Laboratory of Genomic Research on Pathogenic Bacteria

Subjects:

1. Characterization of the mechanism(s) used by bacterial pathogens to infect host organisms by identifying infection-related changes in pathogen genome expression.
2. Analysis of the mechanism(s) that lead to the emergence of new infectious diseases.
3. Investigation of the life cycles of bacterial pathogens in their natural environments.
4. Development of new methods for the rapid identification of bacterial pathogens based on genome information.

Published Papers

1. Identification and characterization of a novel type III secretion system in trh-positive Vibrio parahaemolyticus strain TH3996 reveal genetic lineage and diversity of pathogenic machinery beyond the species level.

   Natsumi Okada, Tetsuya Iida, Kwon-Sam Park, Naohisa Goto, Teruo Yasunaga, Hirotaka Hiyoshi, Shigeaki Matsuda, Toshio Kodama and Takeshi Honda

   Infect Immun, 77 (2), 904-913, 2009.
2. Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach.

   Shota Nakamura, Cheng-Song Yang, Naomi Sakon, Mayo Ueda, Takahiro Tougan, Akifumi Yamashita, Naohisa Goto, Kazuo Takahashi, Teruo Yasunaga, Kazuyoshi Ikuta, Tetsuya Mizutani, Yoshiko Okamoto, Michihira Tagami, Ryoji Morita, Norihiro Maeda, Jun Kawai, Yoshihide Hayashizaki, Yoshiyuki Nagai, Toshihiro Horii, Tetsuya Iida and Takaaki Nakaya

   PLoS ONE, 4 (1), e4219, 2009.
3. Identification and characterization of a type III secretion-associated chaperone in the type III secretion system 1 of Vibrio parahaemolyticus.

   Yukihiro Akeda, Kanna Okayama, Tomomi Kimura, Rikard Dryselius, Toshio Kodama, Kazunori Oishi, Tetsuya Iida and Takeshi Honda

   FEMS Microbiol Lett, 296 (1), 18-25, 2009.
4. Genomic taxonomy of Vibrios.

   Cristiane C Thompson, Ana Carolina P Vicente, Rangel C Souza, Ana Tereza R Vasconcelos, Tammi Vesth, Nelson Alves, David W Ussery, Tetsuya Iida and Fabiano L Thompson

   BMC Evol Biol, 9, 258, 2009.
5. Temperature-Dependency Urease Activity in Vibrio parahaemolyticus is Related to Transcriptional Activator UreR.

   Kwon-Sam Park, Soo-Jae Lee, Yong-Hyun Chung, Tetsuya Iida and Takeshi Honda

   J Microbiol Biotechnol, 19 (11), 1456-1463, 2009.

Link

http://www.biken.osaka-u.ac.jp/