

Link

http://www.biken.osaka-u.ac.jp/