Laboratory of Malariology

Subjects:

1. Demographic history of malaria parasites.
2. The evolution of antigen polymorphism in malaria parasites.
3. Co-evolution of malaria parasites and hosts.
4. The evolution of the mitochondrial genome of Apicomplexa.
5. Comparative genomics of Plasmodium vivax and related simian parasites.
6. Simulation of malaria drug resistance using mutator parasites.

Published Papers

1. Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees.

   Toshiyuki Hayakawa, Nobuko Arisue, Toshifumi Udono, Hirohisa Hirai, Jetsumon Sattabongkot, Tomoko Toyama, Takafumi Tsuboi, Toshihiro Horii and Kazuyuki Tanabe

   PLoS One, 4 (10), e7412, 2009.
2. Evidence for the transmission of Plasmodium vivax in the Republic of the Congo, West Central Africa.

   Richard Culleton, Mathieu Ndounga, Fadile Yildiz Zeyrek, Cevayir Coban, Prisca Nadine Casimiro, Satoru Takeo, Takafumi Tsuboi, Anjali Yadava, Richard Carter and Kazuyuki Tanabe

   J Infect Dis, 200 (9), 1465-1469, 2009.
3. Cross-reactivity in rapid diagnostic tests between human malaria and zoonotic simian malaria parasite Plasmodium knowlesi infections.

   Satoru Kawai, Makoto Hirai, Kosuke Haruki, Kazuyuki Tanabe and Yuichi Chigusa

   Parasitol Int, 58 (3), 300-302, 2009.
4. Genetic diversity and population structure of Plasmodium falciparum in the Philippines.

   Moritoshi Iwagami, Pilarita T Rivera, Elena A Villacorte, Aleyla D Escueta, Toshimitsu Hatabu, Shin-ichiro Kawazu, Toshiyuki Hayakawa, Kazuyuki Tanabe and Shigeyuki Kano

   Malar J, 8, 96, 2009.
5. Spread and evolution of Plasmodium falciparum drug resistance.

   Toshihiro Mita, Kazuyuki Tanabe and Kiyoshi Kita

   Parasitol Int, 58 (3), 201-209, 2009.
6. Strain-specific immunity may drive adaptive polymorphism in the merozoite surface protein 1 of the rodent malaria parasite Plasmodium chabaudi.

   Sandra Cheesman, Kazuyuki Tanabe, Hiromi Sawai, Elaine O'Mahony and Richard Carter

   Infect Genet Evol, 9 (2), 248-255, 2009.
7. Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa.

   Toshihiro Mita, Kazuyuki Tanabe, Nobuyuki Takahashi, Richard Culleton, Mathieu Ndounga, Mawuli Dzodzomenyo, Willis S Akhwale, Akira Kaneko and Takatoshi Kobayakawa

   J Antimicrob Chemother, 63 (2), 252-255, 2009.
8. Expression levels of Protocadherin-alpha transcripts are decreased by nonsense-mediated mRNA decay with frameshift mutations and by high DNA methylation in their promoter regions.

   Ryosuke Kaneko, Masahumi Kawaguchi, Tomoko Toyama, Yusuke Taguchi and Takeshi Yagi

   Gene, 430 (1-2), 86-94, 2009.
9. Seasonal attraction of the rice bug, Leptocorisa chinensis Dallas (Heteroptera: Alydidae), to synthetic attractants.

   T Watanabe, H Takeuchi, M Ishizaki, T Yasuda, S Tachibana, R Sasaki, K Nagano, Y Okutani-Akamatsu and N Matsuki

   Appl Entomol Zool, 44 (1), 155-164, 2009.

Link

http://www.biken.osaka-u.ac.jp/