Department of Bacterial Infections

Subjects:

1. Analysis of the bacterial colonization factors and their host receptors.
2. Molecular analysis of the protein toxins produced by various enteropathogen.
3. Analysis of the structure and function of the type III secretion system and the pathogenic mechanism of its effector.
4. Genome analysis of bacterial pathogens to understand pathogenic mechanisms.

Published Papers

1. Temperature-Dependency Urease Activity in Vibrio parahaemolyticus is Related to Transcriptional Activator UreR.

   Kwon-Sam Park, Soo-Jae Lee, Yong-Hyun Chung, Tetsuya Iida and Takeshi Honda

   J Microbiol Biotechnol, 19 (11), 1456-1463, 2009.
2. Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli.

   Yoshitoshi Ogura, Tadasuke Ooka, Atsushi Iguchi, Hidehiro Toh, Md Asadulghani, Kenshiro Oshima, Toshio Kodama, Hiroyuki Abe, Keisuke Nakayama, Ken Kurokawa, Toru Tobe, Masahira Hattori and Tetsuya Hayashi

   Proc Natl Acad Sci U S A, 106 (42), 17939-17944, 2009.
3. Functional analysis of type III secretion system 2 of Vibrio parahaemolyticus.

   Toshio Kodama

   Nippon Saikingaku Zasshi, 64 (2), 303-309, 2009.
4. Identification and characterization of a type III secretion-associated chaperone in the type III secretion system 1 of Vibrio parahaemolyticus.

   Yukihiro Akeda, Kanna Okayama, Tomomi Kimura, Rikard Dryselius, Toshio Kodama, Kazunori Oishi, Tetsuya Iida and Takeshi Honda

   FEMS Microbiol Lett, 296 (1), 18-25, 2009.
5. Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157:H7.

   Hidetada Hirakawa, Toshio Kodama, Asuka Takumi-Kobayashi, Takeshi Honda and Akihito Yamaguchi

   Microbiology, 155 (Pt 2), 541-550, 2009.
6. Identification and characterization of a novel type III secretion system in trh-positive Vibrio parahaemolyticus strain TH3996 reveal genetic lineage and diversity of pathogenic machinery beyond the species level.

   Natsumi Okada, Tetsuya Iida, Kwon-Sam Park, Naohisa Goto, Teruo Yasunaga, Hirotaka Hiyoshi, Shigeaki Matsuda, Toshio Kodama and Takeshi Honda

   Infect Immun, 77 (2), 904-913, 2009.

Link

http://www.biken.osaka-u.ac.jp/