Department of Oncogene Research

Subjects:

1. Functions of the Src family tyrosine kinases (SFK).
2. Molecular mechanisms of SFK-mediated cell transformation.
3. Regulation of tumor growth via the endosomal compartments.

Published Papers

1. Downregulation of drs tumor suppressor gene in highly malignant human pulmonary neuroendocrine tumors.

   Misuzu Shimakage, Ken Kodama, Kunimitsu Kawahara, Chul Jang Kim, Yoshihiko Ikeda, Masuo Yutsudo and Hirokazu Inoue

   Oncol Rep, 21 (6), 1367-1372, 2009.
2. Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain.

   Chitose Oneyama, Takuya Iino, Kazunobu Saito, Kei Suzuki, Akira Ogawa and Masato Okada

   Mol Cell Biol, 29 (24), 6462-6472, 2009.
3. A versatile nonviral vector system for tetracycline-dependent one-step conditional induction of transgene expression.

   K Inoue, T Sone, C Oneyama, F Nishiumi, H Kishine, Y Sasaki, T Andoh, M Okada, J D Chesnut and F Imamoto

   Gene Ther, 16 (12), 1383-1394, 2009.
4. Autonomous regulation of osteosarcoma cell invasiveness by Wnt5a/Ror2 signaling.

   M Enomoto, S Hayakawa, S Itsukushima, D Y Ren, M Matsuo, K Tamada, C Oneyama, M Okada, T Takumi, M Nishita and Y Minami

   Oncogene, 28 (36), 3197-3208, 2009.
5. [Lipid rafts controls the oncogenic potential of c-Src]

   Chitose Oneyama and Masato Okada

   Tanpakushitsu Kakusan Koso, 54 (3), 201-211, 2009.
6. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

   Shigeyki Nada, Akihiro Hondo, Atsuko Kasai, Masato Koike, Kazunobu Saito, Yasuo Uchiyama and Masato Okada

   EMBO J, 28 (5), 477-489, 2009.
7. Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.

   Nozomu Takata, Bunsho Itoh, Kazuyo Misaki, Takashi Hirose, Shigenobu Yonemura and Masato Okada

   Genes Cells, 14 (3), 381-393, 2009.

Link

http://www.biken.osaka-u.ac.jp/