Department of Viral Infections

Subjects:

1. Analysis of host genetic factors affecting disease courses of human immunodeficiency virus (HIV) infection.
2. Studies on chemokines and chemokine receptors.
3. Analysis of molecular mechanisms of HIV entry into target cells.
4. Analysis of molecular mechanisms of HIV virion formation.
5. Development of a novel vector system based on Sendai virus.

Published Papers

1. HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients.

   Sirirat Likanonsakul, Tippawan Rattanatham, Siriluk Feangvad, Sumonmal Uttayamakul, Wisit Prasithsirikul, Preecha Tunthanathip, Emi E Nakayama and Tatsuo Shioda

   AIDS Res Ther, 6, 22, 2009.
2. Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection.

   Toshiaki Nakajima, Emi E Nakayama, Gurvinder Kaur, Hiroshi Terunuma, Jun-ich Mimaya, Hitoshi Ohtani, Narinder Mehra, Tatsuo Shioda and Akinori Kimura

   AIDS, 23 (16), 2091-2100, 2009.
3. Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves replication in cynomolgus monkey cells.

   Ayumu Kuroishi, Akatsuki Saito, Yasuhiro Shingai, Tatsuo Shioda, Masako Nomaguchi, Akio Adachi, Hirofumi Akari and Emi E Nakayama

   Retrovirology, 6, 70, 2009.
4. Impact of a single amino acid in the variable region 2 of the Old World monkey TRIM5alpha SPRY (B30.2) domain on anti-human immunodeficiency virus type 2 activity.

   Ken Kono, Katarzyna Bozek, Francisco S Domingues, Tatsuo Shioda and Emi E Nakayama

   Virology, 388 (1), 160-168, 2009.

Link

http://www.biken.osaka-u.ac.jp/